We’ve got a compelling C-USA showdown on Tuesday night as the Western Kentucky Hilltoppers travel to face the Louisiana Tech Bulldogs.
The road team has won and covered the spread in each of the last four meetings, and my Western Kentucky vs. Louisiana Tech predictions are leaning toward that trend continuing in this crucial matchup.
Read on for my college football picks for Tuesday, October 21.
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Western Kentucky vs Louisiana Tech prediction
Western Kentucky vs Louisiana Tech best bet: Western Kentucky +3.5 (-108)
The Western Kentucky Hilltoppers can cover the spread because they can both score on the Louisiana Tech Bulldogs and slow their offense enough to keep this close.
Offensively, Maverick McIvor (1,863 yards, 12 TDs) and a backfield by committee force defenses to account for the entire field.
McIvor’s accuracy and WKU’s third-down prowess will sustain drives and create red-zone chances against a Tech unit that leans on volume rushing.
Special teams help, too, and Cole Maynard’s booming punts will force the Bulldogs into less-than-desirable field position for most of the night.
Defensively, WKU is stout on key downs (allowing just 35.1% on third downs), creates takeaways (1.2 per game), and generates enough pressure to disrupt long Tech possessions.
Add the wrinkle that Louisiana Tech’s QB Blake Baker is listed day-to-day (possible out/limited), and the Bulldogs’ offensive ceiling drops further.
Between offensive efficiency, a bend-but-don’t-break defense, special teams, and the key number cushion, WKU should cover +3.5.
Western Kentucky vs Louisiana Tech same-game parlay
McIvor has only cleared his passing prop number once, but he faces a Bulldogs secondary allowing 269.5 passing yards per game.
I’ll add the Under to the third leg as three of their last four meetings have gone Under the game total.
Western Kentucky vs Louisiana Tech SGP
- Western Kentucky +3.5
- Maverick McIvor Over 259.5 passing yards
- Under 50.5
Our deep-ball SGP: Henry, Hutchinson Run Up the Yards
Hilltoppers wideout Matthew Henry has cleared his receiving yards prop in three straight games.
K.D. Hutchinson leads WKU in receptions and has cleared his receiving props number twice this season.
Western Kentucky vs Louisiana Tech SGP
- Western Kentucky +3.5
- Maverick McIvor Over 259.5 passing yards
- Under 50.5
- K.D. Hutchinson Over 45.5 receiving yards
- Matthew Henry Over 52.5 receiving yards
Western Kentucky vs Louisiana Tech game predictions
Western Kentucky vs Louisiana Tech moneyline prediction
The visiting side has won each of the last four meetings between these schools. With Baker possibly out or restricted, I would lean toward Western Kentucky to win outright.
Western Kentucky vs Louisiana Tech spread prediction
As our best bet highlights, Western Kentucky is 5-2-0 against the spread and should cover.
Western Kentucky vs Louisiana Tech Over/Under prediction
This matchup has gone Under the game total in three of the last four. I’m expecting a fierce defensive battle, and believe tonight’s C-USA clash ends Under the total.
Western Kentucky vs Louisiana Tech odds
- Spread: Western Kentucky +3.5 (-108) | Louisiana Tech -3.5 (-112)
- Moneyline: Western Kentucky +138 | Louisiana Tech -164
- Over/Under: Over 50.5 (-110) | Under 50.5 (-110)
Western Kentucky vs Louisiana Tech trend to know
The visiting team has covered the spread in each of their last four meetings. Find more college football betting trends for Western Kentucky vs Louisiana Tech.
How to watch Western Kentucky vs Louisiana Tech
| Location | Joe Aillet Stadium, Ruston, LA |
| Date | Tuesday, October 21, 2025 |
| Kickoff | 7:30 p.m. ET |
| TV | CBSSN |
Western Kentucky vs Louisiana Tech latest injuries
Western Kentucky vs Louisiana Tech weather
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Odds are correct at the time of publishing and are subject to change.
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