The Saturday college football slate is packed with opportunities, and one of the best ways to capitalize is by targeting what we all love: touchdowns.
These anytime touchdown picks target players with the clearest paths to the end zone based on usage, matchup, and expected game script in Week 2.
Led by Lloyd Avant finding paydirt, here are my favorite college football picks for Sept. 12.
Best college football anytime touchdown picks for Week 2
| Pick |  Odds |
|---|---|
 Lloyd Avant |
+120 |
 Jamari Johnson |
+105 |
 Isaiah Horton |
+125 |
 Sam Leavitt |
-175 |
 Faizon Brandon |
+120 |
Pick #1: Lloyd Avant anytime touchdown +120
- Matchup: Oklahoma vs. Michigan
- Date/Time: Saturday, Sep. 12 at 12 p.m. ET
- Location: Michigan Stadium
- TV: FOX
Pick #2: Jamari Johnson anytime touchdown +105
Oregon tight end Jamari Johnson opened the season with four catches for 57 yards and a touchdown against Boise State after producing 32 catches for 510 yards and three scores in 2025.
Oklahoma State must devote coverage to Oregon’s perimeter weapons and rushing attack, creating openings for Johnson in the seams and near the goal line. His 6-foot-5 frame gives Dante Moore a natural red-zone target.
The Ducks are favored by 22.5 points after Moore threw for 378 yards and three touchdowns in the opener, giving them enough scoring opportunities for Johnson to remain involved. I like this all the way to 55%.
- Matchup: Oregon vs. Oklahoma State
- Date/Time: Saturday, Sep. 12 at 12 p.m. ET
- Location: Boone Pickens Stadium
- TV: ESPN
Pick #3: Isaiah Horton anytime touchdown +125
Isaiah Horton is the receiver I want from Texas A&M’s offense because his role is tied to the hardest area to defend: the red zone. The 6-foot-4 transfer opened the season with four catches for 76 yards and a touchdown, including a 15-yard score.
Horton’s size complements Mario Craver’s speed and gives Reed a clear back-shoulder or fade target when Arizona State compresses the field. The Aggies are 15.5-point home favorites with a 54.5 total, so multiple scoring opportunities are expected.
The Sun Devils' 70-7 opener came against Morgan State, making this a significant defensive step up and a test of its coverage depth. Playable to 42%.
- Matchup: Texas A&M vs. Arizona State
- Date/Time: Saturday, Sep. 12 at 12 p.m. ET
- Location: Kyle Field
- TV: ESPN
Pick #4: Sam Leavitt anytime touchdown -175
Sam Leavitt opened with 113 rushing yards and two rushing touchdowns against Clemson, tying Dilin Jones as the Tigers’ leading rusher while LSU generated a school-record 38 first downs.
Louisiana Tech’s 80-point opener came against Northwestern State, so this is a major step up in competition for the Bulldogs’ defense. That will show up in the massive difference in quality in the trenches and especially the red zone, where Leavitt’s mobility gives LSU an extra blocker and forces defenders to honor the quarterback keep.
LSU’s offensive line was also incredible in the opener. Leavitt’s designed carries should come early, before a potential fourth-quarter exit.
- Matchup: LSU vs. Louisiana Tech
- Date/Time: Saturday, Sep. 12 at 7:30 p.m. ET
- Location: Tiger Stadium
- TV: SEC Network
Pick #5: Faizon Brandon +120
Tennessee QB Faizon Brandon provides a path some may be overlooking. He scored two rushing touchdowns in the opener, but this pick should not be treated as a Furman-driven overreaction.
Brandon's five-star profile and mobility were part of his evaluation long before that game. Georgia Tech held Colorado to 14 points but allowed 183 rushing yards, and it now faces an offense that can stretch the field before attacking the interior with Brandon on designed keepers and scrambles.
Tennessee’s receivers should draw coverage outside, opening room for Brandon near the goal line.
- Matchup: Tennessee vs. Georgia Tech
- Date/Time: Saturday, Sep. 12 at 7 p.m. ET
- Location: Bobby Dodd Stadium
- TV: ESPN
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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