The Buffalo Bills will face the New York Jets for the final home game at Highmark Stadium on Sunday, January 4.
This AFC East matchup is a true mismatch, with New York being run over in four straight, and my top Jets vs. Bills predictions and NFL picks call for Buffalo to win convincingly in Week 18.
Jets vs Bills prediction
Jets vs Bills Best bet: Bills -7.5 (-115)
The Buffalo Bills land the perfect opponent to get back on track offensively and post a convincing Week 18 win in the final game at Highmark Stadium.
It’s been a bad season for the New York Jets, and it’s only gotten worse the past four weeks.
The Jets have dropped four straight by an average of 26.8 per game, and they’ve also failed to cover the spread in all four.
New York also ranks 31st in defensive DVOA while allowing the third-highest EPA and 38.3 points per game
With Buffalo No. 1 quarterback Josh Allen nursing a foot injury, the Bills could potentially turn to backup quarterback Mitchell Trubisky for the majority of this game, but I’m confident Trubisky can move the offense and score against this New York defense.
Additionally, Jets QB Brady Cook has been lost since taking over. He’s posted an NFL low EPA+CPOE composite while throwing for just 5.2 yards per attempt and a 58.8 completion percentage during the four-game losing streak.
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Jets vs Bills odds
- Spread: Jets +11.5 (-110) | Bills -11.5 (-110)
- Moneyline: Jets +450 | Bills -625
- Over/Under: Over 40.5 (-105) | Under 40.5 (-115)
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Jets vs Bills trend to know
The New York Jets have hit the Over in 14 of their last 20 games (+7.40 Units / 34% ROI). Find more NFL betting trends for Jets vs. Bills.
How to watch Jets vs Bills
| Location | Highmark Stadium, Orchard Park, NY |
| Date | Sunday, January 4, 2026 |
| Kickoff | 4:25 p.m. ET |
| TV | CBS |
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