Coming into Sunday’s game, both the Panthers and Patriots are at .333 with just a single victory each.
The Panthers had been awful through the opening two weeks of the season, but pulled off a huge shock beating the Falcons last Sunday, while the Patriots lost to the Steelers.
Our Panthers vs. Patriots predictions expect two poor teams to have a low-scoring game. Don’t miss our NFL picks, with the game kicking off at 1:00 pm at Gillette Stadium and available to watch on FOX.
Panthers vs Patriots prediction
Panthers vs Patriots Best bet: Under 43.5 (-115)
The Total Points line has dropped from 45.5 upon opening to 43.5, and it might yet still drop further. The odds movement is for good reason; these are two teams that have looked turgid offensively this season.
In terms of scoring, both teams have been very close in 2025, with Carolina just outscoring New England by 20.7 points per game to 20.
This game appears poised to be low-scoring, with the New England Patriots having the second-best record against the run in the NFL. That’s big news when Bryce Young has only thrown four touchdown passes through three games and failed to even throw one in their victory over the Falcons last Sunday.
The Carolina Panthers defense kept a shutout in that victory over the Falcons and has only given up 17.7 points per game, which puts them in a similar ballpark to some great defenses such as the Chargers and Texans.
Backing the Under looks the smartest play here. The Over is 1-2 through three games for the Patriots, 0-2 at Foxborough, and 0-1 when New England is the favorite.
Meanwhile, the Over is 1-2 in Panthers’ games. The Patriots have only scored more than 15 points once this season, while the Panthers have only managed it twice.
Don’t overthink it; these are two bad offenses with reasonable defenses.
Panthers vs Patriots same-game parlay
In addition to our best bet for Panthers vs Patriots we’re going to back Drake Maye to have Over 25.5 rushing yards. That’s a number that Maye has surpassed in two of three games this season and has averaged 4.1 yards per carry this season.
We’re also going to back TreVeyon Henderson to score his first NFL touchdown. Last week we saw him have the most touches of his NFL career, and it looks like it might be time for him to take over this Patriots backfield.
Panthers vs Patriots SGP
- Under 43.5
- Drake Maye Over 25.5 rushing yards
- TreVeyon Henderson anytime touchdown
Our big-ticket SGP: McMillan, Henderson Show Out
Our lottery same-game parlay is going big by adding two legs to our above SGP. We’re backing Tetairoa McMillan to have five or more receptions.
The wideout is questionable, but he’s likely to suit up and has had at least eight targets in every single game since being drafted this April.
For the final leg of the lottery SGP, we’re taking TreVeyon Henderson to have Over 17.5 receiving yards. Henderson has crushed that number in every game so far, and if he continues to get more touches, then it’s even more likely to land.
Panthers vs Patriots SGP
- Under 43.5
- Drake Maye Over 25.5 rushing yards
- TreVeyon Henderson anytime touchdown
- Tetairoa McMillan 5+ receptions
- TreVeyon Henderson Over 17.5 receiving yards
Panthers vs Patriots game predictions
Panthers vs Patriots moneyline prediction
The Patriots have given up the second-fewest rushing yards per game and should really limit Carolina's ability to score.
Panthers vs Patriots spread prediction
The Patriots covered the spread in their only other game following a loss.
Panthers vs Patriots Over/Under prediction
The Under has landed in both Patriots home games at Gillette Stadium this season.
Panthers vs Patriots odds
- Spread: Panthers +5.5 | Patriots -5.5
- Moneyline: Panthers +205 | Patriots -250
- Over/Under: Over 43.5 | Under 43.5
More NFL picks and odds from Covers
Panthers vs Patriots trend to know
The Panthers have cashed the second-quarter Over in 13 of their last 17 games. Find more NFL betting trends for Panthers vs. Patriots.
How to watch Panthers vs Patriots
| Location | Gillette Stadium, Foxborough, MA |
| Date | Sunday, September 21, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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