Week 9 comes to a close on Monday Night Football when the Arizona Cardinals head East to take on the Dallas Cowboys.
Our Cardinals vs. Cowboys predictions have you covered with everything from a spread pick to props for this November 3 matchup.
Cardinals vs Cowboys MNF predictions
- Cowboys -3 (-110 at bet365)
- Over 54 (-110 at bet365)
- Pickens anytime TD (+135 at bet365)
- Brissett Over 0.5 interceptions (+105 at bet365)
Cardinals vs Cowboys MNF best bets
Cowboys -3
With Kyler Murray out for another week, Josh Inglis thinks the Cowboys have a better chance at winning big.
"I think in the range of outcomes, Dallas can win big in this game while the Cards cannot. Brissett was a 10-point dog at the Colts three weeks ago for a reference."
Over 54
Despite such a big number, all signs point to these teams eclipsing the Over.
"Combined, these teams are 10-5 O/U with the Cowboys making up the most of the Overs with a 6-2 O/U record, which is 3-0 O/U at home with games of 66, 80, and 77 points. It's a big number that opened at 51.5 last Sunday."
Cardinals vs Cowboys MNF TD picks
George Pickens
Ceedee Lamb is the WR1 for Dallas, but Kenny Ducey is eyeing George Pickens to find paydirt instead.
"Only five players in football have more red zone targets than George Pickens, who has 12, and three of his four red zone catches have gone for six. With some names at linebacker banged up for Arizona to boot, this has to be the way to go."
Cardinals vs Cowboys MNF props
Jacoby Brissett Over 0.5 interceptions
Jason Logan doesn't think Jacoby Brissett is going to get out of Jerry's World unscathed.
"With Arizona pegged as a road underdog and the total among the highest on the board, Brissett could be forced to pass more and make tough throws to keep the chains moving. Dallas hasn’t been as dangerous in terms of takeaways as year’s past, but it does have four INTs on the season. Player models range from 0.6 interceptions to as high as 1.6 INTs."
Cardinals vs Cowboys odds
Cardinals vs Cowboys game info
| Location: | AT&T Stadium, Arlington, TX |
| Date: | Monday, November 3, 2025 |
| Kickoff: | 8:15 p.m. ET |
| TV: | ESPN |
Cardinals vs Cowboys latest injuries
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