The New York Yankees are heavily favored to best the Cincinnati Reds in tonight's series opener, carrying -260 odds to win.
With a massive starting pitching advantage, my Reds vs. Yankees predictions and MLB picks see value backing New York to win by multiple runs.
Who will win Reds vs Yankees today: Yankees -1.5 (-125)
Rhett Lowder ranks in the 25th percentile or worse in xERA, xBA, strikeout rate, chase rate, and walk rate.
He allows a ton of quality contact, doesn’t miss bats, and control issues lead to a lot of additional traffic on the basepaths.
The New York Yankees are third in wOBA, second in OPS, and first in BB% against right-handed pitching at home — they are a perfect team to exploit Lowder’s shortcomings.
Cam Schlittler has already developed into an elite starter, and should have little problem against a Cincinnati Reds attack missing Elly De La Cruz.
Play Yankees -1.5 to -135.

Reds vs Yankees Over/Under pick: Under 8.5 (+100)
Schlittler has posted a 1.69 ERA over seven starts against teams ranking Bottom-15 in OPS vs. right-handed pitching. Only once did he concede more than a single run.
The Reds are a subpar offense against righties on the road, and the injury to De La Cruz only makes their life tougher.
The Yankees are missing Aaron Judge, Giancarlo Stanton, and Trent Grisham. Not to mention, Jazz Chisholm is nursing a groin issue.
It’ll be harder for them to run up the score without them. I also project they’ll only have eight innings to hit.
Play to -115.
- ML/RL bets: 34-27, -0.65 units
- Over/Under bets: 32-27-2, +1.69 units
Reds vs Yankees weather
It will be another warm day in New York, with temperatures expected to reach the 80s. That should boost the bats, although both teams are missing some of their top power sources.
Reds vs Yankees odds
- Moneyline: Reds +310 | Yankees -260
- Run line: Reds +1.5 (+105) | Yankees -1.5 (-125)
- Over/Under: Over 8.5 (-120) | Under 8.5 (+100)
Reds vs Yankees trend
New York has hit the Run Line in seven of the last 11 games (+4.4 units, 33% ROI). Find more MLB betting trends for Reds vs. Yankees.
How to watch Reds vs Yankees and game info
| Location | Yankee Stadium, Bronx, NY |
| Date | Friday, June 19, 2026 |
| First pitch | 7:05 p.m. ET |
| TV | Reds.TV, YES |
| Reds starting pitcher | Rhett Lowder (3-3, 4.60 ERA) |
| Yankees starting pitcher | Cam Schlittler (7-3, 1.82 ERA) |
Reds vs Yankees latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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