A's vs Giants Picks and Predictions: Manaea Gives A's the Edge

The Bay Bridge Series renews tonight, with both Oakland and San Francisco among the best teams in the majors. Find out who has the edge for Friday's matchup with our A's vs. Giants picks.

Posted: Jun 25, 2021 1:20 PM ET Updated: Jun 25, 2021 7:00 PM ET Est Time: 4 min
Sean Manaea Oakland A's MLB
Photo By - USA TODAY Sports

The MLB betting board for Friday night is headlined by the Bay Bridge Series between the Oakland Athletics and San Francisco Giants.

Games between these interleague rivals are always fun and the stakes are even higher this year with both the A's and Giants currently near the top of the MLB standings. 

The Giants are slim +101 home underdogs for the first contest in this three-game set at Oracle Park. 

Here are our best free A's vs. Giants picks and predictions for Friday, June 25, with the opening pitch scheduled for 9:45 p.m. ET.

A's vs Giants game info

Location: Oracle Park, San Francisco, CA
Date: Friday, June 25, 2021
Time: 9:45 p.m. ET

A's vs Giants odds

Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.

Compare MLB odds before betting to ensure you get the best number.

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MLB sharp money and line movement report

By Patrick Everson

Oakland went up as a -120 favorite Thursday night at FanDuel, slipped to -110 overnight and is -118 at 7 p.m. ET. It's two-way moneyline action with a very modest lean toward the A's, who are drawing 52 percent of bets and 51 percent of cash. The total dropped from 8.5 to 7.5 and is now 8 (Under -115), with 73 percent of bets/89 percent of money on the Over. 

Check out the full line movement for this game

A's vs Giants betting preview

Starting pitchers

Sean Manaea (6-3, 3.01 ERA): Manaea is having an impressive year, pitching to a 3.01 ERA and 1.21 WHIP while fanning 89 batters across 86 2-3 starts.

The southpaw is coming off a strong outing against the Yankees where he struck out 11 batters and allowed three hits and two runs in 5 1-3 innings.

Johnny Cueto (5-3, 4.05 ERA): Cueto has been up-and-down this season. While the Giants have won seven of his 11 starts, he has pitched to a mediocre 4.05 ERA with a 1.32 WHIP in 60 innings.

The Dominican has an ugly 5.74 ERA with a 1.73 WHIP in three starts this month. 


Be sure to monitor the gametime conditions with our MLB weather info.

Key injuries

A's: Mark Canha RF (Questionable), Stephen Piscotty RF (Out).
Giants: Brandon Belt 1B (Questionable), Evan Longoria 3B (Out). 
Find our latest MLB injury reports.

Betting trend to know

The Over is 17-8-2 in the last 27 meetings between these California-based clubs. Find more MLB betting trends for A's vs. Giants.

Moneyline pick

Both of these teams are off to outstanding starts this year. The Giants have won 20 of their last 27 games and have the best record in the majors at 48-26. The A's are 15-6 in their last 21 games and, despite falling two games behind the Astros for first place in the AL West, have the third-best record in the majors at 46-31.

The Giants and A's have been mashing, with San Fran third in the majors with an OPS of .761, and the A's second in the majors in OPS on the road at .771. The big difference maker should be on the mound, where the A's will start Sean Manaea and the Giants will go with Johnny Cueto. 

Manaea has been the better pitcher this season and has been lights-out lately. In his last six starts, the lefty has pitched to a 1.19 ERA with a 1.06 WHIP, while allowing just one home run through 37 2-3 innings. 

Cueto ranks below the Top-250 starters in the majors in opponent batting average at .292 and he has allowed two homers in each of his last three starts. With the A's 4-0 in the last four meetings between these teams in San Francisco, back them again tonight. 

PREDICTION: ML Oakland (-109)

Over/Under pick

With Brandon Crawford and Buster Posey leading the way, the Giants are currently third in the majors in scoring with 5.03 runs per game. Led by Matt Olson and his 20 home runs, the A's have also enjoyed success at the plate, ranking sixth in the majors with 4.94 runs per game on the road. 

Despite dealing with an injury to star third baseman Evan Longoria, the Giants have been red-hot with the bat lately. Over the last 15 days, they have an OPS of .836 and they have plated a whopping 8.5 runs per game in their last eight contests. 

The A's have also been crushing the ball in recent weeks, posting a .827 OPS over the last 15 days and averaging 6.17 runs per game in their last 12 contests. They should be in for another big day against a struggling pitcher in Cueto.

The Over has cashed in five of the Giants' last six home games and the A's are 8-3 O/U in their last 11 games overall. Ride the sizzling sluggers on both sides and bet the Over.

PREDICTION: Over 7.5 (-112)

A's vs. Giants betting card

  • ML Oakland (-109)
  • Over 7.5 (-112)

Picks made on 6/25/2021 at 1 p.m. ET

MLB parlays

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