Get free expert and computer MLB picks for every game on May 21, 2026. With over 25 years of betting experience, our analysts and predictive models help you find the best value.
CLE
@
DET
Thu, May 21 • 1:10 PM ET
u7.5 (-125)
CLE (+100)
The Tigers are missing three key players (Torres, Baez, Carpenter) and have fallen off a cliff, going 2-13 over their last 15 while scoring just 2.47 runs per game over that span.
The Guardians are hot with eight wins in their last nine and rank second in runs as well as third in OBP among all teams this month.
PIT
@
STL
Thu, May 21 • 1:15 PM ET
o7.5 (-110)
The Over has hit in four of the last five meetings between these clubs, and both pitchers have vulnerabilities. The Cardinals have previously hit Ashcraft well, while May is allowing hard contact at a career-worst rate. With Pittsburgh scoring 13 runs in the last two games and St. Louis’ bullpen posting a 4.53 ERA, runs should come from both sides.
PIT (-125)
Pittsburgh has all the momentum after a dominant 7-0 win on Wednesday, and Braxton Ashcraft continues to impress with a strong 2.16 road ERA. While Dustin May has struggled against the Pirates lineup and owns a shaky 4.50 home ERA, Pittsburgh’s offense is producing nearly five runs per game and should stay hot in the series finale.
NYM
@
WAS
Thu, May 21 • 4:05 PM ET
u8.5 (-115)
Let’s hammer the getaway Under with the New York Mets heading to Miami on Friday and the Washington Nationals traveling to Atlanta tonight. The weather is working in the Under’s favor with 10-mph winds blowing in, 60-degree temperatures, and some projected rain in the mix. Neither team is likely eager to grind through a getaway-day game, and we could see some quick at-bats with both clubs having all of their high-leverage bullpen arms available. THE BAT also backs the Under with a fair price of -153 and just 7.56 projected runs.
ATL
@
MIA
Thu, May 21 • 6:40 PM ET
ATL (-140)
TOR
@
NYY
Thu, May 21 • 7:05 PM ET
NYY (-160)
Carlos Rodón has some redemption on his mind after a shaky, costly return in the Subway Series for the New York Yankees. As they wrap up their current series against an AL East rival, he’ll need to capitalize on a Toronto Blue Jays lineup that’s hitting just .225 against left-handers this season. Rodón has a 2-3 record with an ERA of 4.72 and 54 strikeouts in 9 appearances against the Blue Jays in his career, but this Toronto team looks like a shell of themselves to start the season. Take the home team to best the Jays as Rodón shakes off the rust and slowly, but surely finds his rhythm again on the mound.
ATH
@
LAA
Thu, May 21 • 9:38 PM ET
ATH (-104)
José Soriano has struggled mightily against the Athletics, going 1-3 with a 9.00 ERA and 33 strikeouts in eight career outings — numbers that should have the AL West-leading A’s feeling confident heading into Thursday’s finale. It also sets the stage for Shea Langeliers, who’s been on fire with a .328 average, hitting .326 against right-handers and already launching 12 home runs this season. Expect Soriano to run into trouble again, with Langeliers likely playing a major role.
COL
@
AZ
Thu, May 21 • 9:40 PM ET
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