After a 1-0 Houston Astros win on Tuesday, the Philadelphia Phillies will look to punch back in a big way on Wednesday, June 25.
My Phillies vs. Astros predictions and MLB picks expect Kyle Schwarber & Co. to do just that against lefty Colton Gordon at Daikin Park in Houston.
Phillies vs Astros prediction
My Phillies vs Astros best bet: Colton Gordon Over 5.5 hits allowed (-120 at bet365)
⚾ Pick Analysis
Houston Astros left-hander Colton Gordon owns a 4.54 ERA with 44 hits allowed over 35 2/3 innings.
While southpaw Framber Valdez stymied the Philadelphia Phillies over seven shutout frames in Tuesday's 1-0 win, he's a completely different class of LHP.
The Phils rank ninth in MLB against lefty pitchers with a 107 wRC+ and eighth with a .739 OPS. Leading that charge is Kyle Schwarber, who, despite hitting left-handed, owns a 1.077 OPS with 12 home runs against southpaws in 2025.
Trea Turner and Nick Castellanos are each hitting over .300 vs. lefties, while Alec Bohm isn't far off (.275). Gordon isn't issuing many walks, so he's living in the strike zone, and opponents are making him pay with consistent contact — which includes a 20th percentile barrel rate.
Phillies vs Astros same-game parlay (SGP)
Colton Gordon Over 5.5 hits allowed
Kyle Schwarber to hit a home run
Phillies -1.5
🚀 SGP Analysis
Gordon's biggest bugaboo has been the home run ball, allowing eight across his seven starts.
Schwarber handles southpaws as well or better than he does righties, and he's one of baseball's most prolific deep threats. With Gordon unlikely to be wild, his middling fastball will see enough of the plate for Schwarber to unload.
Zack Wheeler counters Gordon on Philly's mound. The veteran righty has firmly established himself among baseball's elite during his Phillies tenure, and he's 7-2 with a 2.61 ERA in 2025.
Phillies vs Astros odds
Phillies vs Astros live odds
Phillies vs Astros opening odds
- Moneyline: Philadelphia -160 | Houston +135
- Run line: Philadelphia -1.5 (+115) | Houston +1.5 (-135)
- Over/Under: Over 7.5 (-115) | Under 7.5 (-105)
Phillies vs Astros trend
Colton Gordon has allowed six or more base hits in five of his seven outings in 2025. Find more MLB betting trends for Phillies vs. Astros.
How to watch Phillies vs Astros and game info
| Location | Daikin Park, Houston, TX |
| Date | Wednesday, 6-25-2025 |
| First pitch | 8:10 p.m. ET |
| TV | NBCSP, SCHN |
| Phillies starting pitcher | Zack Wheeler (7-2, 2.61 ERA) |
| Astros starting pitcher | Colton Gordon (2-1, 4.54 ERA) |
Phillies vs Astros latest injuries
Phillies vs Astros weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
