College Football Best Bets & Predictions for Week 7 Early Games

College football best bets for Week 7 early games, including Ohio State vs. Illinois, Alabama vs. Missouri, and Pittsburgh vs. Florida State.

Jared Hochman - Content Operations Manager at Covers.com
Jared Hochman • Content Manager
Oct 11, 2025 • 07:59 ET • 3 min read
College football best bets early games Week 7 Ty Simpson
Photo By - Imagn Images. Alabama quarterback Ty Simpson (15) throws for a touchdown.

The noon slate for this week's college football schedule is highlighted by Illinois hosting No. Ohio State for the FOX Big Noon Kickoff, along with Alabama taking on Missouri and Florida State hosting Pittsburgh.

Covers' college football experts have a best bet for each of those games and more — read on for our college football picks and analysis!

College football best bets for Week 7 early games

Game Time (ET)
Network
Best bet
Ohio State vs Illinois 12:00 | FOX Ohio State Smith 2+ TD
+240
Alabama vs Missouri 12:00 | ABC Alabama -3.5
-104
Pittsburgh vs Florida State 12:00 | ESPN Pittsburgh +10.5
-118
Houston vs Oklahoma State 12:00 | TNT Houston -14.5
-110
Washington State vs Mississippi 12:00 | SECN Mississippi -33.5
-105
Toledo vs Bowling Green 12:00 | ESPNU Bowling Green +10.5
-110

CFB Week 7 preview with Andrew Caley and Douglas Farmer


Ohio State vs Illinois best bet

Jeremiah Smith 2+ touchdowns (+240at FanDuel)

Jeremiah Smith is the best receiver in the country and proud owner of six touchdowns in the last four games. His anytime touchdown prop is at -210, while an additional score offers a +240 payday — that difference in price is too steep when one score from Smith should be rather assured, given how atrocious Illinois’s pass defense has become.

See our full analysis and Buckeyes/Fighting Illini SGP in our Ohio State vs. Illinois predictions.

Alabama vs Missouri best bet

Alabama -3.5 (-104 at FanDuel)

Missouri’s undefeated record is impressive, yet its schedule has been far lighter than Alabama’s, which includes back-to-back wins over ranked SEC opponents, highlighted by a road victory at Georgia.

See our full analysis and Crimson Tide/Tigers SGP in our Alabama vs. Missouri predictions.

Pittsburgh vs Florida State best bet

Pittsburgh +10.5 (-118 at FanDuel)

Pittsburgh can score points, coming off a 48-point performance against Boston College, and the Panthers are absolutely shutting down opponents on the ground, giving up just 1.7 yards per rushing attempt. That should be enough to keep them in the game.

See our full analysis and Panthers/Seminoles SGP in our Pittsburgh vs. Florida State predictions.

Houston vs Oklahoma State best bet

Houston -14.5 (-110 at FanDuel)

There are no redeeming qualities coming out of this Oklahoma State team; it has been crushed in back-to-back losses to Baylor and Arizona, and in its four straight losses, only Tulsa failed to blow them out, winning 19-12.

See our full analysis and Cougars/Cowboys SGP in our Houston vs. Oklahoma State predictions.

Washington State vs Mississippi best bet

Mississippi -33.5 (-105 at FanDuel)

Expect Lane Kiffin to push tempo and keep his starters rolling well into the second half. Mississippi will hog the time of possession and force WSU’s defense into exhaustion... because that’s what they do.

See our full analysis and Cougars/Rebels SGP in our Washington State vs. Mississippi predictions.

Bowling Green vs Toledo best bet

Bowling Green +10.5 (-110 at FanDuel)

Toledo head coach Jason Candle has lost 16 times outright as a favorite since 2021... 11 of those as a double-digit favorite.

See more picks and our college football Week 7 breakdown on the Covers YouTube channel.


Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jared Hochman Content Operations Manager at Covers.com
Content Manager

Before Jared Hochman joined the Covers team in 2020, he worked for newspaper outlets such as the Chronicle Herald and The Coast, worked in marketing for SkipTheDishes and Vivid Seats, and previously ran a magazine. A journalism graduate from the University of King's College in, Halifax, N.S., "Hoch" brings more than a decade of experience in sports betting, having worked as a freelance handicapper, making appearances on Monumental Sports Network and the Sharp 600 podcast, and now also filling in occasionally as host of Covers' NHL Puck Props. 

Awarded Covers' company MVP for 2023, Jared is an avid bettor of MLB, NFL, NHL, and NBA, while also wagering on some soccer and WNBA. His best advice for sports bettors? Price shop, which is something he does daily across 10 different sportsbook apps.

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