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MLB Picks

Get free expert and computer MLB picks for every game on Sept. 21, 2026.

New Computer Picks powered by Odds Shark

Predicted Score

TOR logo
TOR
TOR

4.07 @ 4.08

BAL
BAL logo
BAL

Blue Jays vs Orioles · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TOR logo
TOR
TOR

4.07

-103

o7.5 +100

-1.5 +175

BAL logo
BAL
BAL

4.08

-105

u7.5 -113

+1.5 -180

Washington @ Detroit
Matchup Stats

Predicted Score

WAS logo
WAS
WAS

4.52 @ 4.29

DET
DET logo
DET

Nationals vs Tigers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

WAS logo
WAS
WAS

4.52

+116

o8.5 -104

+1.5 -179

DET logo
DET
DET

4.29

-130

u8.5 -105

-1.5 +153

Minnesota @ San Francisco
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

4.84 @ 3.91

SF
SF logo
SF

Twins vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIN logo
MIN
MIN

4.84

-120

o8.0 -125

-1.5 +140

SF logo
SF
SF

3.91

+108

u8.5 -112

+1.5 -160

Tampa Bay @ NY Yankees
Matchup Stats

Predicted Score

TB logo
TB
TB

3.35 @ 4.44

NYY
NYY logo
NYY

Rays vs Yankees · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TB logo
TB
TB

3.35

+113

o7.0 -105

+1.5 -199

NYY logo
NYY
NYY

4.44

-130

u7.5 -142

-1.5 +175

Toronto @ Baltimore
Matchup Stats

Predicted Score

TOR logo
TOR
TOR

4.39 @ 4.50

BAL
BAL logo
BAL

Blue Jays vs Orioles · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TOR logo
TOR
TOR

4.39

+102

o7.5 -110

+1.5 -200

BAL logo
BAL
BAL

4.50

-120

u7.5 -104

-1.5 +169

Washington @ Detroit
Matchup Stats

Predicted Score

WAS logo
WAS
WAS

3.89 @ 4.24

DET
DET logo
DET

Nationals vs Tigers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

WAS logo
WAS
WAS

3.89

+138

o8.5 -103

+1.5 -160

DET logo
DET
DET

4.24

-155

u8.5 -115

-1.5 +146

Milwaukee @ Philadelphia
Matchup Stats

Predicted Score

MIL logo
MIL
MIL

3.70 @ 4.37

PHI
PHI logo
PHI

Brewers vs Phillies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIL logo
MIL
MIL

3.70

+120

o7.0 -120

+1.5 -185

PHI logo
PHI
PHI

4.37

-139

u7.5 -120

-1.5 +165

St. Louis @ Pittsburgh
Matchup Stats

Predicted Score

STL logo
STL
STL

4.05 @ 4.28

PIT
PIT logo
PIT

Cardinals vs Pirates · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

STL logo
STL
STL

4.05

+126

o7.0 -120

+1.5 -170

PIT logo
PIT
PIT

4.28

-145

u7.5 -120

-1.5 +154

Cleveland @ Boston
Matchup Stats

Predicted Score

CLE logo
CLE
CLE

3.71 @ 3.70

BOS
BOS logo
BOS

Guardians vs Red Sox · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CLE logo
CLE
CLE

3.71

+110

o6.5 -120

+1.5 -205

BOS logo
BOS
BOS

3.70

-125

u7.0 -120

-1.5 +173

Tampa Bay @ NY Yankees
Matchup Stats

Predicted Score

TB logo
TB
TB

3.32 @ 3.79

NYY
NYY logo
NYY

Rays vs Yankees · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

TB logo
TB
TB

3.32

+116

o6.5 -118

+1.5 -200

NYY logo
NYY
NYY

3.79

-134

u7.0 -125

-1.5 +180

Cincinnati @ Atlanta
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

4.85 @ 5.30

ATL
ATL logo
ATL

Reds vs Braves · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CIN logo
CIN
CIN

4.85

+158

o8.5 -138

+1.5 -136

ATL logo
ATL
ATL

5.30

-184

u9.5 -120

-1.5 +125

Chi. White Sox @ Kansas City
Matchup Stats

Predicted Score

CHW logo
CHW
CHW

4.73 @ 4.17

KC
KC logo
KC

White Sox vs Royals · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

CHW logo
CHW
CHW

4.73

-112

o7.5 -125

-1.5 +150

KC logo
KC
KC

4.17

+100

u8.5 -132

+1.5 -170

Miami @ Chi. Cubs
Matchup Stats

Predicted Score

MIA logo
MIA
MIA

3.53 @ 4.02

CHC
CHC logo
CHC

Marlins vs Cubs · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIA logo
MIA
MIA

3.53

--

--

--

CHC logo
CHC
CHC

4.02

--

--

--

NY Mets @ Texas
Matchup Stats

Predicted Score

NYM logo
NYM
NYM

4.48 @ 4.64

TEX
TEX logo
TEX

Mets vs Rangers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

NYM logo
NYM
NYM

4.48

+122

o7.5 -110

+1.5 -165

TEX logo
TEX
TEX

4.64

-140

u8.5 -128

-1.5 +146

Arizona @ Colorado
Matchup Stats

Predicted Score

AZ logo
AZ
AZ

6.30 @ 5.13

COL
COL logo
COL

Diamondbacks vs Rockies · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

AZ logo
AZ
AZ

6.30

-190

o10.5 -142

-1.5 -120

COL logo
COL
COL

5.13

+165

u11.5 -125

+1.5 +105

Houston @ Seattle
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

4.15 @ 4.60

SEA
SEA logo
SEA

Astros vs Mariners · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

HOU logo
HOU
HOU

4.15

+124

o7.5 -110

+1.5 -169

SEA logo
SEA
SEA

4.60

-140

u8.0 -120

-1.5 +150

LA Angels @ Athletics
Matchup Stats

Predicted Score

LAA logo
LAA
LAA

5.59 @ 5.23

ATH
ATH logo
ATH

Angels vs Athletics · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

LAA logo
LAA
LAA

5.59

-108

o9.5 +101

-1.5 +150

ATH logo
ATH
ATH

5.23

-108

u9.5 -110

+1.5 -175

Minnesota @ San Francisco
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

4.62 @ 3.60

SF
SF logo
SF

Twins vs Giants · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

MIN logo
MIN
MIN

4.62

-130

o7.5 -110

-1.5 +130

SF logo
SF
SF

3.60

+115

u7.5 -108

+1.5 -155

San Diego @ LA Dodgers
Matchup Stats

Predicted Score

SD logo
SD
SD

4.81 @ 5.07

LAD
LAD logo
LAD

Padres vs Dodgers · Prediction & Game Odds

Team

Predicted Score

ML

Total

Run Line

SD logo
SD
SD

4.81

--

--

--

LAD logo
LAD
LAD

5.07

--

--

--

Toronto Blue Jays image thumbnail TOR @ Baltimore Orioles image thumbnail BAL Mon, Sep 21 • 6:35 PM ET
Total Home Runs
Coby Mayo logo Coby Mayo o0.5 Total Home Runs (+449)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

Coby Mayo has some batter-vs-pitcher numbers in his favor as the only Oriole to take Trey Yesavage deep over five plate appearances. The Toronto starter is coming off the 15-day IL after being out since early August and has made just one rehab start. The Jays are desperate, and Yesavage might not be in the best form after going just two outs in his only rehab game. His leash could be three innings at most. Mayo is hitting out of the four-hole and has five homers over his last 12 games. This is a hot stick at a great price on a short slate against what could be 21 outs from the Toronto bullpen, which used seven arms yesterday. The wheels are falling off the Jays as the finish line approaches.

Total Home Runs
Nathan Lukes logo Nathan Lukes o0.5 Total Home Runs (+900)
Best Odds
Pick made: 5 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Let's double down on Lukes and this value - at +900, he's absolutely the best bet on the board tonight. Aside from owning a .307 xBA in this matchup, Lukes has a .551 xSLG against Baz, which is the highest on the team for everyone not named Vladimir Guerrero Jr. He's seeing the ball well, too, coming off a 2-for-3, two-RBI night and has hit nine of his 10 homers this year off righties.

View 16 Picks
Washington Nationals image thumbnail WAS @ Detroit Tigers image thumbnail DET Mon, Sep 21 • 6:40 PM ET
Total Home Runs
CJ Abrams logo CJ Abrams o0.5 Total Home Runs (+575)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

It's tough for me to say no to CJ Abrams at 6x or better today. River Ryan is starting for the Tigers and was a key piece in the Tarik Skubal deal, but also missed three months with a hamstring injury. This is not a long leash and is more of an opener to Keider Montero. Ryan pitched to a 4.46 ERA for the Dodgers at Triple-A before the trade and was giving up more than one hit per inning. I don't understand the Tigers' love on this moneyline today, but it is giving value to Washington run props because of a projected lower team total. Abrams might have been the biggest ROI home-run hitter in baseball this year, and one more day to add to those breakout numbers, with 12-mph winds blowing out to his pull side, sure makes this 6x or better home run on a small slate look good.

Hits+Runs+RBIs
James Wood logo James Wood o1.5 Hits+Runs+RBIs (-114)
Best Odds
Pick made: 5 hours ago
Colby Marchio logo
Colby Marchio
Contributor

James Wood gets a favorable matchup against Tigers right-hander Keider Montero, who has been getting crushed by left-handed hitters lately. Over his last three games, lefties own a .323 xBA, .584 xSLG and .387 xwOBA against him while generating a 46%+ hard-hit rate. Wood has also been making plenty of hard contact, with three of his last five batted balls leaving the bat at over 103.9 mph. Over his last 30 at-bats against right-handed pitching, Wood owns a .433 OBP and a 66%+ hard-hit rate. He also carries the No. 1 Batters-Box rating tonight.

View 19 Picks
Minnesota Twins image thumbnail MIN @ San Francisco Giants image thumbnail SF Mon, Sep 21 • 9:45 PM ET
Total Home Runs
Drew Gilbert logo Drew Gilbert o0.5 Total Home Runs (+900)
Best Odds
Pick made: 2 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

This is the best +EV homer on the board, with a fair price of 7.8x. Gilbert gets Zebby Matthews, whose HR/9 numbers over the last two years make him a great HR target, even on the small slate. Gilbert has cashed some long-odds homers over the past two weeks at 10x and better. He's a righty-platoon guy who doesn't see many left-handed pitchers, but Matthews has a 100-pitch leash, and the Twins' bullpen has stronger righty options than lefties. On a three-game slate, it's time to trust the projections even more.

Strikeouts Thrown
Zebby Matthews logo Zebby Matthews o4.5 Strikeouts Thrown (-116)
Best Odds
Pick made: 5 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

It's slim pickings on the K front today, but Zebby Matthews is still getting 95-plus pitches and is coming off an eight-strikeout start. His innings aren't massive this year, so there's less likely a chance of scaling him back in what will be his last start. The Minnesota starter also gets the confines of Oracle Park and a Giants lineup that has had a Top-10 K% all season. I wouldn't be running this much past -125 today, but if you want to take a swing, the Alt Over is in the range of outcomes for Matthews, who has collected 7-plus Ks in 30% of his last 10 starts.

View 18 Picks
Tampa Bay Rays image thumbnail TB @ New York Yankees image thumbnail NYY Tue, Sep 22 • 1:05 PM ET
Total RBIs
Austin Wells logo
Austin Wells o0.5 Total RBIs (+305)
Projection 0.41
Best Odds
Pick made: 4 months ago
EV Model Rating
Star rating: 4 out of 5
Yankee Stadium ranks as the #7 ballpark in the majors for left-handed home runs, per the leading projection system (THE BAT).. Yankee Stadium has the 7th-lowest average fence height among all parks.. Hitting from the opposite that Drew Rasmussen throws from, Austin Wells will have an edge in today's matchup.. Extreme flyball batters like Austin Wells generally hit better against extreme groundball pitchers like Drew Rasmussen.. The Tampa Bay Rays infield defense grades out as the 2nd-weakest among every team on the slate today.
Total RBIs
Cody Bellinger logo
Cody Bellinger o0.5 Total RBIs (+206)
Projection 0.55
Best Odds
Pick made: 4 months ago
EV Model Rating
Star rating: 4 out of 5
The leading projection system (THE BAT X) projects Cody Bellinger in the 89th percentile when it comes to his overall offensive talent.. Cody Bellinger is projected to hit 4th in the lineup in today's game.. Yankee Stadium ranks as the #7 ballpark in the majors for left-handed home runs, per the leading projection system (THE BAT).. Yankee Stadium has the 7th-lowest average fence height among all parks.. Hitting from the opposite that Drew Rasmussen throws from, Cody Bellinger will have an edge in today's game.
View 7 Picks

What Is An MLB Computer Pick?

MLB picks are bet suggestions based on our computer's assessment of the game. Tons of betting data goes into a computer pick, including pitching matchups, injury reports, analytics, and even recent betting trends.

How To Use MLB Computer Picks

You can use the tables above to help with your bets during the MLB season. The first section includes free, computer-generated picks for daily Major League Baseball games. Baseball bettors can choose to follow the computer, fade the computer, or simply use our computer picks as one element of their betting strategy.

This page also tees up access to deeper betting trends. For example, if a club's run line is favored, you can check their ATS trends, potentially opening up some quality underdog bets.

If you're ready to get started with MLB betting, visit our dedicated page highlighting the best MLB betting sites.

Moneyline

This is the most common and easiest wager for a bettor to make when it comes to MLB picks. Basically, to win an MLB moneyline pick, you just have to choose which team will win the game.

It's simple: if you bet the White Sox moneyline over the Red Sox and Chicago wins, you win your bet.

Run line

The run line is another name for a point spread that you may be more familiar with in NBA and NFL betting. A point spread varies in the NFL and NBA from as little as 0.5 points up to double-digit spreads. A baseball run line is almost always a 1.5-point spread.

The favorite will be -1.5 while the underdog will be +1.5. At the end of the game, if you take away 1.5 runs from the favorite or add 1.5 runs to the underdog and they end up winning the game, you win your MLB pick against the spread.

Totals (Over/Under)

Another common wager is to bet on the total in baseball, which is a bet on the total runs scored in the baseball game. You are simply choosing whether the final score will be Over or Under that total. Betting the Over/Under on a matchup is a great way to get started in MLB score predictions.

Free Computer Picks by Odds Shark

More MLB Picks & Betting Tools

NRFI/YRFI MLB Picks

A new and emerging MLB betting market is the NRFI/YRFI bet. These are quick-hitters in which you make a wager on the O/U total of the first inning, typically set at 0.5 runs. Thus, the bet is coined as No Run First Inning or Yes Run First Inning. No need to wait a couple of hours to cash a bet when it could be done in 20 minutes or less.

First Five Innings MLB Picks

The above options, moneyline, run line, and Over/Under, can also be placed on the first five innings of a game rather than the full game. Many experienced bettors will use this approach because, typically, this will take bullpens out of the equation and make your job researching the game easier. After all, you can just focus on the starting pitchers.

MLB Picks And Parlays

If you want to combine multiple games into one mega wager, you may consider making a parlay bet. A parlay is when you pick two or more MLB games on one single betting ticket, which will increase the payout of your bet.

But it also comes with more risk, as each of those MLB picks must hit for your ticket to pay out. Our parlay calculator is a great tool to find out what your potential payout would be.

If you're looking for more MLB picks content, check out our consensus picks and prop bets pages to get your fix. While you're at it, head over to our MLB promos page to get the best bang for your buck.

MLB Player Props

Player props are a great way to hone in on an individual matchup for a game. These types of wagers will be individualized for a player: Will Shohei Ohtani hit a home run? Will Gerrit Cole get seven strikeouts? Will Paul Skenes allow two earned runs?

You simply choose whether this outcome will happen or not. Keeping up to date on daily pitching matchups and batters on a hot streak can give you a huge boost when placing player prop bets.

MLB Futures Picks

Lastly, prior to the season and even throughout the season, you can place futures bets on all the long-term awards and outcomes. You can lock in an MLB pick on who will win their division, which squad will win the World Series, or even who will win the Rookie of the Year, MVP, or Cy Young.

MLB Free Picks FAQs

When do we release our MLB picks?

Covers’ MLB picks release on game day. Some significant matchups like playoff games release in the days leading up to the game.

What kinds of MLB picks do we make?

Covers provides free MLB picks covering many markets, including run lines, totals, moneylines, player props, and more.