Two AFC squads that are struggling more than expected this season collide on Thursday Night Football as the Buffalo Bills visit the Houston Texans.
Both teams could use a win to stay afloat in their respective divisions. Our NFL experts present their best Bills vs. Texans predictions for this pivotal Week 12 lid-lifter.
Bills vs Texans TNF predictions
- Texans +6 (-110 at bet365)
- Under 43.5 (-110 at bet365)
- Marks anytime TD (+125 at bet365)
- Allen o33.5 rush yds (-110 at bet365)
Bills vs Texans TNF best bets
Texans +6
Joe Osborne expects the Houston Texans to hang tough with the Buffalo Bills on TNF.
"This is too many points to give a home team with a great defense. The Bills have been shaky on the road with outright losses in Miami and Atlanta, and now they’re on a short-week trip against a team that’s quietly won three of its last four."
Under 43.5
Osborne expects the Texans' defense to hold the line en route to a low-scoring tilt.
"I love the Under in this game. Thanks to an elite defense and poor play on the offensive side of the ball, Houston’s games are averaging just 38.3 combined points."
Bills vs Texans TNF TD picks
Woody Marks anytime TD
Kyle LaRusic sees the Woody Marks TD prop as the best value on the board based on the Bills' struggles vs. tailbacks in 2025.
"Buffalo has been getting eaten alive in the trenches, surrendering over 120 yards per game on the ground against RBs. Those RBs have been finding success in the red zone, too, with 14 rushing scores against the Bills."
LaRusic also cites Marks' increased workload of late.
"Marks has been fighting for RB1 with Nick Chubb over the last several weeks, with both backs rushing 99 times each. However, it seems the Texans' coaching staff has finally given in, with Woody having 32 rushes to Chubb's eight over the past two outings."
Bills vs Texans TNF props
Josh Allen Over 33.5 rushing yards
Rohit Ponnaiya sees Josh Allen using his legs early and often on TNF.
"Houston is 18th in the league in rushing yards allowed per game to opposing QBs while ranking dead-last in yards allowed per scramble (10.7). That's bad news against Buffalo Bills pivot Josh Allen, who is big, fast, and more than willing to pick up tough yards on the ground. The reigning NFL MVP is second among all QBs with 351 rushing yards this season."
Bills vs Texans odds
Bills vs Texans game info
| Location | NRG Stadium, Houston, TX |
| Date | Thursday, November 20, 2025 |
| Kickoff | 8:15 p.m. ET |
| TV | Amazon Prime |
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