Kyler Murray's status for Week 6 against the Indianapolis Colts is no longer up in the air.
Cardinals QB Jacoby Brissett is expected to start Sunday in place of Kyler Murray, who is dealing with a foot injury, per me and @JFowlerESPN.
— Adam Schefter (@AdamSchefter) October 12, 2025
Brissett will make his first start for the Cardinals against the Colts, a team he played for from 2017-2020. pic.twitter.com/KWicOlo02D
The Arizona Cardinals franchise quarterback suffered a foot injury in last week's loss to the Titans. He briefly left the game after suffering the injury in the third quarter, but returned and finished up the contest.
However, his progress throughout the week hasn't been encouraging, and he was listed as questionable prior to being ruled out.
I break down how Murray's status is affecting the NFL odds for the Cardinals, and let you know how you should bet if backup Jacoby Brissett replaces him in the lineup.
Is Kyler Murray playing on Sunday?
No, Kyler Murray is not playing in today's game against the Indianapolis Colts. As a result, the line has moved from Colts -7 to Colts -9.5.
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Kyler Murray's season-to-date performance
Murray hasn't quite lived up to lofty expectations after being taken with the first pick in the 2019 draft.
That said, he's still a good starting QB who completed 68.3% of his passes for 962 yards with another 173 yards on the ground through five games this year. More importantly, he's gone 33-18-2 ATS (64.2% cover rate) as an underdog in his career.
Who do I bet on if Kyler Murray doesn't play?
There's obviously a drop-off from Murray to journeyman Jacoby Brissett. That said, Brissett is a capable veteran who has been in this spot many times in his career.
Over the last five years, Brissett started 21 games with Miami, Cleveland, and New England. His teams went 7-14 SU and 9-11-1 ATS in those 21 starts, and he averaged 209.2 passing yards per game.
If Murray is confirmed out before kickoff, we should see a drop in the receiving yards market for Marvin Harrison Jr., whose O/U is currently sitting at 50.5 yards.
That would be a good opportunity to back the Over on Harrison, since Brissett is a capable passer and is expected to play with a negative game script. Indy has also allowed the sixth-most receiving yards to wide receivers.
How to watch Cardinals vs Colts
| Location | Lucas Oil Stadium, Indianapolis, IN |
| Date | Sunday, October 12, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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