After 14 of 15 favorites won outright last week, NFL bettors face a different challenge in Week 10, with fewer large spreads and six divisional matchups on the schedule.
- Week 10 has fewer large spreads than Week 9, with six divisional matchups on the schedule.
- The 49ers and Lions are the two most popular teams to cover the spread at BetMGM.
- Amon-Ra St. Brown is attracting strong anytime touchdown betting interest ahead of Sunday's game in Munich.
Week 9 featured seven spreads of at least 5.5 points compared to just four in Week 10. That hasn't stopped BetMGM customers from backing the Lions and 49ers, both road favorites, more than any other teams this week.
Detroit is a 3-point favorite over the Patriots at BetMGM in Munich, Germany, on Sunday morning and is the most-bet team by handle. The Lions are getting 79% of the bets and 88% of the money at BetMGM. The over 50 total in Patriots-Lions is also the second most-bet total of the week.
Caesars Sportsbook reported Lions dominance as well.
BETTORS ARE HAMMERING DETROIT 🚨 81% of the Bets on Lions ML 73% of the Money on Lions ML 78% of the Bets on Lions Spread 92% of the Money on Lions Spread Everyone fading Drake Maye 😳 https://t.co/WfYK88CR1d
— Caesars Sportsbook (@CaesarsSports) November 13, 2026
DraftKings reported a smaller 66% of the handle and 74% of the tickets, but bettors typically bet the Lions every week.
The 49ers, one of the top two teams listed along with the Bills on Super Bowl winner odds boards, are 4.5-point road favorites against the popularly bet Cowboys, who aren’t so popular this week.
DraftKings reported that San Francisco is drawing 95% of the handle and 75% of the bets. At BetMGM, the 49ers are the most-bet team by tickets, getting 80% of the bets and 76% of the handle.
| Week 10 notable games | DraftKings spread splits | BetMGM spread splits |
|---|---|---|
 - (-3) |
DET 74% bets DET 66% handle |
DET 79% bets DET 88% handle |
 - (-3) |
GB 55% bets GB 65% handle |
GB 75% bets GB 70% handle |
 - (+3.5) |
SF 75% bets SF 95% handle |
SF 80% bets SF 76% handle |
 - (-3.5) |
CIN 61% bets PIT 62% handle |
CIN 52% bets PIT 52% handle |
Divisional showdowns
There are six divisional matchups that bettors have to navigate this week, creating what could be an advantageous situation for sportsbooks. These games are typically harder to decipher, but Vikings-Packers bettors think they’ve got it figured out.
Green Bay is drawing the majority of tickets and handle as a 3-point home favorite and ranks fourth in both categories at BetMGM. That’s understandable considering the Packers have won five of their last six. Minnesota, meanwhile, acquired quarterback Kirk Cousins before the trade deadline, adding another wrinkle to the matchup.
Bettors are split on Steelers-Bengals. Pittsburgh (+3.5) is drawing 62% of the handle at DraftKings, while Cincinnati has 61% of the tickets. BetMGM customers are also nearly evenly split between the two teams.
The Jaguars (-10.5) are the largest favorites this week and the third most-bet spread team by handle at BetMGM. The Bills, always a popular pick, are fifth-most-bet spread team as 7.5-point favorites at the Jets, who are getting just 23% of the tickets. Buffalo is getting 76% of the bets at DraftKings but a milder 52% of the money.
The Panthers have taken more than 60% of both the tickets and handle as 2.5-point favorites against the Saints at DraftKings, while bettors are split on Rams-Cardinals (+9.5).
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BetMGM totals, props
Most-bet total: Rams-Cardinals under 39.5, with rookie Carson Beck starting at QB for Arizona
Other popular totals: Texans-Browns over 40.5 and Chiefs-Falcons over 47
Most-bet anytime touchdown scorer: Amon-Ra St. Brown (-110)
Other popular anytime touchdown picks: Harold Fannin Jr. (+290) and Jameson Williams (+190)
Most-bet first touchdown scorer: Jahmyr Gibbs (+280)
Other popular first touchdown picks: St. Brown (+625)
