The Milwaukee Brewers have now won five in a row after taking the series opener against the visiting Padres.
It promises to be a pitchers’ duel for game two, but Milwaukee has its ace on the mound in Jacob Misiorowski.
It’s tough to imagine San Diego finding answers to its batting slump against the Miz. So, my Padres vs. Brewers predictions and MLB picks call for a Brewers victory on Wednesday, May 13.
Who will win Padres vs Brewers today: Brewers moneyline (-148)
The Milwaukee Brewers’ streak has an impressive level of difficulty. Their opponents in the five wins were all playoff teams with a combined 129-82, .611 record. For the season, Milwaukee has beaten winning teams two thirds of the time.
The San Diego Padres continue to flounder at the plate. They struck out 13 times and managed just eight hits on Tuesday, against a previously winless rookie starter, and their four-run output was above average for the recent stretch.
San Diego has been shut out as many times in the last 10 games as it has reached five runs (two each). Now they face Jacob Misiorowski.
COVERS INTEL: The Brewers pitchers have stepped up their performance against winning teams. They’re more than one run better (2.64 ERA, 1.092 WHIP, 11.6 K/9, .198 average against) compared to losing ones (3.81, 1.313, 9.0, .239).
Padres vs Brewers Over/Under pick: Under 7.5 (-133)
The last thing a slumping offense needs is to face MLB’s strikeout leader. Misiorowski has fanned 70 in 44 innings including 19 in the last 11.1.
He threw the seven fastest four-seamers in the pitch-tracking era in his last start and is 99th percentile in velocity and strikeout rate, 98th in swing-and-miss. And his breaking stuff ranks even higher than his fastball.
The Padres start Michael King, who has a 2.76 ERA and allows just 5.5 hits per nine innings. He hasn’t been as dominant as The Miz, but his stuff is in the top 12% of baseball, and his exit velocity and hard hit percentage allowed are both in the top 20%.
- ML/RL bets: 12-16 -3.26 units
- Over/Under bets: 16-16 -1.08 units
Padres vs Brewers odds
- Moneyline: San Diego +138 | Milwaukee -144
- Run line: San Diego +1.5 (-170) | Milwaukee -1.5 (+163)
- Over/Under: Over 7.5 (+127) | Under 7.5 (-133)
Padres vs Brewers trend
The San Diego Padres have hit the Game Total Under in 16 of their last 25 away games (+7.10 Units / 26% ROI). Find more MLB betting trends for Padres vs. Brewers.
How to watch Padres vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Wednesday, May 13, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | Padres.TV, Brewers.TV |
| Padres starting pitcher | Michael King (3-2, 2.76 ERA) |
| Brewers starting pitcher | Jacob Misiorowski (3-2, 2.45 ERA) |
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