Christian McCaffrey Picks, Predictions & Best Bets for Rams vs 49ers

Christian McCaffrey has fully rebounded from an earlier-season injury, and that's bad news for the Los Angeles Rams.

Sam Farley - Contributor at Covers.com
Sam Farley • Betting Analyst
Nov 8, 2025 • 10:48 ET • 4 min read
Christian McCaffrey of the San Francisco 49ers
Photo By - Imagn Images. Christian McCaffrey of the San Francisco 49ers.

This Sunday, we have a massive NFC West matchup with the Los Angeles Rams visiting the San Francisco 49ers, and both teams are tied with six wins.

I’ve taken a long look at the Christian McCaffreys odds to find the very best ways for you to get involved with the 49ers running back on Sunday.

Read more in my NFL picks for November 9. 

Christian McCaffrey prop pick

Christian McCaffrey best bet:  Christian McCaffrey Over 5.5 receptions (-132 at FanDuel)

This Sunday’s crunch divisional game between the Los Angeles Rams and San Francisco 49ers is likely going to be decided by how often their teams get the ball in the hands of their star players, Puka Nacua and Christian McCaffrey

It’s been a return to form for McCaffrey, who struggled with injury, but he’s now back to his best. He only ranks ninth in the NFL’s rushing yard table but also sits seventh in recent yards, with 626 receiving yards, over 150 yards ahead of the next closest running back in that table.

McCaffrey is a volume monster and ranks third in the NFL for targets, with 80 across the Niners’ games this season. In terms of his line for this game it stands at 5.5 receptions, that’s a number he hasn’t hit in his past two games, although he did have enough targets to make that number.

However, his first seven games of the season he managed to cover that line.

The Rams are giving up an average of 4.1 receptions per game to running backs this season. That’s two catches under CMC’s line but given how often the team target him, they should give him enough opportunity to cover this with ease.

Christian McCaffrey same-game parlay

Christian McCaffrey Over 5.5 receptions

Christian McCaffrey first touchdown

Christian McCaffrey 40+ receiving yards

Get +722 on this Christian McCaffrey Same-Game Parlay. We’re tripling up on CMC with three legs based on the Niners’ RB. Next up is backing him to open the scoring in the game. 

He’s opened up the scoring in two of nine games this season and is the primary offensive weapon for the Niners inside the red zone.

Finally, we’re going to take a slightly lower alternate line on McCaffrey’s receiving yard line with 40+.

We’re taking this number to go somewhat more conservative, and he’s exceeded 40 receiving yards in every single one of his games this season.

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Sam Farley
Betting Analyst

Sam is based in the United Kingdom, where he grew up living and breathing soccer, before discovering - and playing - a different kind of football at the University of Bristol. He’s worked in the media covering soccer and the NFL for the better part of a decade, and has been a regular on the Matchbook NFL Podcast. His work has also appeared in a wide range of publications including The Telegraph, The Independent, VICE, and MSN.

The search for great betting value is a daily one, and Sam always hunts out big prices with a particular focus on player props. Sam’s best advice for bettors is to track their bets on a spreadsheet, that way you can keep an eye on your P&L but also the types of bets and sports that you are most successful in. He also recommends using a variety of different sportsbooks, with bet365, Betfair and Paddy Power amongst his favorites.

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