MLB Picks

Get free expert and computer MLB picks for every game on April 21, 2026. With over 25 years of betting experience, our analysts and predictive models help you find the best value.

Houston Astros logo HOU @ Cleveland Guardians logo CLE Tue, Apr 21 • 6:10 PM ET
3 Expert Picks 10 Computer Picks
Total
Houston Astros logo Cleveland Guardians logo o8.5 (+100)
Best Odds
Pick made: 2 hours ago
Phil Naessens image
Phil Naessens
Betting Analyst

Two possibly compromised starters, and two bullpens prone to the long ball. This game has runs written all over it. Messick boasts an xFIP that’s two runs higher than his ERA and is likely on a shorter leash. Weiss owns a 13.9% walk rate and has struggled to keep hitters off the bases all season. Neither bullpen is anything to trust. Cleveland’s bullpen allows 1.54 home runs per nine innings, while Houston’s relief corps gives up 1.89. With four of their previous six games going Over the total, we’ll back the bats in this one. 

Moneyline
Houston Astros logo HOU (+125)
Best Odds
Pick made: 2 hours ago
Phil Naessens image
Phil Naessens
Betting Analyst

Ryan Weiss doesn't need to be perfect today. He just needs to give the Houston Astros enough solid innings before their offense takes over. The Astros have the second-best offense in baseball with a 124 wRC+, while the Cleveland Guardians check in at exactly league average with a 100 wRC+. That gap matters late in a game when both starters are likely on short leashes; Parker Messick takes the hill after 112 pitches Thursday, while Weiss hasn’t gone more than 3 2/3 frames. Back the better bats in this one. 

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Cincinnati Reds logo CIN @ Tampa Bay Rays logo TB Tue, Apr 21 • 6:40 PM ET
10 Computer Picks
Total Hits
Richie Palacios logo
Richie Palacios u0.5 Total Hits (-115)
Projection 0.48
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 3 out of 5
The leading projection system (THE BAT X) projects Richie Palacios in the 15th percentile as it relates to his BABIP talent.. Richie Palacios is projected to hit 7th in the batting order in this matchup.. The #4 venue in the league for suppressing base hits to LHB, according to the leading projection system (THE BAT), is Tropicana Field.. Among all the teams on the slate today, the 3rd-best infield defense is that of the Cincinnati Reds.. In terms of his wOBA and overall offense, Richie Palacios has been lucky since the start of last season. His .377 figure has been a good deal higher than the leading projection system (THE BAT X)'s version of Statcast-based Expected wOBA (xwOBA) at .301.
Total Bases
Junior Caminero logo
Junior Caminero o1.5 Total Bases (+140)
Projection 1.72
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 3 out of 5
As it relates to his home run ability, Junior Caminero ranks in the 96th percentile according to the leading projection system (THE BAT X).. Junior Caminero is projected to bat 2nd in the batting order in this game.. The Tropicana Field roof is expected to be closed today, making the temperature in this contest 8° hotter than the average outdoor game of all games today — favorable for offense.. Junior Caminero pulls a high percentage of his flyballs (38.5% — 95th percentile) and will have a big advantage hitting them towards the league's 6th-shallowest LF fences in today's matchup.. Junior Caminero will benefit from the home field advantage in today's game, which ought to improve all of his stats.
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St. Louis Cardinals logo STL @ Miami Marlins logo MIA Tue, Apr 21 • 6:40 PM ET
10 Computer Picks
Total Hits
Kyle Stowers logo
Kyle Stowers u0.5 Total Hits (+182)
Projection 0.86
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 3 out of 5
The 4th-deepest RF fences among all stadiums are found in LoanDepot Park.. LoanDepot Park's elevation is near sea-level, one of the lowest in the league, which usually leads (as a rule of thumb) to worse offense.. Based on Statcast data, the leading projection system (THE BAT X)'s version of Expected Batting Average (.272) provides evidence that Kyle Stowers has had some very good luck since the start of last season with his .291 actual batting average.
Total Bases
Nolan Gorman logo
Nolan Gorman u1.5 Total Bases (-190)
Projection 0.75
Best Odds
Pick made: 44 minutes ago
EV Model Rating
Star rating: 4 out of 5
Nolan Gorman's batting average skill is projected to be in the 4th percentile according to the leading projection system (THE BAT X).. The leading projection system (THE BAT) projects LoanDepot Park as the 2nd-worst venue in Major League Baseball for left-handed home runs.. LoanDepot Park's elevation is near sea-level, one of the lowest in the league, which usually leads (as a rule of thumb) to worse offense.. Nolan Gorman pulls many of his flyballs (35.6% — 86th percentile) and will be challenged by MLB's 4th-deepest RF fences today.. Playing on the road generally weakens batter metrics across the board due to the lack of home field advantage, which ought to be the case for Nolan Gorman today.
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Milwaukee Brewers logo MIL @ Detroit Tigers logo DET Tue, Apr 21 • 6:40 PM ET
2 Expert Picks 10 Computer Picks
Total
Milwaukee Brewers logo Detroit Tigers logo u8.5 (-107)
Best Odds
Pick made: an hour ago
Shawn Krest image
Shawn Krest
Betting Analyst

Keider Montero and Kyle Harrison have suppressed offenses effectively this season, and neither the Brewers nor the Tigers has lit scoreboards on fire yet in 2026.

Moneyline
Detroit Tigers logo DET (-110)
Best Odds
Pick made: an hour ago
Shawn Krest image
Shawn Krest
Betting Analyst

The Brewers have too many key players (Jackson Chourio, Andrew Vaughn, Christian Yelich) on the injured list to counter Keider Montero. And while Kyle Harrison has been effective on the mound, he missed his last start with an injury and may not be 100%.

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New York Yankees logo NYY @ Boston Red Sox logo BOS Tue, Apr 21 • 6:45 PM ET
3 Expert Picks 10 Computer Picks
Total
New York Yankees logo Boston Red Sox logo o8.5 (-105)
Best Odds
Pick made: an hour ago
Chris Hatfield image
Chris Hatfield
Betting Analyst

Luis Gil's struggles will open the door for success for the Boston Red Sox, but the New York Yankees should be able to score, too. Connelly Early's 13% barrel rate, paired with an average exit velocity that’s actually worse than Gil's, is going to give the Bronx Bombers clear paths to run-scoring opportunities. I’d play this to 9.5 with a fair amount of confidence.

Moneyline
Boston Red Sox logo BOS (-115)
Best Odds
Pick made: an hour ago
Chris Hatfield image
Chris Hatfield
Betting Analyst

Luis Gil has posted some of the worst underlying metrics in 2026 to begin the season for any starting pitcher. The command issues that tanked his 2025 persist, and a 6.40 xERA suggests a player who has been more bad than unlucky. Boston has enough power in the lineup to hurt him. They’ve done it before, and the sixth-best hard-hit rate in the league looms large here. At a pick-em price, the Red Sox have the better matchup.

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Atlanta Braves logo ATL @ Washington Nationals logo WAS Tue, Apr 21 • 6:45 PM ET
1 Expert Pick 10 Computer Picks
Moneyline
Atlanta Braves logo ATL (-138)
Best Odds
Pick made: 2 hours ago
Joe Osborne image
Joe Osborne
Senior Betting Analyst

While both starting pitchers are off to solid starts, the gap between these offenses is significant, and Atlanta’s bullpen has been dominant. The Braves are 4-0 in Reynaldo Lopez’s outings, with Lopez allowing one earned run or fewer three times. He draws a Nationals lineup ranked 28th in OPS vs RHP over the last two weeks. Meanwhile, Foster Griffin faces a tough task against an Atlanta team that's 6-1 when facing lefty starters. The Braves are second in the majors in runs per game on the road.

Total Hits
Jorge Mateo logo
Jorge Mateo u0.5 Total Hits (+115)
Projection 0.53
Best Odds
Pick made: 40 minutes ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Jorge Mateo in the 15th percentile when assessing his overall offensive talent.. Jorge Mateo is projected to hit 9th in the batting order today.. The leading projection system (THE BAT) projects Nationals Park as the 4th-worst park in the game for right-handed batting average.. Nationals Park's altitude is near sea-level, one of the lowest in Major League Baseball, which tends to lead to lower offensive output.. As far as temperature and humidity go, the 3rd-most suitable pitching weather on the schedule is expected for this contest.
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Minnesota Twins logo MIN @ New York Mets logo NYM Tue, Apr 21 • 7:10 PM ET
10 Computer Picks
Total Bases
Byron Buxton logo
Byron Buxton o1.5 Total Bases (+150)
Projection 1.59
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 3 out of 5
Byron Buxton projects as the 12th-best home run batter in the league, according to the leading projection system (THE BAT X).. Byron Buxton is projected to bat 1st in the batting order today.. The wind projects to be blowing out to LF at 12.7-mph in this game, the 4th-most-favorable of the day for batters.. Byron Buxton pulls many of his flyballs (41.8% — 99th percentile) and sets up very well considering he'll be hitting them towards the game's 4th-shallowest LF fences in today's matchup.. Extreme flyball hitters like Byron Buxton generally hit better against extreme groundball pitchers like Nolan McLean.
Total RBIs
Matt Wallner logo
Matt Wallner o0.5 Total RBIs (+260)
Projection 0.43
Best Odds
Pick made: 2 minutes ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) ranks Matt Wallner as the majors's 14th-best home run batter.. Matt Wallner is projected to bat 5th on the lineup card in this matchup.. Citi Field has the shallowest centerfield dimensions among all major league stadiums.. The wind projects to be blowing out to LF at 12.7-mph in this game, the 4th-most-favorable of the day for batters.. Hitting from the opposite that Nolan McLean throws from, Matt Wallner will have the upper hand in today's game.
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Philadelphia Phillies logo PHI @ Chicago Cubs logo CHC Tue, Apr 21 • 7:40 PM ET
2 Expert Picks 10 Computer Picks
Moneyline
Chicago Cubs logo CHC (-120)
Best Odds
Pick made: 1 hours ago
Todd Cordell image
Todd Cordell
Betting Analyst

The Phillies have scored two runs or fewer in five consecutive games and it’s difficult to envision things getting much better tonight. Philadelphia’s offense has been putrid against left-handed pitching, sporting a .260 wOBA (28th) and .549 OPS (29th). They now have to deal with Shota Imanaga, who has been one of the league’s best starters thus far. While I believe Jesus Luzardo to be much better than his counting stats indicate, this is a tough matchup to truly get back on track. The Cubs rank third in both wOBA and OPS against left-handed pitchers, and recorded 12 hits the last time they faced Luzardo.

Total
Philadelphia Phillies logo Chicago Cubs logo u8.5 (-105)
Best Odds
Pick made: 1 hours ago
Todd Cordell image
Todd Cordell
Betting Analyst

Jesus Luzardo is sporting a painful 7.94 ERA despite striking out six batters for every walk issued and allowing hard contact just 28.6% of the time. He has a 1.93 xFIP and 2.45 SIERA, excellent numbers that suggest much better days are ahead. Shota Imanaga has been lights out to date with sparkling metrics in many categories (2.45 ERA, 2.49 xFIP, 12.68 K/9). With strong bullpens behind these two starters – both teams rank Top-10 in xFIP this month – it’s difficult to envision either team putting up a ceiling performance at the plate.

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Baltimore Orioles logo BAL @ Kansas City Royals logo KC Tue, Apr 21 • 7:40 PM ET
2 Expert Picks 10 Computer Picks
Game Prop
Baltimore Orioles logo Kansas City Royals logo YRFI/NRFI (No: +102)
Best Odds
Pick made: 2 hours ago
Neil Parker image
Neil Parker
Betting Analyst

The Orioles and Royals respectively rank third and last in percentage of games scoring a run in the first inning, so even with the wind forecasted to be howling out at Kauffman Stadium, I’m expecting starters Shane Baz and Kris Bubic to post zeros in the opening frame. Baltimore hasn’t scored an opening-inning run on the road all season, and Kansas City is the lowest-scoring team in the opening frame for the year and second-lowest scoring team overall, too.

Total Bases
Jeremiah Jackson logo Jeremiah Jackson o1.5 Total Bases (+115)
Best Odds
Pick made: 11 hours ago
Eric Rosales image
Eric Rosales
Betting Analyst

Jeremiah Jackson has ripped lefty pitching this season, going 7-for-14 (.500) with a HR and five RBI, with a .714 slugging percentage.

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Pittsburgh Pirates logo PIT @ Texas Rangers logo TEX Tue, Apr 21 • 8:05 PM ET
10 Computer Picks
Total Bases
Oneil Cruz logo
Oneil Cruz o1.5 Total Bases (+138)
Projection 1.89
Best Odds
Pick made: 22 minutes ago
EV Model Rating
Star rating: 4 out of 5
Oneil Cruz projects as the 11th-best home run hitter in the majors, per the leading projection system (THE BAT X).. Oneil Cruz is projected to bat 1st in the batting order in this matchup.. On average, the fence height at Globe Life Field is the 6th-lowest among all major league baseball stadiums.. The Globe Life Field roof figures to be closed today, making conditions in this contest 6° hotter than the average outdoor game of the day — favorable for offense.. Oneil Cruz will receive the benefit of the platoon advantage against Kumar Rocker in today's matchup... and moreover, Rocker has a large platoon split.
Total Bases
Joc Pederson logo
Joc Pederson u1.5 Total Bases (-240)
Projection 0.6
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Joc Pederson in the 6th percentile when assessing his BABIP talent.. Globe Life Field projects as the #30 field in Major League Baseball for run-scoring, according to the leading projection system (THE BAT).. In the league, Globe Life Field's CF dimensions are the 6th-deepest.. Joc Pederson has taken a step back with his Barrel%; his 9.8% rate last year has fallen off to 0% this season.. Joc Pederson's ability to hit the ball at a BABIP-optimizing launch angle (between -4° and 26°) has declined from last year to this one, falling from 39.5% to 25%.
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San Diego Padres logo SD @ Colorado Rockies logo COL Tue, Apr 21 • 8:40 PM ET
10 Computer Picks
Total Bases
Manny Machado logo
Manny Machado o1.5 Total Bases (+125)
Projection 2.18
Best Odds
Pick made: 1 hours ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Manny Machado in the 91st percentile when assessing his overall offensive talent.. Manny Machado is projected to bat 4th in the batting order in this game.. The #1 venue in baseball for boosting offensive stats, via the leading projection system (THE BAT), is Coors Field.. Built 5197 feet above sea level, Coors Field has the highest elevation among all major league stadiums, which generally leads to higher offensive output.. The weather report calls for the most suitable hitting weather of all games on the slate today, as it relates to temperature and humidity.
Total Bases
Jake Cronenworth logo
Jake Cronenworth o1.5 Total Bases (+182)
Projection 1.67
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Jake Cronenworth in the 77th percentile as it relates to his overall offensive ability.. The #1 venue in baseball for boosting offensive stats, via the leading projection system (THE BAT), is Coors Field.. Built 5197 feet above sea level, Coors Field has the highest elevation among all major league stadiums, which generally leads to higher offensive output.. The weather report calls for the most suitable hitting weather of all games on the slate today, as it relates to temperature and humidity.. The wind projects to be blowing out to LF at 11.5-mph in this contest, the 5th-most-favorable of the day for bats.
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Toronto Blue Jays logo TOR @ Los Angeles Angels logo LAA Tue, Apr 21 • 9:38 PM ET
3 Expert Picks 10 Computer Picks
Game Prop
Toronto Blue Jays logo Los Angeles Angels logo YRFI/NRFI (Yes: -120)
Best Odds
Pick made: 2 hours ago
Neil Parker image
Neil Parker
Betting Analyst

The top of the Los Angeles lineup has teed off on lefties, and Toronto southpaw Patrick Corbin sports a 5.46 ERA and 5.68 xERA dating back to 2021. Angels starter Jack Kochanowicz’s 3.47 ERA is well below his 5.09 xERA and respective 6.81 and 5.89 marks across 111 innings in 2025.

Total Home Runs
Kazuma Okamoto logo Kazuma Okamoto o0.5 Total Home Runs (+790)
Best Odds
Pick made: 4 hours ago
Josh Inglis image
Josh Inglis
Betting Analyst

Jack Kochanowicz is another arm to target on Dinger Tuesday. His command has been poor this year (15 walks in 23+ innings), and he also struggles to keep the ball in the park, allowing plenty of hard contact with the 14th-worst Blast Contact% since last season. He does generate ground balls, but when hitters elevate, it often leaves the yard — he had the highest HR/FB rate among MLB starters last year. Let’s back a name that has already cashed for us this season in Kazuma Okamoto, who brings strong home run metrics, especially in Blast Contact% and Ideal Attack Angle%. There’s some swing-and-miss, but the matchup is elite, and the price is right, with a breakeven around +650. It’s also a Top-10 park for right-handed power, and the wind blowing out only helps.

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Chicago White Sox logo CHW @ Arizona Diamondbacks logo AZ Tue, Apr 21 • 9:40 PM ET
10 Computer Picks
Total Bases
Munetaka Murakami logo
Munetaka Murakami u1.5 Total Bases (-165)
Projection 0.79
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 4 out of 5
In Major League Baseball, the 10th-highest fence height (on average) are at Chase Field.. Today, Munetaka Murakami is at a disadvantage facing the league's 3rd-deepest CF center field fences given that he hits his flyballs towards center field at a 39% rate (93rd percentile).. Playing on the road typically weakens hitter stats across the board due to the lack of home field advantage, which should be the case for Munetaka Murakami in today's game.. The leading projection system (THE BAT X) estimates Munetaka Murakami's true offensive talent to be a .342, providing some evidence that he has been very fortunate this year given the .042 discrepancy between that figure and his actual .384 wOBA.
Total Bases
Adrian Del Castillo logo
Adrian Del Castillo u1.5 Total Bases (-200)
Projection 0.78
Best Odds
Pick made: an hour ago
EV Model Rating
Star rating: 3 out of 5
In the majors, Chase Field's centerfield fences are the 3rd-deepest.. In Major League Baseball, the 10th-highest fence height (on average) are at Chase Field.. Typically, batters like Adrian Del Castillo who hit a lot of flyballs usually hit worse when facing pitchers who also induce a lot of flyballs such as Sean Burke.. In terms of his batting average, Adrian Del Castillo has experienced some positive variance since the start of last season. His .261 mark has been inflated compared to the leading projection system (THE BAT X)'s version of Statcast-based Expected Batting Average (xBA) at .201.. Adrian Del Castillo has shown bad plate discipline since the start of last season, checking in at the 12th percentile with a 6.06 K/BB rate.
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Athletics Athletics logo ATH @ Seattle Mariners logo SEA Tue, Apr 21 • 9:40 PM ET
10 Computer Picks
Total Bases
Nick Kurtz logo
Nick Kurtz o1.5 Total Bases (+155)
Projection 1.77
Best Odds
Pick made: 24 minutes ago
EV Model Rating
Star rating: 4 out of 5
Nick Kurtz projects as the 10th-best home run hitter in the majors, via the leading projection system (THE BAT X).. Nick Kurtz is penciled in 1st on the lineup card in this game.. T-Mobile Park has the 9th-lowest fences in Major League Baseball.. Nick Kurtz will have the handedness advantage against Luis Castillo today... and the cherry on top, Castillo has a large platoon split.. Nick Kurtz has a 91st percentile opposite-field rate on his flyballs (35.7%) and is a great match for the park considering he'll be hitting them in the direction of the game's 9th-shallowest LF fences in today's game.
Total Bases
Tyler Soderstrom logo
Tyler Soderstrom o1.5 Total Bases (+165)
Projection 1.64
Best Odds
Pick made: 2 hours ago
EV Model Rating
Star rating: 4 out of 5
When assessing his overall offensive ability, Tyler Soderstrom ranks in the 88th percentile according to the leading projections (THE BAT X).. Tyler Soderstrom is penciled in 4th on the lineup card in this game.. T-Mobile Park has the 9th-lowest fences in Major League Baseball.. Tyler Soderstrom will hold the platoon advantage over Luis Castillo in today's matchup... and even better, Castillo has a large platoon split.. Tyler Soderstrom has an 82nd percentile opposite-field rate on his flyballs (34%) and is a great match for the park considering he'll be hitting them out towards baseball's 9th-shallowest LF fences in today's game.
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Los Angeles Dodgers logo LAD @ San Francisco Giants logo SF Tue, Apr 21 • 9:45 PM ET
3 Expert Picks 10 Computer Picks
Total
Los Angeles Dodgers logo San Francisco Giants logo u7.5 (-125)
Best Odds
Pick made: 2 hours ago
JD Yonke image
JD Yonke
Betting Analyst

With temperatures in the mid-50s, it should be a pitcher-friendly environment. Yamamoto and Roupp have been two of the better starting pitchers in the league and should thrive. 

There are two quality bullpens behind them as well — L.A. ranks seventh in SIERA in relief (3.45) while San Francisco (3.55) isn’t far behind at ninth and has all of its top options well-rested and at the ready.

Moneyline
San Francisco Giants logo SF (+155)
Best Odds
Pick made: 2 hours ago
JD Yonke image
JD Yonke
Betting Analyst

Landen Roupp has been superb with a 2.57 xERA and 2.21 FIP, and most of his underlying metrics are actually better than Yoshinobu Yamamoto’s.

The lineup is due for significant positive regression as the likes of Rafael Devers (.581 OPS), Jung Hoo Lee (.658), and Heliot Ramos (.686) will likely rebound after slow starts.

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