NBA Opening Night Predictions, Odds & Picks: Knicks Edge LeBron & Co. on Banner Night

Jon Metler - Betting Analyst at Covers.com
Jon Metler • Betting Analyst 5+ years betting experience
Updated: Aug 11, 2026 , 06:22 PM ET • 4 min read

Madison Square Garden will be rocking for the defending champs on Opening Night, and the New York Knicks headline our favorite early NBA predictions for Tuesday, Oct. 20.

New York Knicks guard Jalen Brunson (11).
Photo By - Reuters Connect. New York Knicks guard Jalen Brunson (11).

The NBA has announced its Opening Night schedule, and it did not disappoint. 

LeBron James makes his Philadelphia 76ers debut on ring night at Madison Square Garden, while several other marquee matchups round out a loaded three-game slate in my early NBA picks for Tuesday, Oct. 20.

NBA Opening Night predictions

Pick DraftKings
Celtics Celtics +2.5 (-115) -115
Knicks Knicks -4.5 (-110) -110
Spurs Spurs -1.5 (-110) -110

The Celtics begin a new era led by Jayson Tatum. Meanwhile, Jaylen Brown and LeBron James make their 76ers debuts, the Knicks raise their championship banner, and the nightcap features the two teams with the shortest NBA Finals odds

How's that for an opening night?

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Celtics vs Pistons (3 p.m. ET, NBC)

Celtics vs Pistons opening odds

Celtics Celtics Pistons Pistons
+105 Moneyline -125
+2.5 (-115) Spread -2.5
Over 222.5 (-115) Total Under 222.5 (-105)

Celtics vs Pistons early pick: Celtics +2.5

-115 at DraftKings

I'll gladly take the Boston Celtics as an underdog against the Detroit PistonsThe Jaylen Brown-for-Paul George trade raised eyebrows, but this matchup shows its value.

George gives Boston another versatile perimeter defender who can switch onto Cade Cunningham and hold his own, even if Detroit uses actions to get Derrick White off Cunningham. 

76ers vs Knicks (7 p.m. ET, NBC)

76ers vs Knicks opening odds

76ers 76ers Knicks Knicks
+145 Moneyline -175
+4.5 (-110) Spread -4.5
Over 230.5 (-105) Total Under 230.5 (-115)

76ers vs Knicks early pick: Knicks -4.5

-110 at DraftKings

The Philadelphia 76ers are stacked and rightfully among the favorites to win it all, but I'm not backing them on opening night. 

Too many high-usage players need to mesh, while the New York Knicks bring continuity and familiarity — which is exactly what helped them win the title.

Thunder vs Spurs (9:30 p.m. ET, NBC)

Thunder vs Spurs opening odds

Thunder Thunder Spurs Spurs
+100 Moneyline -120
+1.5 (-110) Spread -1.5 (-110)
Over 230.5 (-110) Total Under 230.5 (-110)

Thunder vs Spurs early pick: Spurs -1.5

-110 at DraftKings

The San Antonio Spurs are a brutal matchup for the Oklahoma City Thunder, and nothing this offseason changed my mind. 

If anything, San Antonio widened the gap by adding Tobias Harris for depth, while Oklahoma City had to sacrifice key role players like Isaiah Joe, Lu Dort, and Aaron Wiggins to create cap space.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jon Metler
Betting Analyst

Having played, coached, and officiated basketball, Jon naturally turned his focus to the NBA when he entered the sports betting world. With over 15 years of experience, he specializes in spreads, moneylines, and player props—always chasing value through sharp market analysis. A firm believer in analytics, Jon trusts the numbers to guide his bets. He monitors NBA betting markets 365 days a year and uses 10-plus sportsbooks to find the best prices. If there are NBA games on, Jon’s up early, caffeinated, and already placing his favorite bets.

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