The Chicago Cubs and Chicago White Sox split the first two games of their rivalry series, with both games featuring at least 11 runs.
My Cubs vs. White Sox predictions see another high-scoring affair coming, with the road team doing the heavy lifting.
Let's dive deeper into my MLB picks for Sunday, May 17.
Who will win Cubs vs White Sox today: Cubs moneyline (-130)
Erick Fedde owns an 0-4 record through six starts despite getting much better results than deserved.
His FIP (6.03) is 2.26 runs higher than his ERA (3.77). No other starting pitcher on today's slate has a FIP even 1.0 greater than their ERA.
Fedde has benefited from great batted ball luck (.208 BABIP), and been heavily reliant on it due to a low 14.7 K%.
He is very much playing with fire, and likely to get burned against a Chicago Cubs offense that ranks second in OBP and fourth in runs per game.
COVERS INTEL: The Cubs rank seventh in hard-hit rate against right-handed pitching on the road.
Cubs vs White Sox Over/Under pick: Over 8.5 (-115)
Fedde has benefited from a very soft schedule to date. He has only faced one team that ranks Top-10 in OBP, and he lasted just 14 outs while conceding three earned runs.
The Cubs rank Top-10 in almost every offensive category and should cause real problems for Fedde.
The Chicago White Sox are in a good spot to produce as well. Colin Rea ranks in the 15th percentile in xERA and has really struggled against lefties. That's not ideal going up against Colson Montgomery, Munetaka Murakami and a powerful offense reliant on its left-handed bats.
- ML/RL bets: 18-12, +1.63 units
- Over/Under bets: 14-15-1, -3.41 units
Cubs vs White Sox odds
- Moneyline: Cubs -130 | White Sox +110
- Run line: Cubs -1.5 (+125) | White Sox +1.5 (-145)
- Over/Under: Over 8.5 (-115) | Under 8.5 (-105)
Cubs vs White Sox trend
The Cubs have hit the moneyline in 22 of their last 30 games (+14.65 units, 38% ROI). Find more MLB betting trends for Cubs vs. White Sox.
How to watch Cubs vs White Sox and game info
| Location | Rate Field, Chicago, IL |
| Date | Sunday, May 17, 2026 |
| First pitch | 2:10 p.m. ET |
| TV | Marquee, CHSN |
| Cubs starting pitcher | Colin Rea (4-2, 4.68 ERA) |
| White Sox starting pitcher | Erick Fedde (0-4, 3.77 ERA) |
Cubs vs White Sox latest injuries
Cubs vs White Sox weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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