College Football Moneyline Picks for Week 13

The penultimate weekend of the college football regular season has arrived as we turn our attention to Week 13.

Let’s take a closer look at the top games on the board and pick winners for each contest.

Here’s who I have coming away victorious this weekend with my moneyline plays and college football picks for Week 13 on Saturday, November 22.

Week 13 college football moneyline picks

Matchup	Pick
Missouri vs Oklahoma	-300
Louisville vs SMU	-137
USC vs Oregon	-360
Kentucky vs Vanderbilt	-365
Arkansas vs Texas	-350
Duke vs North Carolina	+198
TCU vs Houston	-104
Tennessee vs Florida	-184
BYU vs Cincinnati	-138
Pittsburgh vs Georgia Tech	+114

Lines courtesy of FanDuel as of 11-19.

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Expert Week 13 CFB moneyline picks

Missouri vs. Oklahoma: Oklahoma (-300)

No. 22 Missouri has fallen short every time it's faced a tough opponent, losing to Alabama, Vanderbilt, and Texas A&M. No. 8 Oklahoma’s feisty defense (14.8 ppg allowed, fifth in success rate) will be the best unit on the field, so Brent Venables will need to rely on that side of the ball so long as the offense continues to struggle.

Louisville vs. SMU: SMU (-137)

SMU’s defense has been terrific on standard downs but vulnerable on passing downs due to its leaky secondary. That concern is mitigated against a Louisville offense that has struggled to get the passing attack working all year. SMU will "get right" here.

USC vs. Oregon: Oregon (-360)

One of the top matchups of the weekend still sees No. 7 Oregon as a 9.5-point favorite over No. 15 USC. Dan Lanning’s squad has the defensive prowess to slow down Jayden Maiava and company. On the other side of things, the Ducks will be able to run the ball against USC’s faulty run defense.

Kentucky vs. Vanderbilt: Vanderbilt (-365)

Kentucky has been scrappy en route to a 5-5 record, but Mark Stoops’ squad still doesn’t do much particularly well and is outmatched by the 8-2 Commodores. No. 14 Vanderbilt still has a shot of making the College Football Playoffs, which would be huge for a program of this ilk, so expect a concentrated effort from Diego Pavia and company following the bye week. 

Arkansas vs. Texas: Texas (-350)

All Arkansas has done lately is lose close games. This one could come down to the wire, but I can’t pick Bobby Petrino to pick up his first win as the interim head coach, considering his 0-5 record and the difficult matchup. Even though it’s an uphill battle, No. 17 Texas still has a shot at making the playoffs, and this is a get-right spot at home against one of the nation’s worst defenses.

Duke vs. North Carolina: UNC (+198)

You called for more upsets? How about Bill Belichick as a significant underdog at home in a game where his team will have a huge defensive advantage? Duke played itself out of the ACC race thanks to its moribund defense, so the Tar Heels should be able to score more than usual and then rely on a defense allowing fewer than 4.5 yards per play in four of its last five games. 

TCU vs. Houston: TCU (-104)

Call it like it is — No. 23 Houston has benefitted from a soft schedule en route to a national ranking. The Cougars’ best win was against Arizona State, sans Jordyn Tyson, in a game in which quarterback Sam Leavitt left early due to injury. They’ve also managed to lose to West Virginia and narrowly escape a 2-9 Oregon State team in overtime. It’s a quality matchup for TCU’s defense, which is decent against the run, because that’s what Houston wants to do offensively. 

Tennessee vs. Florida: Tennessee (-184)

No. 20 Tennessee’s offense is the best unit on the field by a mile, according to the metrics. Josh Heupel’s 7-3 squad is the rightful favorite over the 3-7 Florida Gators, who have yet to come away with a win in three attempts under interim head coach Billy Gonzales. 

BYU vs. Cincinnati: BYU (-138)

Just how good is this 7-3 Cincinnati team? It’s hard to tell, but the Bearcats don’t have many quality wins and have lost two in a row now by a combined score of 75 to 38. The defense has been a problem all year, whereas BYU is solid on both sides of the ball, so here’s betting Kalani Sitake’s squad exposes the Cincinnati “stop unit” for a third consecutive game.

Pittsburgh vs. Georgia Tech: Pitt (+114)

This one is likely to be a back-and-forth shootout with high volatility, and the outcome matters a lot in the ACC race. This matchup sets up well for Pitt on paper because its vaunted passing attack should find success against a miserable No. 16 Georgia Tech secondary. While on defense, Pitt shuts down the running game, and that’s where Tech excels. I can’t trust Brent Key’s team after it allowed over 8.0 yards per play in two consecutive games.

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