Blue Jays vs Mariners Home Run Picks & Best Bets for ALCS Game 5

Our home run picks for Blue Jays vs. Mariners Game 5 are counting on a pair of stars in Vladimir Guerrero Jr. and Cal Raleigh to step up.

Quinn Allen - Betting Analyst at Covers.com
Quinn Allen • Betting Analyst
Oct 17, 2025 • 09:21 ET • 4 min read
Cal Raleigh Seattle Mariners MLB
Photo By - Imagn Images. Cal Raleigh celebrates with teammates.

We have a whole new series in the ALCS, as the Toronto Blue Jays have won two in a row against the Seattle Mariners to even things up heading into tonight’s Game 5.  

My Blue Jays vs. Mariners home run props and MLB picks for October 17 are predicting Vladimir Guerrero Jr. to go yard again this evening, while Cal Raleigh’s dominance against Kevin Gausman will continue. 

Blue Jays home run pick

Vladimir Guerrero Jr. (+400 at BetMGM)

While Vladimir Guerrero Jr. didn’t do a whole lot in Games 1 and 2 of the ALCS, he’s been brilliant overall in the playoffs. The slugger is batting .455 in the postseason with five home runs.

He’s left the ballpark in back-to-back games, and Guerrero Jr. has banged out six hits during that span. The Jays’ franchise star is on fire. 

While he’s only 1-for-7 lifetime against M’s starter Bryce Miller, Vladdy cannot be stopped right now. He’s swinging it with the utmost confidence, and the sample size against Miller isn’t big by any means. 

Guerrero Jr. is a power force, and he’ll make some more noise in Game 5. 

Mariners home run pick

Cal Raleigh (+260 at BetMGM)

As we know, Cal Raleigh led the big leagues in homers with 60 during the regular season. He’s carried that power into the playoffs, cracking three round-trippers so far. That includes two bombs in the ALCS.

Raleigh went deep in Game 3, and I’m eyeing him to do so in a crucial Game 5. 

Raleigh is 8-for-17 lifetime against Kevin Gausman with four home runs. He hit 38 of his regular-season bombs off right-handed pitchers, and he also put 28 in the bleachers at T-Mobile Park.

Seattle cannot afford to lose another here, and they will need The Big Dumper to step up and deliver. 

How to watch Blue Jays vs Mariners and Game 5 info

Location T-Mobile Park, Seattle, WA
Date Friday, October 17, 2025
First pitch 6:08 p.m. ET
TV FS1

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Quinn Allen - Covers
Betting Analyst

Quinn Allen is an experienced sports journalist from Vancouver, Canada who fell in love with sports by the time he could walk. He proceeded to play high-level baseball and soccer growing up and eventually played college baseball in the United States.

After his career ended, Quinn received his broadcast journalism degree from BCIT and has since written for many sports publications including ClutchPoints, Gino Hard, and RG, where he plies his trade as a writer and editor.

Quinn's favorite team is Chelsea FC and he'd like to watch a match at Stamford Bridge one day. He loves to bet on NBA player props and encourages others to bet responsibly and not chase losses.

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