Best Rams vs 49ers Same Game Parlay for Week 10

The Niners won't be able to contain Puka Nacua, but Jauan Jennings & Co. will be able to cover vs. the Rams on Sunday, per our SGP picks.

Neil Parker - Analyst at Covers.com
Neil Parker • Betting Analyst
Nov 6, 2025 • 13:19 ET • 4 min read
San Francisco 49ers NFL Jauan Jennings
Photo By - Imagn Images. San Francisco 49ers wide receiver Jauan Jennings in NFL action.

The underdog has championed this NFC West rivalry, and the Los Angeles Rams and San Francisco 49ers will meet for the second time this season at Levi’s Stadium on Sunday, November 9.

My Rams vs. 49ers same-game parlay and NFL picks are calling for San Fran to cover the number while wide receivers Jauan Jennings and Puka Nacua have big games in Week 10.

Our best Rams vs 49ers SGP for Week 10

The underdog has covered the spread in 13 of the past 14 games between the Los Angeles Rams and San Francisco 49ers, and I like the trend to continue with so much familiarity between the two teams on and off the field.

This spread is above the key numbers of 3 and 4, and the Niners could have No. 1 quarterback Brock Purdy (toe) back in action. 

Purdy returning would be a boon for San Fran wide receiver Jauan Jennings, too. Jennings has seen his yards per target drop to 6.2 after posting a 8.6 mark last year.

So, while the go-to receiver has been limited to 12 receptions for 117 yards on 19 targets the past three weeks, I’m expecting him to have an uptick in production Sunday.

The Niners are going to need to attack through the air to keep pace, and the Rams have allowed 12 wide receivers to rack up 46 or more receiving yards through eight games.

Turning to the final leg of this same-game parlay, Rams star Puka Nacua has topped 90 receiving yards in five of eight games, and even with a bye week and a missed game, he's still fourth in receiving yards (711) and tied for second in receptions (61) for the year.

The Pro Bowler is pacing the NFL in PFF receiving grade and sports an elite 83.6% catch rate while being targeted on 36.9% of his routes, too. 

San Francisco has also been beaten through the air this season with ranks of 26th in PFF coverage grade and 25th in pass defense DVOA while also allowing the eighth-highest EPA per dropback and catch percentage to opposing wide receivers.

Odds are correct at the time of publishing and are subject to change.
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Neil Parker - Covers
Betting Analyst

Neil Parker is, first and foremost, a sports fan. A huge supporter of the Cowboys, Cubs, and Maple Leafs, he has managed to parlay his passion into writing gigs at some of the top websites in the industry.

Neil takes a numbers-based approach to his handicapping and complements his in-depth statistical analysis with a keen eye on the markets to provide the best available odds. He loves to lean on his rolodex of idioms to offset his inner nerd. When it comes to wagering, he throws down on anything that catches his eye at bet365, Betway and BetVictor. He also keeps a close eye on CoolBet because the polar bear brand often has outlier NHL and NFL moneyline prices.

Neil graduated with honors from St. Thomas University in 2007 before completing his BEd at Acadia University in 2010. After teaching a myriad of courses and subjects, he found a groove delivering fun lessons to exceptional learners in non-traditional classroom environments. If his decade-plus teaching run taught him anything about sports betting, it’s to stay the course and use the summer – or offseason – to refresh and prepare to be better in the year to come.

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