The Cleveland Guardians seek a series sweep when they host the Los Angeles Angels in Game 3 of their three-game set.
Cleveland starter Parker Messick has been a revelation, and my Angels vs. Guardians predictions expect a convincing Guardians victory today.
Read on for my MLB picks for Wednesday, May 13.
Who will win Angels vs Guardians today: Guardians -1.5 (+156)
The Cleveland Guardians send Parker Messick to the mound against a Los Angeles Angels lineup without many answers for left-handed pitching.
Messick owns a 2.30 ERA and 0.98 WHIP through eight starts, with his fastball-changeup combination generating elite run value on both pitches.
Three of the Angels' top four hitters rank among MLB's individual strikeout leaders, and Los Angeles owns the highest raw strikeout total in baseball with 419 on the season.
With Cleveland's bullpen pitching decently over the last two weeks, the plus-money value is there.
COVERS INTEL: The top of the Angels' lineup, Zach Neto (62), Mike Trout (49), and Jorge Soler (52) have combined for 163 strikeouts across 556 plate appearances.
Angels vs Guardians Over/Under pick: Under 7.5 (-108)
Two left-handed starters take the mound in Cleveland, and neither figures to allow much damage.
Messick ranks in the 85th percentile in chase rate with a 28.3% strikeout rate, while Reid Detmers owns a 2.90 xERA and a 91st-percentile breaking ball that neutralizes opposing lineups.
The Angels have struck out 115 times against left-handed pitching this season, while the Guardians lack much power against lefties, evidenced by their .148 ISO.
With two southpaws dealing and sharp money moving the total down to seven runs, a low-scoring affair is in the cards today.
- ML/RL bets: 6-11, -3.75 units
- Over/Under bets: 6-9, -4.30 units
Angels vs Guardians odds
- Moneyline: Angels +133 | Guardians -138
- Run line: Angels +1.5 (-170) | Guardians -1.5 (+163)
- Over/Under: Over 7.5 (+127) | Under 7.5 (-133)
Angels vs Guardians trend
The Under is 3-7 in the Los Angeles Angels' previous 10 games. Find more MLB betting trends for Angels vs. Guardians.
How to watch Angels vs Guardians and game info
| Location | Progressive Field, Cleveland, OH |
| Date | Wednesday, May 13, 2026 |
| First pitch | 1:10 p.m. ET |
| TV | Angels.TV, CLEGuardians.TV |
| Angels starting pitcher | Reid Detmers (1-3, 4.33 ERA) |
| Guardians starting pitcher | Parker Messick (4-1, 2.30 ERA) |
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Odds are correct at the time of publishing and are subject to change.
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