Week 4 gets kickstarted with an all-NFC West showdown on Thursday Night Football as the Seattle Seahawks visit the Arizona Cardinals.
Both teams enter at 2-1, so the winner will be propelled to first place in the division. Before making your Seahawks vs. Cardinals predictions for this high-stakes contest on Thursday, September 25, consult our expert NFL picks!
Seahawks vs Cardinals TNF predictions
- Seahawks -1.5 (-110 at bet365)
- Under 43.5 (-110 at bet365)
- McBride anytime TD (+180 at bet365)
- Darnold o221.5 pass yds (-110 at bet365)
Seahawks vs Cardinals TNF best bets
Seahawks -1.5
Joe Osborne is all over the visiting Seattle Seahawks on Thursday night vs. the Arizona Cardinals, a team they've beaten seven straight times.
"I think Seattle is the more complete team, and I love the momentum they're riding off their last two blowout wins. Arizona will really feel the absence of James Conner as their offense is extremely light on weapons."
Under 43.5
Osborne sees this tilt falling below the listed total tonight.
"While Seattle’s defense has a very high ceiling, the Cardinals’ D has posted some respectable numbers. It’s fair to criticize Arizona’s competition, but all they can do is play the schedule that’s in front of them."
Seahawks vs Cardinals TNF TD picks
Trey McBride anytime TD
Rohit Ponnaiya sees the Cardinals continuing to use Trey McBride aggressively vs. a susceptible Seahawks defense.
"McBride leads the Arizona Cardinals in targets (24), receptions (17), and receiving yards (182). The Seattle Seahawks have struggled to defend tight ends, allowing a league-high 24 receptions and three touchdowns to the position thus far."
Seahawks vs Cardinals TNF props
Sam Darnold Over 221.5 passing yards
Ponnaiya tells you why Sam Darnold is poised to pile up the passing yardage tonight.
"Darnold is proving last year wasn't a fluke by leading the league in passing grade (91.4) per PFF. Last week, he threw for 218 yards despite attempting just 18 passes before sitting out the fourth quarter in a blowout win. I'm not sold on the Arizona Cardinals' defense, which faced Spencer Rattler in their season opener before benefitting from a banged-up 49ers offense led by a backup QB last week. Bryce Young threw for 328 yards against them in Week 2."
Seahawks vs Cardinals odds
Seahawks vs Cardinals game info
| Location: | State Farm Stadium, Glendale, AZ |
| Date: | Thursday, September 25, 2025 |
| Kickoff: | 8:15 p.m. ET |
| TV: | Amazon Prime |
Seahawks vs Cardinals latest injuries
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