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MLB Picks

Get free expert and computer MLB picks for every game on Sept. 25, 2026.

New Computer Picks powered by Odds Shark

Predicted Score

CHC logo
CHC
CHC

4.94 @ 4.90

BOS
BOS logo
BOS

Cubs vs Red Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CHC logo
CHC
CHC

4.94

--

--

--

BOS logo
BOS
BOS

4.90

--

--

--

Tampa Bay @ Philadelphia
Matchup Stats

Predicted Score

TB logo
TB
TB

3.07 @ 4.67

PHI
PHI logo
PHI

Rays vs Phillies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TB logo
TB
TB

3.07

+136

o6.5 -113

+1.5 -170

PHI logo
PHI
PHI

4.67

-154

u6.5 +100

-1.5 +150

Pittsburgh @ Detroit
Matchup Stats

Predicted Score

PIT logo
PIT
PIT

4.29 @ 4.17

DET
DET logo
DET

Pirates vs Tigers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

PIT logo
PIT
PIT

4.29

-107

o7.5 -125

-1.5 +160

DET logo
DET
DET

4.17

-105

u8.5 -130

+1.5 -185

NY Mets @ Washington
Matchup Stats

Predicted Score

NYM logo
NYM
NYM

4.37 @ 4.73

WAS
WAS logo
WAS

Mets vs Nationals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

NYM logo
NYM
NYM

4.37

-130

o7.5 -137

-1.5 +130

WAS logo
WAS
WAS

4.73

+115

u8.5 -124

+1.5 -149

Cincinnati @ Toronto
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

3.49 @ 4.09

TOR
TOR logo
TOR

Reds vs Blue Jays · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CIN logo
CIN
CIN

3.49

+116

o7.5 -112

+1.5 -190

TOR logo
TOR
TOR

4.09

-134

u7.5 +100

-1.5 +172

Atlanta @ Miami
Matchup Stats

Predicted Score

ATL logo
ATL
ATL

4.35 @ 4.48

MIA
MIA logo
MIA

Braves vs Marlins · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

ATL logo
ATL
ATL

4.35

-124

o8.0 -110

-1.5 +135

MIA logo
MIA
MIA

4.48

+106

u8.5 -125

+1.5 -157

Cleveland @ Kansas City
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

4.24 @ 4.35

KC
KC logo
KC

Guardians vs Royals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CLE logo
CLE
CLE

4.24

-135

o7.5 -115

-1.5 +127

KC logo
KC
KC

4.35

+120

u8.0 -115

+1.5 -145

Colorado @ Chi. White Sox
Matchup Stats

Predicted Score

COL logo
COL
COL

3.85 @ 4.77

CHW
CHW logo
CHW

Rockies vs White Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

COL logo
COL
COL

3.85

+194

o7.5 -130

+1.5 -114

CHW logo
CHW
CHW

4.77

-225

u8.5 -125

-1.5 +100

St. Louis @ Milwaukee
Matchup Stats

Predicted Score

STL logo
STL
STL

3.64 @ 4.38

MIL
MIL logo
MIL

Cardinals vs Brewers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

STL logo
STL
STL

3.64

+151

o8.0 -115

+1.5 -140

MIL logo
MIL
MIL

4.38

-172

u8.5 -120

-1.5 +130

Texas @ Minnesota
Matchup Stats

Predicted Score

TEX logo
TEX
TEX

4.26 @ 4.13

MIN
MIN logo
MIN

Rangers vs Twins · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TEX logo
TEX
TEX

4.26

-108

o7.5 -115

-1.5 +160

MIN logo
MIN
MIN

4.13

-108

u7.5 -103

+1.5 -182

Houston @ Athletics
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

6.74 @ 5.33

ATH
ATH logo
ATH

Astros vs Athletics · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

HOU logo
HOU
HOU

6.74

--

--

--

ATH logo
ATH
ATH

5.33

--

--

--

Arizona @ San Diego
Matchup Stats

Predicted Score

AZ logo
AZ
AZ

4.23 @ 4.19

SD
SD logo
SD

Diamondbacks vs Padres · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

AZ logo
AZ
AZ

4.23

+116

o7.0 -119

+1.5 -190

SD logo
SD
SD

4.19

-132

u7.5 -112

-1.5 +175

Cleveland Guardians image thumbnail CLE @ Kansas City Royals image thumbnail KC Fri, Sep 25 • 7:40 PM ET
Moneyline
Cleveland Guardians image thumbnail CLE (-137)
Best Odds
Pick made: an hour ago
Chris Vasile logo
Chris Vasile
Publishing Editor

I’m backing Cleveland behind Gavin Williams, who enters with a 3.63 ERA, 1.08 WHIP, and 244 strikeouts in 181 innings. Kansas City counters with Noah Cameron, but the bigger edge comes once the starters leave. The Royals’ bullpen has been a problem all season, while Cleveland owns a 3.75 team ERA. With the Guardians still fighting for the AL Central, I’ll trust the better pitching staff in a meaningful game.

View Pick
Arizona Diamondbacks image thumbnail AZ @ San Diego Padres image thumbnail SD Fri, Sep 25 • 9:40 PM ET
Moneyline
Arizona Diamondbacks image thumbnail AZ (+116)
Best Odds
Pick made: an hour ago
Jon Metler logo
Jon Metler
Betting Analyst

The Arizona Diamondbacks are trading at 46% on Polymarket, and I'm hitting the button at that price, as I make them closer to 50% against the San Diego Padres. You can't have your back against the wall much more than the Diamondbacks do this weekend, as they basically need a sweep to have any hope of making the postseason. That should lead to their roster being managed like they're playing an elimination game, but I also really like the matchup for Brandon Pfaadt. The heart of the Padres' lineup is loaded with right-handed bats, and that's not a problem for Pfaadt, who has held right-handed hitters to a .599 OPS this season. His hard, sweeping slider runs away from the barrels of right-handed hitters, giving him a pitch that can neutralize the strength of San Diego's lineup. That's why the Diamondbacks have my attention at this price.

View Pick

What Is An MLB Computer Pick?

MLB picks are bet suggestions based on our computer's assessment of the game. Tons of betting data goes into a computer pick, including pitching matchups, injury reports, analytics, and even recent betting trends.

How To Use MLB Computer Picks

You can use the tables above to help with your bets during the MLB season. The first section includes free, computer-generated picks for daily Major League Baseball games. Baseball bettors can choose to follow the computer, fade the computer, or simply use our computer picks as one element of their betting strategy.

This page also tees up access to deeper betting trends. For example, if a club's run line is favored, you can check their ATS trends, potentially opening up some quality underdog bets.

If you're ready to get started with MLB betting, visit our dedicated page highlighting the best MLB betting sites.

Moneyline

This is the most common and easiest wager for a bettor to make when it comes to MLB picks. Basically, to win an MLB moneyline pick, you just have to choose which team will win the game.

It's simple: if you bet the White Sox moneyline over the Red Sox and Chicago wins, you win your bet.

Run line

The run line is another name for a point spread that you may be more familiar with in NBA and NFL betting. A point spread varies in the NFL and NBA from as little as 0.5 points up to double-digit spreads. A baseball run line is almost always a 1.5-point spread.

The favorite will be -1.5 while the underdog will be +1.5. At the end of the game, if you take away 1.5 runs from the favorite or add 1.5 runs to the underdog and they end up winning the game, you win your MLB pick against the spread.

Totals (Over/Under)

Another common wager is to bet on the total in baseball, which is a bet on the total runs scored in the baseball game. You are simply choosing whether the final score will be Over or Under that total. Betting the Over/Under on a matchup is a great way to get started in MLB score predictions.

Free Computer Picks by Odds Shark

More MLB Picks & Betting Tools

NRFI/YRFI MLB Picks

A new and emerging MLB betting market is the NRFI/YRFI bet. These are quick-hitters in which you make a wager on the O/U total of the first inning, typically set at 0.5 runs. Thus, the bet is coined as No Run First Inning or Yes Run First Inning. No need to wait a couple of hours to cash a bet when it could be done in 20 minutes or less.

First Five Innings MLB Picks

The above options, moneyline, run line, and Over/Under, can also be placed on the first five innings of a game rather than the full game. Many experienced bettors will use this approach because, typically, this will take bullpens out of the equation and make your job researching the game easier. After all, you can just focus on the starting pitchers.

MLB Picks And Parlays

If you want to combine multiple games into one mega wager, you may consider making a parlay bet. A parlay is when you pick two or more MLB games on one single betting ticket, which will increase the payout of your bet.

But it also comes with more risk, as each of those MLB picks must hit for your ticket to pay out. Our parlay calculator is a great tool to find out what your potential payout would be.

If you're looking for more MLB picks content, check out our consensus picks and prop bets pages to get your fix. While you're at it, head over to our MLB promos page to get the best bang for your buck.

MLB Player Props

Player props are a great way to hone in on an individual matchup for a game. These types of wagers will be individualized for a player: Will Shohei Ohtani hit a home run? Will Gerrit Cole get seven strikeouts? Will Paul Skenes allow two earned runs?

You simply choose whether this outcome will happen or not. Keeping up to date on daily pitching matchups and batters on a hot streak can give you a huge boost when placing player prop bets.

MLB Futures Picks

Lastly, prior to the season and even throughout the season, you can place futures bets on all the long-term awards and outcomes. You can lock in an MLB pick on who will win their division, which squad will win the World Series, or even who will win the Rookie of the Year, MVP, or Cy Young.

MLB Free Picks FAQs

When do we release our MLB picks?

Covers’ MLB picks release on game day. Some significant matchups like playoff games release in the days leading up to the game.

What kinds of MLB picks do we make?

Covers provides free MLB picks covering many markets, including run lines, totals, moneylines, player props, and more.