MLS Predictions: Moneyline Picks for Every Matchday 10 Game

Jason Ence - Contributor at Covers.com
Jason Ence • Betting Analyst 13+ years betting experience
Updated: Apr 25, 2026 , 01:17 PM ET • 4 min read

Find out why Jason Ence is putting two units on the San Jose Earthquakes in Matchday 10 action, and much more.

San Jose Earthquakes MLS Daniel Munie
Photo By - Reuters Connect. San Jose Earthquakes defender Daniel Munie.

Matchday 9 of the Major League Soccer season came on a short week, and it provided plenty of drama on Wednesday night with multiple high-scoring affairs.

My MLS moneyline picks now turn to Matchday 10, where some teams will be playing their third match inside a week, while others are coming in off some much-needed rest. That has led to some very juicy favorites for this weekend’s slate.

My free betting picks break down which teams should win on Matchday 10.

Jason Ence's 2026 Transparency Record
  • Matchday 9 results: 3-8, -2.99 units
  • MLS season: 59-70, +0.69 units

MLS moneyline picks for Matchday 10

Game Pick
Toronto FC Toronto FC vs Atlanta United Atlanta United FC Toronto FC -108
CF Montreal CF Montreal vs New York City FC New York City FC DRAW +360
Minnesota United FC Minnesota United FC vs Los Angeles FC Los Angeles FC Minnesota United FC +145
Inter Miami FC Inter Miami vs New England Revolution New England Revolution Inter Miami FC -256
D.C. United D.C. United vs Orlando City SC Orlando City SC D.C. United -120
Columbus Crew SC Columbus Crew vs Philadelphia Union Philadelphia Union DRAW +260
FC Cincinnati FC Cincinnati vs New York Red Bulls New York Red Bulls DRAW +320
Cardinals St. Louis City SC vs San Jose Earthquakes San Jose Earthquakes San Jose Earthquakes +160
Nashville SC Nashville SC vs Cardinals Charlotte FC Nashville SC -154
Chicago Fire Chicago Fire vs Sporting Kansas City Sporting KC Chicago Fire -333
Austin FC Austin FC  vs Houston Dynamo Houston Dynamo FC Houston Dynamo +155
San Diego FC logo San Diego vs Portland Timbers Portland Timbers DRAW +310
Vancouver Whitecaps FC Vancouver Whitecaps vs Colorado Rapids Colorado Rapids Vancouver Whitecaps FC -270
Seattle Sounders FC Seattle Sounders vs FC Dallas FC Dallas Seattle Sounders FC -159
LA Galaxy LA Galaxy vs Real Salt Lake Real Salt Lake Real Salt Lake +187

Odds courtesy of Sports Interaction.

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Toronto FC Toronto FC vs Atlanta United Atlanta United FC

Pick: Toronto (-108)

The aforementioned drama was on full display in Toronto, when their GK Luka Gavran scored a header in the sixth minute of stoppage time to secure a draw against Philadelphia.

They’ve now drawn three in a row, but should get back to winning ways against an Atlanta side that has lost seven of its nine games and is traveling on short rest. 

CF Montreal CF Montreal vs New York City FC New York City FC

Pick: Draw (+360)

NYCFC shipped four goals in a draw with Cincy on Wednesday, and Montreal’s coming off rest and a 4-1 thumping of the Red Bulls. I can’t back them to get a victory here, but I think they’ll manage a result. 

Minnesota United FC Minnesota United FC vs Los Angeles FC Los Angeles FC

Pick: Minnesota (+145)

LAFC isn’t getting results right now, and a massive CONCACAF Champions Cup match with Toluca looms on the horizon. That means potential rotation for a Black and Gold side that hasn’t won in four, against a Minnesota side that has won four straight. I’ll take the value here with a Minnesota victory. 

Inter Miami FC Inter Miami vs New England Revolution New England Revolution

Pick: Inter Miami (-256)

Inter Miami is the first of our heavily-juiced picks that I cannot recommend actually playing, but I do expect them to win. The Revs are a terrible team on the road, and the Herons badly want to get that first home win in their new stadium.

Rodrigo De Paul looked tremendous on Wednesday in the win over Real Salt Lake, and that’s key for their success. 

D.C. United D.C. United vs Orlando City SC Orlando City SC

Pick: DC United (-120)

After scoring a combined 10 goals in 16 matches, DC United and Orlando City both exploded for four goals in their matches on Wednesday. Orlando picked up a victory while DC United drew, but I don’t expect that to translate to the road for the Lions—especially considering they’ve scored one goal in four away fixtures while conceding 17.

Back the home side here.  

Columbus Crew SC Columbus Crew vs Philadelphia Union Philadelphia Union

Pick: Draw (+260)

The Crew picked up an impressive 2-1 win over the Galaxy on Wednesday after scoring just one goal in their first three home fixtures. The Union are showing signs of life with a three-match unbeaten run.

The draw presents strong value given how inconsistent these sides have been. 

FC Cincinnati FC Cincinnati vs New York Red Bulls New York Red Bulls

Pick: Draw (+320)

FC Cincinnati are providing entertainment value, with their last seven matches featuring 42 goals. Granted, Cincy conceded 26 of those, but they managed two stoppage-time goals to get a 4-4 draw on Wednesday.

The Red Bulls are winless in their last three but have two draws, and I’ll back a similar result here as I cannot bet on Cincy at minus-odds. 

Cardinals St. Louis City SC vs San Jose Earthquakes San Jose Earthquakes

Pick: San Jose (+160)

I nearly tore my Achilles running to bet this one, and it’s a two-unit play for me.

Bruce Arena is working magic with this San Jose side, and they’re thriving at both ends. St. Louis has the advantage of a week’s worth of rest, but I doubt that will matter given how much they’re struggling to generate scoring chances. 

Nashville SC Nashville SC vs Cardinals Charlotte FC

Pick: Nashville (-154)

Charlotte’s second half capitulation to Orlando City was surprising, and it makes me wonder how they’ll respond. I do expect a little rotation given Tigres visits in CCC action on Tuesday, but a rotated Nashville beat Charlotte 2-1 just two weeks ago in the exact same situation.  

Chicago Fire Chicago Fire vs Sporting Kansas City Sporting KC

Pick: Chicago (-333)

This is another heavily-juiced pick that I wouldn’t play on its own. Both teams come in with a week of rest, and Chicago should lay waste to a Kansas City side that was outshot 27-2 by Vancouver last weekend.

Sporting has conceded at least three goals in five straight matches, including a defeat to USL Championship side Colorado Springs, while scoring just three total goals in that span. 

Austin FC Austin FC vs Houston Dynamo Houston Dynamo FC

Pick: Houston (+155)

Austin got housed in the second half at San Jose on Wednesday, and are now winless in eight matches in all competitions with three points from their last 21. The Dynamo have won two straight, and haven’t conceded a goal in either match. I love getting Houston at this price given the form of these teams. 

San Diego FC logo San Diego vs Portland Timbers Portland Timbers

Pick: Draw (+310)

And here I thought San Diego was done with the red cards. They’re not, picking up yet another in their fourth-straight defeat.

They created just one big chance against Houston despite having 72% possession. That said, I can’t back Portland to get a win on the road even with a week of rest.

I will back them to get their first away point though, especially at this price. 

Vancouver Whitecaps FC Vancouver Whitecaps vs Colorado Rapids Colorado Rapids

Pick: Vancouver (-270)

Both teams come in with a week of rest, which is why I think this could be one of the best matches of the weekend. I’m not at all a fan of this price for the Whitecaps, given how well Colorado have played this season. But the Rapids have lost three of their five on the road, and Vancouver’s only slip-up at home this season came to San Jose. 

Seattle Sounders FC Seattle Sounders vs FC Dallas FC Dallas

Pick: Sounders (-159)

The Sounders got a week off and welcome a Dallas side that is winless in three with two points in that span. Seattle has also won four straight at home against Dallas, and have lost 17 with four draws in their last 21 visits to Lumen Field.

The Sounders are the better team in better form and that rest will prove vitally important. 

LA Galaxy LA Galaxy vs Real Salt Lake Real Salt Lake

Pick: Real Salt Lake (+187)

The Galaxy showed just how desperately they need Joao Klauss in their loss at Columbus this week, creating just one big chance in the match. Their winless streak will run to four matches when they host Real Salt Lake, whose run of form has been quite impressive behind the play of Zavier Gozo and Diego Luna.

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Jason Ence - Covers
Betting Analyst

Jason has been hooked on football since watching Real Madrid and Manchester United in the 2003 Champions League, and has been betting on the sport for nearly 15 years. He has given soccer gambling and fantasy advice for nearly a decade, writing for sites including Rotowire, SB Nation, and The TwinSpires Edge.

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