South Florida vs Memphis Prediction, Picks & Odds for Tonight's College Basketball Game

Rohit Ponnaiya - Betting Analyst at Covers.com
Rohit Ponnaiya • Betting Analyst +8 years betting experience
Updated: Mar 5, 2026 , 10:48 AM ET • 4 min read

Head coach Penny Hardaway is feeling the heat and that should lead to a heavily motivated performance from the Tigers on Senior Night.

NCAAB

Match starts: 6 hrs
USF
66 %
MEM
34 %
EXPERT PICK - SPREAD
Memphis +6.5 (-110) Memphis +6.5 (-110)
Read Analysis
Memphis Tigers college basketball Penny Hardaway Dug McDaniel
Photo By - Reuters Connect. Memphis Tigers head coach Penny Hardaway talks with guard Dug McDaniel.

The Memphis Tigers host the South Florida Bulls in their final home game of the regular season tonight.

The Bulls are clearly the better team, but my South Florida vs. Memphis predictions and college basketball picks are backing the home side. 

South Florida vs Memphis prediction

South Florida vs Memphis best bet: Memphis +6.5 (-110)

The Memphis Tigers are in a buy-low spot after going 0-6 SU and ATS in their last six games.

The Tigers are at home, where they've gone 10-5 this season, and they're in desperation mode. Coach Penny Hardaway is on the hot seat, and they can't afford another loss if they want to make the conference tournament. 

Meanwhile, the South Florida Bulls' stock is at a sell-high point, and they have little to play for since they've already clinched the regular season title and a tournament bye. Expect a low-effort performance from USF to result in a Memphis cover.

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South Florida vs Memphis same-game parlay

The Tigers play strong perimeter defense, forcing turnovers at the 43rd highest rate in the country while ranking 17th in opponent 3PT% (30%). They'll need to lean on that D if they want to be competitive, and that likely means the Under cashing. 

That elite 3-point defense should contain USF sharpshooter Joseph Pinion, who has hit fewer than 3.5 threes in eight of his last 10 games.

South Florida vs Memphis SGP

  • Memphis +6.5
  • Under 160.5
  • Joseph Pinion Under 3.5 threes

Our beyond the arc SGP: Dug from deep

USF defends the interior extremely well but is vulnerable at the arc, allowing the second-highest opponent 3PT% (35%) in conference play. Dug McDaniel leads Memphis in scoring (13.7 ppg) and threes (41), while knocking down two treys in back-to-back games.

South Florida vs Memphis SGP

  • Dug McDaniel Over 1.5 threes
  • Memphis +6.5
  • Under 160.5
  • Joseph Pinion Under 3.5 threes

South Florida vs Memphis odds

  • Spread: South Florida -6.5 | Memphis +6.5
  • Moneyline: South Florida -300 | Memphis +240
  • Over/Under: Over 160.5 | Under 160.5

South Florida vs Memphis betting trend to know

The Under has cashed in six straight games for the Bulls. Find more college basketball betting trends for South Florida vs. Memphis.

How to watch South Florida vs Memphis

Location FedExForum, Memphis, TN
Date Thursday, March 5, 2026
Tip-off 9:00 p.m. ET
TV ESPN2

South Florida vs Memphis key injuries

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Rohit Ponnaiya
Betting Analyst

With a background playing soccer, rugby, and boxing, combined with a journalism degree, it's little surprise that Rohit gravitated towards the world of sports betting. He specializes in betting on UFC and college basketball, two sports where the eyeball test can tell you a lot more about matchups than analytics. Rohit has years of experience handicapping NFL and NBA games as well as niche betting markets such as politics. He's also the resident CFL expert and formerly hosted "The Chez and Ro Show" with former CFL star Davis Sanchez.

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