The Detroit Tigers will try to make it two in a row as Framber Valdez takes the mound for them against the San Diego Padres tonight.
Detroit looks to have a major pitching advantage in this one, which is why I’m taking it to win outright in my Tigers vs. Padres predictions.
Keep reading for my full MLB picks for Friday, March 27.
Tigers vs Padres predictions
Tigers vs Padres best bet: Tigers moneyline (+110)
Framber Valdez will make his Detroit Tigers debut tonight, and Detroit is expecting him to deliver the same performances he put together in Houston for the past few years.
Valdez has been one of the game’s best ground-ball pitchers, getting batters to hit it on the ground 61.5% of the time in his career.
The San Diego Padres will counter with Michael King, and should be concerned with his recent struggles. King threw to a 10.19 ERA and 1.868 WHIP this spring.
Unless he turns things around instantly, the Tigers should jump on King and win tonight.
COVERS INTEL: The Padres struggled against left-handed pitching in 2025, hitting just .244 with a .690 OPS against southpaws for the season.
Tigers vs Padres same-game parlay (SGP)
I’m backing the Tigers to win, and I’m pairing that with a couple player props to form a same-game parlay for tonight.
First, let’s take Valdez to hit the Over on his strikeout total. Valdez is averaging 8.8 strikeouts per nine innings, and hit the 5+ strikeout mark in 20 of his 31 starts last year.
I’ll also take Riley Greene to pick up his first hit of the year after taking an 0-for-4 in the season opener. Greene was one of Detroit's most important hitters in 2025, producing 36 homers and 111 RBI.
Tigers vs Padres SGP
- Tigers moneyline
- Framber Valdez Over 4.5 strikeouts
- Riley Greene to record a hit
Tigers vs Padres home run pick: Spencer Torkelson (+450)
These are generous odds on Spencer Torkelson to get off the mark with his first home run on Friday.
The Tigers 1B matched his career-high with 31 homers in 2025, and all signs are that his power was still there in spring training.
The longball played a big part in King’s struggles in the preseason, where he allowed nine homers in 17 2/3 innings of work. If that’s not entirely worked out as we move into the first weeks of the season, it makes King a great target for HR props.
- Best bets: 1-1, -0.28 units
- SGPs: 0-2, -2.00 units
- HR picks: 0-2, -2.00 units
Tigers vs Padres odds
- Moneyline: Detroit +110 | San Diego -130
- Run line: Detroit +1.5 | San Diego -1.5
- Over/Under: Over 7.5 | Under 7.5
Tigers vs Padres trend
The Padres were 4-7 straight up in King’s last 11 starts of the 2025 season. Find more MLB betting trends for Tigers vs. Padres.
How to watch Tigers vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Friday, March 27, 2026 |
| First pitch | 9:40 p.m. ET |
| TV | DSN, SDPA |
| Tigers starting pitcher | Framber Valdez (2025: 13-11, 3.66 ERA) |
| Padres starting pitcher | Michael King (2025: 5-3, 3.44 ERA) |
Tigers vs Padres latest injuries
Tigers vs Padres weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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