Knicks vs Trail Blazers Prediction, Picks & Odds for Tonight’s NBA Game

James Bisson - Head of Content, Betting
James Bisson • Head of Content, Betting 16+ years betting experience
Updated: Mar 12, 2025 , 04:55 PM ET • 4 min read

Find out how our NBA betting picks see Karl-Anthony Towns and Josh Hart carrying the day for the Knicks against the Trail Blazers without Jalen Brunson to lean on.

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Mar 12 • 7:00 PM ET
New York Knicks NBA Karl-Anthony Towns
Photo By - Imagn Images. New York Knicks center Karl-Anthony Towns in NBA action.

The New York Knicks finally got back on track with their first win since Jalen Brunson’s injury, taking out the Sacramento Kings on Monday, and now have the opportunity to build some belief against a vulnerable Portland Trail Blazers team on the road.

With some injuries hitting Portland hard, our Knicks vs. Trail Blazers predictions will explain why New York should continue to hold strong defensively and earn a comfortable win.

Let’s dig into some NBA player props and hand out our best NBA picks for Wednesday, March 12.

Knicks vs Trail Blazers prediction

My best bet: Knicks -4 (-110 at bet365)

My analysis
The New York Knicks have lost a lot of their steam offensively without Jalen Brunson, but not all hope is lost. This team has still played Top 5 defense in the month of March, and judging by Brunson’s on/off splits there’s no reason why they can’t keep this up.

New York was able to suffocate a hot Kings offense on Monday to earn a much-needed win, leaning on the improvements Brunson’s absence will lead to in defending the mid-range, and now it will meet the eighth-worst offense this month.

The Portland Trail Blazers have leaned heavily on shots both at the rim and from the arc, but they continue to struggle with outside shooting and have now fallen off a cliff inside with the fourth-worst field goal percentage at the rim this month.

The Trail Blazers will continue to lack a presence in the frontcourt as long as Deandre Ayton remains out, and on top of that they will likely not have Jerami Grant at the power forward position and Robert Williams to shore up the center position.

We know the Knicks will be relying heavily upon Karl-Anthony Towns to score the ball in Brunson’s absence, and while the Trail Blazers have been excellent at defending the rim in Ayton’s absence, the other losses listed above will open the door for him to score the ball a bit better than forecasted.

New York’s remained committed to shooting the ball from deep, too, and against a Trail Blazers defense which has been abysmal around the arc, I believe this game should suit it quite well.

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Knicks vs Trail Blazers same-game parlay

Knicks -3.5

Josh Hart Over 1.5 made threes

Karl-Anthony Towns Over 2.5 assists

Josh Hart has now taken four or more 3-pointers in four straight games in an effort to work on his jumper in a seemingly lost period of the season for the Knicks — especially now that Brunson is hurt. He’s cashed in two times in his last three games, shooting 43.8% over that time, and will take aim at one of the worst perimeter defenses in basketball. 

Hart should be locked into big minutes here to make up for the loss of Brunson, and this is a sneaky way to bet on him.

Towns isn’t exactly known for his passing proficiency, but he’s now hit this number in two of his three games without Brunson this year and should be finding at least a little bit of resistance inside when Donovan Clingan is on the floor. With the 3-point line standing as the easiest avenue for offense, I expect him to kick the ball out into plenty of jumpers.

Learn how to bet a same-game parlay with these helpful tips and strategies.

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Knicks vs Trail Blazers odds

Knicks vs Trail Blazers live odds

Knicks vs Trail Blazers opening odds

  • Spread: New York -3.5 (-110) | Portland +3.5 (-110)
  • Moneyline: New York -185 | Portland +155
  • Over/Under: Over 226 (-110) | Under 226 (-110)

Odds courtesy of bet365

Knicks vs Trail Blazers spread and Over/Under analysis

  • This line was bouncing between Knicks -3.5 and -4 for most of the early window after reaching -4.5, but has since remained stagnant at -4.
  • The Knicks have taken on 68% of the bets and 72% of the handle wagered on the spread.
  • The total jumped up a point to 228 before spiking again and hitting 229. It’s since settled back at 228 with some slight movement towards the Under.
  • The Over has accounted for 62% of the tickets but just 21% of the money.

Knicks vs Trail Blazers trend

The Knicks have hit the 4Q Under in 15 of their last 20 away games (+9.30 Units / 41% ROI). Find more NBA betting trends for Knicks vs. Trail Blazers.

How to watch Knicks vs Trail Blazers

Location Moda Center, Portland, OR
Date Wednesday, 3-12-2025
Tip-off 10:00 p.m. ET
TV MSG, KUNP/KATU 2.2

Knicks vs Trail Blazers latest injuries

Not intended for use in MA.
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James Bisson
Head of Content, Betting

James Bisson is the Editor-in-Chief at Covers. He has been a writer, reporter and editor for more than 20 years, including a nine-year stint with The Canadian Press and more than five years at theScore. He has covered dozens of marquee events including the 2010 Winter Olympics, the 2006 Stanley Cup final and Wrestlemania 23, and his work has appeared in more than 200 publications, including the Los Angeles Times, the Guardian, Yahoo! Sports, the Toronto Star and The Globe and Mail.

His book, “100 Greatest Canadian Sports Moments”, was a hardcover best-seller in Canada in 2008 and earned him appearances on CBC Radio and Canada AM. He has written more than 50 sportsbook reviews, more than 200 industry news articles, and dozens of other sportsbook-related content articles.

A graduate of the broadcast journalism program at Ryerson University (now Toronto Metropolitan University), James has been an avid bettor since the early 2000s, and cites bet365 as his favorite sports betting site due to its superior functionality and quick payouts. His biggest professional highlight: Covering Canada's first Olympic gold medal on home soil – and interviewing Bret Hart. Twice.

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