Dodgers vs Astros Prediction, Picks & Odds for Today's MLB Game

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst 13+ years betting experience
Updated: May 4, 2026 , 03:46 PM ET • 4 min read

Ence's prediction: Ohtani, Dodgers destroy Astros bullpen.

MLB

Match starts: 4 hrs
LAD
64 %
HOU
36 %
EXPERT PICK - RUN LINE
LA Dodgers -1.5 (-125) LA Dodgers -1.5 (-125)
Read Analysis
Los Angeles Dodgers MLB Shohei Ohtani
Photo By - Reuters Connect. Los Angeles Dodgers designated hitter Shohei Ohtani.

The Los Angeles Dodgers and Houston Astros start a three-game series tonight when the teams meet at Daikin Park.

The Astros are dealing with a rash of injuries, which is why my Dodgers vs. Astros predictions have L.A. winning easily.

Here are my free MLB picks for Monday, May 4. 

Who will win Dodgers vs Astros today: Dodgers -1.5 (-125)

The Houston Astros have four starting pitchers injured at the moment, which is why Steven Okert is set to start in what will be a bullpen game.

Unfortunately for the Astros, their bullpen has posted a 6.69 ERA and 5.70 FIP over the past two weeks

It’s silly to expect them to suddenly turn things around against a loaded Los Angeles Dodgers lineup sporting the third-lowest strikeout rate over the past two weeks.

Houston’s offense is dealing with injuries as well, and will find it hard to score enough against Yoshinobu Yamamoto. The Dodgers will cover the spread here.

Covers COVERS INTEL: Over the last two weeks, Houston’ bullpen has allowed a 52.6% pull rate and 25% line drive rate, both among the worst marks in baseball.

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Dodgers vs Astros Over/Under pick: Over 9 (-115)

The Astros should not get blanked tonight, especially with hitters like Yordan Alvarez in the lineup. 

Yamamoto has been somewhat fortunate, given his xERA of 3.98 is more than a run higher than his 2.87 ERA.

Opponents are having real success vs. his four-seam fastball, slugging .548 vs. a .257 mark a season ago. He’s also having less success with his splitter, a pitch he utilizes 30% of the time. 

Shohei Otahni is due to break out, and likely will against this Houston bullpen. His .053 ISO and .214 BABIP over the past week are starkly at odds with his .348 xwOBA. 

Jason Ence's 2026 Transparency Record
  • ML/RL bets: 3-5, -2.42 units
  • Over/Under bets: 5-3, +1.91 units

Dodgers vs Astros odds

  • Moneyline: Dodgers -186 | Astros +178
  • Run line: Dodgers -1.5 | Astros +1.5
  • Over/Under: Over 9 | Under 9

Dodgers vs Astros trend

The Astros have hit the team total Over in 16 of their last 24 games at home (+6.95 Units / 24% ROI). Find more MLB betting trends for Dodgers vs. Astros.

How to watch Dodgers vs Astros and game info

Location Daikin Park, Houston, TX
Date Monday, May 4, 2026
First pitch 8:10 p.m. ET
TV SportsNet LA, SCHN
Dodgers starting pitcher Yoshinobu Yamamoto
(2-2, 2.87 ERA)
Astros starting pitcher Steven Okert
(0-0, 4.20 ERA)

Dodgers vs Astros latest injuries

Dodgers vs Astros weather

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jason Ence - Covers
Betting Analyst

Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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