The Milwaukee Brewers visit the Pittsburgh Pirates at PNC Park for the second matchup of their four-game set, and a pair of aces will toe the rubber Friday, May 23.
My Brewers vs. Pirates predictions and MLB picks for tonight's Game 2 are headlined by Milwaukee starter Freddy Peralta and Pittsburgh star Paul Skenes.
Brewers vs Pirates prediction
My Brewers vs Pirates best bet: Freddy Peralta Over 16.5 Outs Recorded (-120 at DraftKings)
Milwaukee Brewers ace Freddy Peralta has quietly put together a sterling start to the season and lands in a favorable matchup with the Pittsburgh Pirates, packing minimal punch at the plate against righties.
Peralta has averaged 16.7 outs across his 10 starts with a solid 2.59 RA, 1.06 WHIP, and 4.05 xFIP. The veteran righty has also held opposing hitters to a minuscule 6.8 barrel percentage and 33.3% hard-hit rate.
There is likely to be some negative regression moving forward, with Peralta’s xFIP notably higher than his ERA. Still, his excellent track record includes posting a 3.77 ERA and 3.68 xFIP across 339 1/3 innings the past two years, so the potentially looming statistical correction won’t be crippling.
Of course, a real draw here is also the Pittsburgh offense, ranking 29th in wOBA and 30th in ISO against right-handed arms.
Look for Peralta to cruise through the Pirates at PNC Park tonight.
Brewers vs Pirates same-game parlay (SGP)
Under 7
Freddy Peralta Over 16.5 outs recorded
Paul Skenes 6+ strikeouts
Both Milwaukee and Pittsburgh have trended to the Under, and the Brewers have also struggled against right-handed pitchers with a 25th-ranked wOBA and 24th-ranked ISO.
As a result, I like Pirates ace Paul Skenes to deal and rack up strikeouts.
He’s recorded six or more punchouts in eight of 10 starts this season, and his 30.6 K% and 10.7 K/9 are both Top 10 marks among starters with at least 150 innings the past two years. His 2.12 ERA paces the majors, too.
Brewers vs Pirates odds
Brewers vs Pirates live odds
Brewers vs Pirates opening odds
- Moneyline: Milwaukee+107 | Pittsburgh -118
- Run line: Milwaukee +1.5 (-235) | Pittsburgh -1.5 (+180)
- Over/Under: Over 7 | Under 7
Brewers vs Pirates trend
The Milwaukee Brewers have hit the Under in 28 of their last 47 games (+10.45 Units / 20% ROI), and the Pittsburgh Pirates have hit the Under in 29 of their last 49 games (+10.30 Units / 19% ROI). Find more MLB betting trends for Brewers vs. Pirates.
How to watch Brewers vs Pirates and game info
| Location | PNC Park, Pittsburgh, PA |
| Date | Friday, 5-23-2025 |
| First pitch | 6:40 p.m. ET |
| TV | FDSNWI, SNP |
| Brewers starting pitcher | Freddy Peralta (5-3, 2.59 ERA) |
| Pirates starting pitcher | Paul Skenes (3-5, 2.44 ERA) |
Brewers vs Pirates latest injuries
Brewers vs Pirates weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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