The 11-4 Jacksonville Jaguars control their own destiny in the battle for the AFC South crown as they head to Lucas Oil Stadium to face the reeling 8-7 Indianapolis Colts today.
My Jaguars vs. Colts predictions and NFL picks expect Jacksonville to score at will against its division rival on Sunday, December 28. Don't miss kickoff at 1:00 p.m. ET on FOX.
Jaguars vs Colts prediction
Jaguars vs Colts Best bet: Jaguars team total Over 27.5 (-104)
These two met three weeks ago in Florida, with the Jacksonville Jaguars winning 36-19. That was the game in which Daniel Jones, who was already badly hurt, had his season ended. However, it was more the Indianapolis Colts' defense that led to the loss.
The Jaguars scored 28 points in the first half — 14 off two turnovers — and also had two long drives that resulted in touchdowns.
Since their bye week in Week 8, the Jags have averaged 33.0 points per game. That includes scoring 34 on the Broncos, 35 on the Chargers, and 29 on the Texans.
The Jaguars are 12-3 on their team total Over this year, the best record in the NFL in that category. They're especially good on the road, with a 7-0 record on the team total Over. A major reason has been Trevor Lawrence's play.
T-Law has 14 touchdowns and no picks in his last four games, and Jacksonville is 8-for-11 in converting red zone possessions into TDs in their previous two outings.
The Colts have allowed 48 and 36 points in two of their last three games, and the Jags have a ton to play for here.
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Jaguars vs Colts same-game parlay
Jakobi Meyers scored a touchdown in three straight games after getting into the Jags offense, including one against the Colts last time out.
Brenton Strange has at least three catches in four of five games, and Indianapolis has struggled with tight ends recently.
Jaguars vs Colts SGP
- Jaguars team total Over 27.5
- Jakobi Meyers anytime touchdown
- Brenton Strange Over 2.5 catches
Our big-ticket SGP: Taylor turned down
Jacksonville hasn't allowed a single player to reach 75 rushing yards all season, and Jonathan Taylor won't change that.
Jaguars vs Colts SGP
- Jaguars team total Over 27.5
- Jakobi Meyers anytime touchdown
- Brenton Strange Over 2.5 catches
- Jonathan Taylor Under 73.5 rushing yards
Jaguars vs Colts odds
- Spread: Jaguars -5.5 (-118) | Colts +5.5 (-104)
- Moneyline: Jaguars -270 | Colts +220
- Over/Under: Over 48.5 (-108) | Under 48.5 (-112)
Jaguars vs Colts game predictions
Jaguars vs Colts moneyline prediction
The Jaguars need a win to stay alive for the No. 1 seed in the AFC, and they'll get it.
Jaguars vs Colts spread prediction
Since 2015, the Jaguars are 17-3-1 against the spread against the Colts, and 7-2-1 ATS in Indianapolis. Back the trends.
Jaguars vs Colts Over/Under prediction
These two teams combined for 55 points in their last matchup, and the Jags' offense has been on fire in recent weeks. Take the Over.
More NFL picks and odds from Covers
Jaguars vs Colts trend to know
The Jacksonville Jaguars have hit the team total Over in 15 of their last 20 games. Find more NFL betting trends for Jaguars vs. Colts.
How to watch Jaguars vs Colts
| Location | Lucas Oil Stadium, Indianapolis, IN |
| Date | Sunday, December 28, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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