College Football Week 3 Picks: ChatGPT Predicts the Winner of Every Big Game

Indiana State vs No. 22 Indiana

Moneyline prediction: Indiana
Odds: Indiana -48.5; total 59.5.

FanDuel has the moneyline locked, but the spread tells the story. Indiana’s advantage in size, speed, and depth should be overwhelming from the opening kick. Upsets happen, but everything here leans heavily toward a comfortable home win. For moneyline purposes, the Hoosiers are the clear call.

No. 4 Oregon vs Northwestern

Moneyline prediction: Oregon (-7000)
Odds: Oregon -27.5; total 48.5.

Oregon looks every bit like a playoff contender, and Northwestern simply lacks the depth to hang for four quarters. Expect the Ducks to overwhelm early with speed and talent. This won’t be an upset spot — Oregon wins big at home.

No. 12 Clemson vs Georgia Tech

Moneyline prediction: Clemson (-172)
Odds: Clemson -3.5; total 53.5.

This is one of the tighter spreads among ranked matchups, but Clemson has the edge. Their defense remains strong, and if the offense can avoid costly turnovers, they should outlast Georgia Tech. This is closer than Tigers fans would like, but Clemson survives.

No. 13 Oklahoma vs Temple

Moneyline prediction: Oklahoma (-3000)
Odds: Oklahoma -21.5; total 51.5.

Temple’s defense has battled, but Oklahoma’s pace and playmaking usually create too many explosive chances over four quarters. The Sooners’ edge in the trenches and special teams should tilt field position and drives. This projects as a businesslike road win. Straight-up, Oklahoma is the side.

Wisconsin vs No. 19 Alabama

Moneyline prediction: Alabama (-2300)
Odds: Alabama -20.5; total 46.5.

Alabama has steadied itself after a shaky Week 1, and Wisconsin doesn’t look equipped to pull an upset on the road. The Tide’s defense should control the tempo, while the run game pounds away against a Badgers front that has struggled. This is Alabama’s game all the way.

Central Michigan vs No. 23 Michigan

Moneyline prediction: Michigan (-7000)
Odds: Michigan -27.5; total 41.5.

The Wolverines are heavy favorites for a reason. Central Michigan has no real answer for Michigan’s physicality in the trenches or the skill talent outside. It’s unlikely to be close, and the low total reflects Michigan’s defense setting the tone. Wolverines roll at home.

South Alabama vs No. 24 Auburn

Moneyline prediction: Auburn (-4000)
Odds: Auburn -24.5; total 54.5.

The Tigers are massive favorites at Jordan-Hare, and South Alabama’s defense has no clear path to slowing down Auburn’s ground game. Auburn’s offense should dominate time of possession, leading to a comfortable straight-up win.

No. 6 Georgia vs No. 15 Tennessee

Moneyline prediction: Georgia (-184)
Odds: Georgia -4.5; total 49.5.

FanDuel’s board shows Georgia -184 on the moneyline (about 65% implied) and Tennessee +150. In Knoxville, the noise and tempo can tilt momentum, but this number signals a game decided at the line of scrimmage. Georgia’s best path is winning early downs—stuffing the run, forcing third-and-long, and preventing the explosive shots that power Tennessee’s offense. With a total sub-50, possessions matter; field position and red-zone efficiency could swing it. If Georgia stays ahead of the chains and protects the ball, their balance should control the final quarter.

Tennessee’s upset path is a fast start plus a positive turnover margin. From a betting perspective, if you like Georgia, the ML trims late-game variance; if you like the Vols, consider the spread given volatility. Straight up, Georgia is the play.

Oregon State vs No. 21 Texas Tech

Moneyline prediction: Texas Tech (-2800)
Odds: Texas Tech -23.5; total 62.5.

The Red Raiders are heavy favorites in Lubbock, and this looks like a tough ask for Oregon State. Tech’s offense should pile up points quickly, and the Beavers will be chasing all game. This is one-sided on paper — Texas Tech takes it.

No. 14 Iowa State vs Arkansas State

Moneyline prediction: Iowa State (-1800)
Odds: Iowa State -20.5; total 55.5.

Iowa State is in no danger of losing this one. Arkansas State can compete early, but over four quarters, the Cyclones’ talent and depth will wear them down. Bettors should be comfortable with a straight-up Iowa State win.

Louisiana vs No. 25 Missouri

Moneyline prediction: Missouri (-7000)
Odds: Missouri -27.5; total 47.5.

Missouri’s defense is one of the best-kept secrets in the SEC, and Louisiana won’t be able to crack it consistently. The Tigers are heavy favorites and should have no trouble controlling this matchup. Straight up, it’s Mizzou with ease.

UTEP vs No. 7 Texas

Moneyline prediction: Texas
Odds: Texas -41.5; total 51.5.

FanDuel has the moneyline locked for now, but Texas is a huge favorite. After a tough early schedule, this is a breather spot. UTEP is simply overmatched against the Longhorns’ depth and speed. Texas dominates at home.

No. 18 South Florida vs No. 5 Miami

Moneyline prediction: Miami (-780)
Odds: Miami -17.5; total 56.5.

An in-state clash, but Miami is the superior team in every phase. South Florida has shown fight, but the Hurricanes’ offense is humming, and their defense can limit big plays. Miami continues its strong start with another statement win.

Vanderbilt vs No. 11 South Carolina

Moneyline prediction: South Carolina (-192)
Odds: South Carolina -4.5; total 48.5.

Vandy’s been a pesky underdog before, but South Carolina is too talented to let this slip. The Gamecocks’ passing attack gives them an edge, and their defense should hold up in the second half. Carolina holds serve at home.

Western Michigan vs No. 9 Illinois

Moneyline prediction: Illinois (-7000)
Odds: Illinois -27.5; total 51.5.

Illinois’ defense is dominant, and Western Michigan doesn’t have the firepower to threaten. The Illini are comfortable favorites, and this is a chance to flex both sides of the ball. Straight up, Illinois is a lock.

Ohio vs No. 1 Ohio State

Moneyline prediction: Ohio State (-10000)
Odds: Ohio State -31.5; total 51.5.

The in-state battle won’t be much of one. The Buckeyes are stacked with depth and star power, and Ohio can’t match the speed. Expect fireworks early, and a safe straight-up bet on Ohio State to remain undefeated.

Arkansas vs No. 17 Mississippi

Moneyline prediction: Mississippi (-260)
Odds: Mississippi -7.5; total 60.5.

Mississippi is laying more than a touchdown, but at home, they’re the clear choice. Arkansas has talent but lacks the consistency to win in Oxford. Expect a high-scoring game, but the Rebels keep the upper hand.

Florida vs No. 3 LSU

Moneyline prediction: LSU (-280)
Odds: LSU -7.5; total 48.5.

This SEC rivalry always delivers intensity. Florida has athletes to compete, but LSU’s balance and Death Valley atmosphere tilt things heavily in the Tigers’ favor. LSU is built for big moments — they’ll win this one.

No. 16 Texas A&M vs No. 8 Notre Dame

Moneyline prediction: Notre Dame (-250)
Odds: Notre Dame -6.5; total 49.5.

A&M travels to South Bend for a prime-time matchup where the market leans Irish: FanDuel shows Notre Dame -250 on the moneyline (about a 72% implied win chance) vs. +210 for A&M, per your screenshot. With a sub-50 total, books expect a modest-scoring game decided by a handful of key drives. That script generally rewards the team that sustains possessions and avoids negative plays—areas where Notre Dame’s home-field advantage and balanced offense provide a margin. 

For A&M to flip it, they likely need explosive plays off play-action or a multi-takeaway edge that shortens fields. If the Irish keep the chains moving on early downs and protect the quarterback, they can dictate tempo and make the Aggies chase. Straight up, the safer side is Notre Dame on the moneyline; laying 6.5 is reasonable, but the ML reduces variance in what could settle around one score.

No. 20 Utah vs Wyoming

Moneyline prediction: Utah (-3000)
Odds: Utah -23.5; total 48.5.

Utah is a sizable favorite for a reason. The Utes’ front seven should control the line of scrimmage and squeeze Wyoming’s scoring chances, while Utah’s offense methodically builds a lead. Laramie can be tricky, but talent and depth point squarely to the visitors. For a straight-up wager, Utah is the pick.