Week 4 of the college football season features a matinee showdown as No. 22 Auburn heads to Norman to face No. 11 Oklahoma under the lights.
It’s the marquee matchup of the week, and our Auburn vs. Oklahoma predictions deliver the top insights you need to make smart college football picks for Saturday, September 20.
Auburn vs Oklahoma Week 4 predictions
- Oklahoma -6.5 (-110 at FanDuel)
- Over 46.5 (-110 at FanDuel)
- Jackson Arnold Over 174.5 passing yards (-114 at FanDuel)
- John Mateer anytime TD (-140 at FanDuel)
Auburn vs Oklahoma best bets
Oklahoma -6.5 (-110 at FanDuel)
One of these teams is 2-0 against the spread against FBS foes this season, and the other is 1-2.
Some deference should be given to Auburn for that dismal record, it still won each game by multiple possessions, but falling 9.5 points short of the 25.5-point spread against South Alabama is not exactly a close call, particularly since a field goal helped that cause with only 75 seconds remaining.
/ Over 46.5 (-110 at FanDuel)
We got spoiled. We, as college football fans, forgot how chaotic quarterback play can be, particularly behind offensive lines still trying to find chemistry.
The universal pandemic eligibility waiver created an era of greater experience than ever before in college football, and enjoying veteran quarterbacks behind established offensive lines became borderline typical.
It is not any longer.
Unless, perhaps, you are Auburn and Oklahoma. The right side of the Tigers’ offensive line, in particular, may as well already be ready for the NFL. And the Sooners have regained the push that helped define much of their last 25 years.
Courtesy of the transfer portal, both Auburn and Oklahoma employ veteran quarterbacks, the Tigers in fact trotting out the Sooners’ former quarterback in Jackson Arnold.
Both Arnold and his counterpart, John Mateer, are more than capable of adding an extra hat to the rushing attack, furthering these offenses’ dynamic options.
Simply put, no matchup with offensive lines like these and quarterbacks like these should feature a total below 49.
Stop taking quality line play and impressive quarterback performances as the standard. They are not. And offenses that can reliably trust them should be trusted to score points, particularly if they need to keep up with each other.
Auburn vs Oklahoma TD pick
John Mateer anytime TD (-140 at FanDuel)
This might not immediately scream value, but when fair odds should be around -200, it becomes my favorite bet on the board.
John Mateer’s return to Oklahoma has been a storybook one—he’s delivered big moments all season and even entered the Heisman conversation. I expect him to be heavily involved in the red zone here.
Auburn’s rushing defense hasn’t been tested much, yet its explosiveness rating sits around average even against weaker opponents. That’s a red flag with Oklahoma’s offense up next. Mateer has already proven he’s the Sooners’ go-to option near the goal line, and with Oklahoma favored to win, I expect multiple red-zone trips.
Given his rushing role and Auburn’s defensive concerns, Mateer finding the end zone feels like a strong bet. I’d comfortably play this to -175, as the odds suggest solid value compared to his expected usage and scoring chances in this matchup.
Auburn vs Oklahoma prop pick
Jackson Arnold Over 174.5 passing yards (-114 at FanDuel)
This play directly correlates with the under on his rushing yards. I expect Auburn to trail throughout, forcing Arnold to throw from the pocket rather than rely on his legs. That should lead to enough passing volume to clear this low number.
Arnold has topped this number only once, in a blowout win over Ball State when he ran for fewer than 10 yards. Oklahoma’s defense doesn’t have a glaring weakness, so this bet isn’t about matchup advantages. It’s about volume and game script. Auburn’s receivers are good enough to help him reach this mark if they’re playing from behind.
Michigan’s Bryce Underwood nearly cleared this total in his first true road start against Oklahoma with only nine completions. Auburn’s passing weapons are more dynamic, and I expect Arnold to throw enough to get there, especially if the Sooners force him into a pass-heavy approach.
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Auburn vs Oklahoma odds
Auburn vs Oklahoma game info
| Location: | Memorial Stadium, Norman, OK |
| Date: | Saturday, September 20, 2025 |
| Kickoff: | 3:30 p.m. ET |
| TV: | ABC |
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