The New York Mets will work to salvage their postseason hopes as they host the San Diego Padres for a series opener at Citi Field tonight.
New York has struggled to put together wins and has an uncertain pitching situation tonight, leading me to take San Diego straight up in my Padres vs. Mets predictions.
Read below to dig deeper into tonight’s matchup with my free MLB picks on Tuesday, September 16.
Padres vs Mets prediction
Padres vs Mets best bet: Padres moneyline (+105)
The New York Mets finally picked up a win on Sunday over the Texas Rangers, snapping an eight-game losing streak and maintaining their tenuous hold on the final NL wild card. But things don’t get any easier in Queens, as the Mets will now host the San Diego Padres for three games.
One big concern for New York is its starting pitcher situation. The Mets will send Clay Holmes to the mound, and there have been some signs of fatigue for the former reliever down the stretch. Holmes has only gone beyond five innings in one of his last nine starts, and has allowed six earned runs on 11 hits over 8 2/3 innings of work in his last two outings.
The Mets will back up Holmes with Sean Manaea, who has been struggling himself, posting a 7.71 ERA since the start of August. And New York’s offense isn’t inspiring confidence either, averaging 2.78 runs over their last nine games.
Padres starter Michael King looked good enough in his return from injury last week for me to feel confident in him against the Mets tonight. I’m taking the Padres to win outright at plus money.
Padres vs Mets same-game parlay (SGP)
Along with taking the Padres to win, I’m expecting continued struggles from the New York offense tonight. That not only has me targeting the Under, but also King to cover Over 4.5 strikeouts, something he did in six of his last seven starts before his shoulder injury in May.
Padres vs Mets SGP
- Padres moneyline
- Under 8
- Michael King Over 4.5 strikeouts
Padres vs Mets odds
- Moneyline: San Diego +105 | New York -125
- Run line: San Diego -1.5 (+170) | New York +1.5 (-210)
- Over/Under: Over 8 (-105) | Under 8 (-115)
Padres vs Mets trend
The Mets are 1-8 straight up in their last nine games overall. Find more MLB betting trends for Padres vs. Mets.
How to watch Padres vs Mets and game info
| Location | Citi Field, Flushing, Queens |
| Date | Tuesday, September 16, 2025 |
| First pitch | 7:10 p.m. ET |
| TV | TBS |
| Padres starting pitcher | Michael King (4-2, 2.87 ERA) |
| Mets starting pitcher | Clay Holmes (11-8, 3.76 ERA) |
Padres vs Mets latest injuries
Padres vs Mets weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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