MLS Predictions: Moneyline Picks for Every Matchday 12 Game

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst 13+ years betting experience
Updated: May 9, 2026 , 08:03 AM ET • 4 min read

Matchday 12 is loaded with value across the MLS board, from road underdogs and draw spots to home favorites in strong form. Here are our best MLS predictions and moneyline picks for every game this weekend.

Seattle Sounders FC midfielder Paul Arriola (17) kicks the ball.
Photo By - Reuters Connect. Seattle Sounders FC midfielder Paul Arriola (17) kicks the ball.

We’re entering the final stretch of the MLS campaign before the World Cup break, and Week 12 provides us with a blockbuster on Saturday night when the San Jose Earthquakes host the Vancouver Whitecaps. 

We didn’t have the greatest showing last week, but we nailed a tremendous upset as DC United pulled off the +360 win on the road at New York City FC.

Our MLS moneyline picks and free betting picks for Week 12 go over all the action, including a rivalry match between the New England Revolution and Philadelphia Union.

Jason Ence's 2026 Transparency Record
  • Matchday 11 results: 4-10, -3.96 units
  • MLS season: 69-88, -4.71 units

MLS moneyline picks for Matchday 12

Game Pick
Toronto FC Toronto FC vs Inter Miami FC Inter Miami Draw +280
Chicago Fire Chicago Fire vs New York Red Bulls New York Red Bulls Chicago Fire -172
CF Montreal CF Montreal vs Orlando City SC Orlando City SC Draw +290
New England Revolution New England Revolution vs Philadelphia Union Philadelphia Union New England Revolution +165
Charlotte FC Charlotte FC vs FC Cincinnati FC Cincinnati FC Cincinnati +200
Atlanta United Atlanta United FC vs LA Galaxy LA Galaxy Draw +250
FC Dallas FC Dallas vs Real Salt Lake Real Salt Lake FC Dallas +120
Nashville SC Nashville SC vs D.C. United D.C. United Draw +310
Colorado RapidsColorado Rapids vs St. Louis City SC St. Louis City SC Colorado Rapids +100
Seattle Sounders FC Seattle Sounders vs San Diego FC logo San Diego Seattle Sounders FC -133
San Jose Earthquakes San Jose Earthquakes vs Vancouver Whitecaps FC Vancouver Whitecaps Draw +260
Portland Timbers Portland Timbers vs Sporting Kansas City Sporting KC Portland Timbers -189
New York City FC New York City FC vs Columbus Crew SC Columbus Crew Columbus Crew SC +165
Minnesota United FC Minnesota United FC vs Austin FC Austin FC Minnesota United FC -143
Los Angeles FC Los Angeles FC vs Houston Dynamo Houston Dynamo Draw +300

Odds courtesy of Sports Interaction.

Enjoying Covers content? Add us as a preferred source on your Google account Add as a preferred source on Google

Toronto FC Toronto FC vs Inter Miami FC Inter Miami

Pick: Draw (+280)

There’s something very wrong with this Inter Miami team, and its capitulation from 3-0 up against Orlando City last week only further cemented that fact. Miami has yet to figure out how to replace Sergio Busquets in midfield, and its back line remains atrocious. Toronto isn’t figuring out how to win games, but it does know how to capture a point — and I’ll back TFC to do so again here.

Chicago Fire Chicago Fire vs New York Red Bulls New York Red Bulls

Pick: Chicago Fire (-172)

The Red Bulls have allowed the third-most set-piece goals in the league, and only Orlando has conceded more goals overall so far. The Fire have allowed just 11 goals through 10 matches, with an opponent conversion rate of 9.09% that ranks seventh-best in MLS. This juice is justified.

CF Montreal CF Montreal vs Orlando City SC Orlando City SC

Pick: Draw (+290)

Orlando was never supposed to be as bad as it looked to start the season, and Martin Ojeda reminded everyone last week that he’s a lethal scorer. The Lions are flying high after their comeback win over Miami, and these are the two worst defenses in the league in terms of allowing more goals than expected. This should be an entertaining stalemate.

New England Revolution New England Revolution vs Philadelphia Union Philadelphia Union

Pick: New England Revolution (+165)

The Revs have quietly moved into second place in the Eastern Conference behind Nashville, scoring nearly six more goals than expected. They’ve taken 16 of a possible 18 points from their last six league matches, while the Union have won once all season and have failed to score in three of their last four. I like New England to sneak out a 1-0 win.

Charlotte FC Charlotte FC vs FC Cincinnati FC Cincinnati

Pick: FC Cincinnati (+200)

After a solid start, Charlotte’s offense has sputtered. It has lost four straight in all competitions, failed to score in its last two, and dropped four of five in MLS play. Cincinnati is unbeaten in five and has scored 11 goals over its last four matches. Charlotte should look better back at home, but Cincinnati is the better team right now, and I love the price.

Atlanta United Atlanta United FC vs LA Galaxy LA Galaxy

Pick: Draw (+250)

Atlanta has rolled off three straight wins and looks to have finally found its best lineup. The Galaxy are the better team, but they’ve also picked up just one victory in their last 23 regular-season MLS road matches. I’ll back the Five Stripes to do enough to get a point.

FC Dallas FC Dallas vs Real Salt Lake Real Salt Lake

Pick: FC Dallas (+120)

Petar Musa has scored in six of his last seven starts for Dallas, and this is a different team with him on the pitch. He’s a key reason Dallas has scored four more goals than expected, and he should cause problems for a young RSL side that hasn’t been great on the road and is underperforming in front of goal.

Nashville SC Nashville SC vs D.C. United D.C. United

Pick: Draw (+310)

This may be the hardest match of the weekend to handicap. Nashville returns home from a trip to Tigres exhausted and banged up, with Sam Surridge and Patrick Yazbek expected to miss out. D.C. United is unbeaten in four league matches and presents value to grab a draw here in what could be a scoreless affair.

Colorado Rapids Colorado Rapids vs St. Louis City SC St. Louis City SC

Pick: Colorado Rapids (+100)

Colorado will be happy to return home for the first time in a month after claiming just four points from seven road outings. There’s no better way to get back into the win column than hosting a St. Louis City side that has scored just three goals in six away matches and is converting on just 6.38% of its shots this season.

Seattle Sounders FC Seattle Sounders vs San Diego FC logo San Diego FC

Pick: Seattle Sounders (-133)

San Diego is in absolute freefall, with just three points from its last eight MLS matches after a strong start to the campaign. Seattle has won all three of its home matches while outscoring opponents 8-2, and it’s allowing the lowest xG per shot of any team in the league. This should be an easy win.

San Jose Earthquakes San Jose Earthquakes vs Vancouver Whitecaps FC Vancouver Whitecaps

Pick: Draw (+260)

These may be the two best teams in MLS. Both rank Top 6 in opponent conversion rate and xG allowed per shot, and they’re tied atop the league with 26 goals scored. Both teams defend with all 11 players, are evenly matched, and will be without a key player — which makes the draw a strong value play.

Portland Timbers Portland Timbers vs Sporting Kansas City Sporting KC

Pick: Portland Timbers (-189)

If Portland were playing almost anybody else, there’s no way I’d back it at this kind of price. But this Sporting KC side is historically bad, with just 7.01 xG through 10 matches. Its 69 total shots make it the only team with fewer than 100 this season. The Timbers should get the victory in just their fifth home match of the year.

New York City FC New York City FC vs Columbus Crew SC Columbus Crew

Pick: Columbus Crew (+165)

NYCFC has two wins in its last nine matches in all competitions — and both came in the U.S. Open Cup. Columbus allows the sixth-fewest shots on target per 90 minutes, and NYCFC has been held scoreless in its last two matches. Columbus is one of my favorite road underdogs of the week.

Minnesota United FC Minnesota United FC vs Austin FC Austin FC

Pick: Minnesota United (-143)

Minnesota is in terrific form and now hosts an Austin side that has taken just two points from five road matches. Even more concerning, Austin has allowed 15 goals across those five road trips. The Loons have allowed one goal in four home fixtures. Take Minnesota to win its sixth match in seven league outings.

Los Angeles FC Los Angeles FC vs Houston Dynamo Houston Dynamo

Pick: Draw (+300)

Earlier this season, Houston couldn’t stop a sneeze. Now it has kept a clean sheet in three of its last four league matches. LAFC got dog-walked by Toluca in extreme altitude on Wednesday night and will be without Denis Bouanga due to suspension. This is a great spot for Houston to make a statement, and I think LAFC is overpriced.

Pages related to this topic

Jason Ence - Covers
Betting Analyst

Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

Popular Content

Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo Evalon Logo