An already eliminated and Patrick Mahomes-less Kansas City Chiefs squad heads to Nashville this afternoon to take on the Tennessee Titans at Nissan Stadium.
Kansas City’s defense is still solid, and my Chiefs vs. Titans predictions and NFL picks expect it to keep Cam Ward contained.
Chiefs vs Titans prediction
Chiefs vs Titans Best bet: Cam Ward Under 179.5 passing yards (-114)
Cam Ward has definitely had his road bumps in Year 1 after going No. 1 overall in April’s NFL Draft.
The Miami product has thrown for just 2,638 yards and 11 touchdowns against seven interceptions. Playing for a struggling franchise like the Tennessee Titans hasn’t been easy.
The quarterback has cashed the Under in passing yards in three straight appearances, finishing with 170 yards through the air last weekend in a loss to the San Francisco 49ers.
While the Kansas City Chiefs may be missing the playoffs, they’re still fifth in fewest total yards allowed, and Andy Reid’s pass defense is also 13th in fewest yards allowed through the air.
Ward doesn’t have a lot of weapons to work with, and he hasn’t cashed the Over since late November. The Chiefs are still motivated to finish the campaign on a high note, and I believe they will keep Ward under wraps in Week 16.
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Chiefs vs Titans same-game parlay
Travis Kelce has had a couple of crucial drops this season, but he’s still one of the Chiefs’ top pass-catchers, reeling in 67 receptions for 797 yards and five touchdowns. Kelce has cashed the Over in receiving yards in six of his last eight, and two of his last three.
Kareem Hunt has proven to be reliable this year at running back for K.C., but after a quiet performance in Week 15, his total is incredibly low here.
Hunt was limited to only six carries for 12 yards, but before that, he hit the Over in rushing yards in six straight games, running for at least 30 yards in each of those contests.
Chiefs vs Titans SGP
- Cam Ward Under 179.5 passing yards
- Travis Kelce Over 43.5 receiving yards
- Kareem Hunt Over 27.5 rushing yards
Our big-ticket SGP: Kelce finds paydirt
Kelce has just one touchdown in his last three games, but four of his five scores this season have come on the road.
Chiefs vs Titans SGP
- Cam Ward Under 179.5 passing yards
- Travis Kelce Over 43.5 receiving yards
- Kareem Hunt Over 27.5 rushing yards
- Travis Kelce anytime touchdown
Chiefs vs Titans game predictions
Chiefs vs Titans moneyline prediction
Without Mahomes, the Chiefs are just -168 moneyline favorites in today's game. Those odds would definitely be different if their QB1 were under center, but regardless, I do believe KC will win. Gardner Minshew is an experienced figure, and even with Mahomes sidelined, the Chiefs are a far better team than the Titans.
Chiefs vs Titans spread prediction
The spread is set at just a field goal, but the Chiefs should have no problems covering. Minshew has no shortage of weapons at his disposal, and Tennessee poses little threat on both sides of the ball. They’re one of the worst teams in the NFL, and they’re 0-7 at home.
Chiefs vs Titans Over/Under prediction
The total is set at just 37.5 points, which is quite low. It’s understandable, though. KC isn’t the same beast without Mahomes, and the Titans struggle immensely to score points. The Chiefs have hit the Under in back-to-back games, and Tennessee’s offense will have trouble mustering up offense against a stout KC defense. The visitors either blow the Titans out, or it’s a low-scoring game.
Chiefs vs Titans odds
- Spread: Chiefs -3 | Titans +3
- Moneyline: Chiefs -168 | Titans +142
- Over/Under: Over 37.5 | Under 37.5
More NFL picks and odds from Covers
Chiefs vs Titans trend to know
The Titans have only cashed the moneyline in four of their last 20 games for -10.42 units and a -46% ROI. Find more NFL betting trends for Chiefs vs. Titans.
How to watch Chiefs vs Titans
| Location | Nissan Stadium, Nashville, TN |
| Date | Sunday, December 21, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | CBS |
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