Week 6 is when the 2025 college football season stops flirting with chaos and fully commits. Conference races tighten, unbeaten runs are tested in hostile stadiums, and Heisman campaigns either ignite or sputter. From early kickoffs to after-dark drama, every snap carries playoff weight and poll-shaping consequence.
It’s wall-to-wall action, and we’ve got ChatGPT in the war room.
The generative AI chatbot has crunched the odds, sized up the matchups, and is dropping fearless NCAAF picks and analysis for every Week 6 game featuring an AP Top 25 team.
Strap in. The fireworks are about to fly!
NCAAF Week 6 moneyline picks
| Matchup | Pick |
|---|---|
 West Virginia vs No. 23  BYU |
-1200 |
No. 14  Iowa State vs  Cincinnati |
-118 |
 Kentucky vs No. 12  Georgia |
-1800 |
 Wisconsin vs No. 20  Michigan |
-900 |
No. 22  Illinois vs  Purdue |
-375 |
No. 7  Penn State vs  UCLA |
-4000 |
No. 9  Texas vs  Florida |
-275 |
No. 16  Vanderbilt vs No. 10  Alabama |
-410 |
 Boise State vs No. 21  Notre Dame |
-1200 |
No. 24  Virginia vs  Louisville |
-250 |
 Kent State vs No. 5  Oklahoma |
NA |
No. 11  Texas Tech vs  Houston |
-450 |
 Minnesota vs No. 1  Ohio State |
-3500 |
No. 3  Miami vs No. 18  Florida State |
-192 |
 Mississippi State vs No. 6  Texas A&M |
-650 |
Odds courtesy of FanDuel.
No. 23 BYU vs West Virginia
Moneyline prediction: BYU (-1200)
Odds: BYU -19.5; total 47.5.
BYU lays a big number at home and the market tells the story. The Cougars’ defense has been steady enough to force long fields, and LaVell Edwards Stadium is a tough venue for a team that needs sustained drives. With a near three-touchdown spread, a straight-up pick points clearly to BYU.
No. 14 Iowa State at Cincinnati
Moneyline prediction: Cincinnati (-118)
Odds: Iowa State +1.5; total 53.5.
With a tight spread and near-pick’em prices, home-field often breaks the tie. Cincinnati’s number suggests marginal edges in situational play and special teams. Iowa State’s defense usually travels, but the market shade toward the Bearcats is enough for a straight-up nod to the home side.
No. 12 Georgia vs Kentucky
Moneyline prediction: Georgia (-1800)
Odds: Georgia -20.5; total 48.5.
This is classic “elite team at home vs. a scrappy underdog.” The two-plus-touchdown spread underscores the Bulldogs’ advantages on both lines and their ability to wear down Kentucky over four quarters. For a moneyline wager, Georgia is the sturdy anchor leg for parlays.
Wisconsin vs No. 20 Michigan
Moneyline prediction: Michigan (-900)
Odds: Michigan -16.5; total 42.5.
A low total paired with a two-score spread implies Michigan’s defense should dictate pace while the offense stacks patient scoring drives. Wisconsin’s path requires finishing red-zone trips and winning field position; that’s a tough ask in Ann Arbor. The moneyline choice is the Wolverines.
No. 22 Illinois vs Purdue
Moneyline prediction: Illinois (-375)
Odds: Illinois -9.5; total 57.5.
Laying double digits against a conference foe is rarely comfortable, but the moneyline price reflects a material gap. Illinois projects to control the line of scrimmage and shorten the game with methodical drives. Purdue can hang if it hits explosives, yet the safer straight-up side is the Illini at home.
No. 7 Penn State vs UCLA
Moneyline prediction: Penn State (-4000)
Odds: Penn State -25.5; total 50.5.
Penn State is laying -25.5 with a total of 50.5, indicating a massive power rating edge and an expectation the Nittany Lions control the game on both lines. With UCLA needing multiple high-leverage breaks to stay within striking distance, the straight-up play is Penn State.
No. 9 Texas vs Florida
Moneyline prediction: Texas (-275)
Odds: Texas -6.5; total 41.5.
A one-score spread on the road signals respect for the Gators’ environment, but Texas is priced as the better roster. In a lower-total game, one or two high-leverage plays can swing it; the market leans Longhorns to make them. Texas moneyline is the call.
No. 16 Vanderbilt vs No. 10 Alabama
Moneyline prediction: Alabama (-410)
Odds: Alabama -10.5; total 55.5.
The Tide are shorter favorites than usual, but the number still reflects a meaningful talent gap and Bryant-Denny advantage. Vanderbilt has improved, yet Alabama’s depth typically shows after halftime. For straight-up purposes, laying the juice on Alabama is the sensible choice.
Boise State vs No. 21 Notre Dame
Moneyline prediction: Notre Dame (-1200)
Odds: Notre Dame -20.5; total 63.5.
The Irish are heavy home favorites and should have edges in the trenches and depth across the skill positions. Boise State’s best route is a shootout, but that requires trading touchdowns consistently. The price is steep, yet for straight-up bettors, the safer pick is Notre Dame.
No. 24 Virginia vs Louisville
Moneyline prediction: Louisville (-250)
Odds: Virginia +6.5; total 62.5.
The Cardinals are favored over a ranked visitor, a sign the matchup and venue matter here. Louisville’s offense tends to spike at home, and the spread sits near a touchdown. Even with some volatility in a higher-total game, the moneyline edge belongs to the home team.
Kent State vs No. 5 Oklahoma
Moneyline prediction: Oklahoma
Odds: Oklahoma -45.5; total 53.5.
Oklahoma is a straight-up play because the market has them around a 45.5-point favorite, signaling a massive talent and depth edge that should show up in the trenches, on special teams, and over four quarters. Kent State would need multiple short fields and turnover luck to hang around, while the Sooners’ overall efficiency makes outright defeat highly unlikely.
No. 11 Texas Tech vs Houston
Moneyline prediction: Texas Tech (-450)
Odds: Texas Tech -11.5; total 50.5.
Double-digit road chalk is always a sweat, but the board suggests Tech has the more reliable offense and pass rush. Houston’s upset chances hinge on explosive plays and short fields; limit those, and the Red Raiders’ efficiency should carry them straight-up.
Minnesota vs No. 1 Ohio State
Moneyline prediction: Ohio State (-3500)
Odds: Ohio State -23.5; total 44.5.
A lowish total for such a big spread implies the Buckeyes can control this game without needing 50 points. Minnesota typically wants to grind clock, exactly what a superior favorite can live with. Straight-up, there’s no reason to overthink it: Ohio State.
No. 3 Miami vs No. 18 Florida State
Moneyline prediction: Miami (-192)
Odds: Miami -4.5; total 53.5.
Rivalry volatility is real, but the market’s slight lean to Miami reflects better down-to-down consistency to this point in the season. With a spread under a touchdown, moneyline protection against late-game chaos makes sense. The pick is the Hurricanes.
Mississippi State vs No. 6 Texas A&M
Moneyline prediction: Texas A&M (-650)
Odds: Texas A&M -14.5; total 55.5.
The Aggies are significant home favorites with the defensive front to disrupt Mississippi State’s rhythm. If A&M avoids giveaways, the pressure rate should tilt drive outcomes. Laying the moneyline juice is more conservative, but in a parlay it’s a logical piece.
ChatGPT has gone 80-16 so far this season for +56.7 units.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
