The 7-1 Indianapolis Colts keep rolling and now face a reeling defense on Sunday when they travel to the Steel City to take on the 4-3 Pittsburgh Steelers.
It will be tough for the Steelers to stop this balanced Colts offense, and there is one specific matchup that we need to capitalize on.
Find out who I like in my Colts vs. Steelers predictions and NFL picks for November 2.
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Colts vs Steelers prediction
Colts vs Steelers Best bet: Jonathan Taylor Over 93.5 rushing yards (-114)
Indianapolis Colts running back Jonathan Taylor is coming off yet another monster game with 153 yards rushing and two touchdowns.
That was his fourth game this season of at least 100 yards, and he is now averaging 106.3 yards per game on the ground and an astounding 5.9 yards per carry.
The Pittsburgh Steelers have already allowed three different running backs to hit the century mark on the ground this season.
Those three running backs were Breece Hall, Kenneth Walker, and Chase Brown. All solid young running backs, but nothing like the talent of Taylor.
T.J. Watt has aligned on the left edge, which is the offensive right, on 94.1% of his snaps this season.
The Steelers have allowed just 3.9 yards per carry and -27 rushing yards over expected on runs to the right, but 4.7 yards per carry and a 14.4% explosive run rate on runs to the left.
Meanwhile, Taylor has averaged 6.7 yards per carry on designed runs to the left this season, with 17 of his 23 explosive runs coming in that direction.
It will just be another day at the office for Taylor against this Steelers defense, and I expect another century mark on the ground for the MVP candidate.
Colts vs Steelers same-game parlay
To add to my best bet, I am going to add the Over, as the Colts' offense is the best in the NFL, and the Steelers will be able to hit some deep shots with Aaron Rodgers to score themselves.
Finally, I am taking Tyler Warren to hit his receiving total after the Steelers just got destroyed by Tucker Kraft in yards after the catch.
Colts vs Steelers SGP
- Jonathan Taylor Over 93.5 rushing yards
- Tyler Warren Over 55.5 receiving yards
- Over 50.5
Our big-ticket SGP: DK to the House!
D.K. Metcalf has a touchdown in five of his last six games and will be able to connect on deep passes against this Colts secondary.
Colts vs Steelers SGP
- Jonathan Taylor Over 93.5 rushing yards
- Tyler Warren Over 55.5 receiving yards
- Over 50.5
- DK Metcalf anytime touchdown
Colts vs Steelers odds
- Spread: Colts -2.5 (-120) | Steelers +2.5 (+100)
- Moneyline: Colts -150 | Steelers +125
- Over/Under: Over 48.5 (-110) | Under 48.5 (-110)
More NFL picks and odds from Covers
Colts vs Steelers trend to know
The Indianapolis Colts have hit the Game Total Over in 14 of their last 20 games. Find more NFL betting trends for Colts vs. Steelers.
How to watch Colts vs Steelers
| Location | Acrisure Stadium, Pittsburgh, PA |
| Date | Sunday, November 2, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | CBS |
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