After suffering their first loss of the season, the Houston Cougars will look to work their way back into the win column when they visit the Oklahoma State Cowboys.
It’s been a nightmare season for the Cowboys, who have already fired their head coach and the losing continues, as they’ve dropped four in a row.
Check out my Houston vs. Oklahoma State predictions on what wager I like best, and all our college football picks for this Big 12 tilt on Saturday, October 11.
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Houston vs Oklahoma State prediction
Houston vs Oklahoma State best bet: Houston -14.5 (-110)
Normally, I’d steer clear of a spread that big, but there’s no redeeming qualities coming out of this Oklahoma State team.
They have been crushed in back-to-back losses to Baylor (45-27) and last week to Arizona (41-13). In their four straight losses, only Tulsa failed to blow them out, winning 19-12.
They’re also down quarterback Zane Flores, who hurt his shoulder in the loss to Arizona.
That leaves them with freshman Banks Bowen, and Sam Jackson, who had converted to wide receiver last year while at Auburn. He replaced Flores against Arizona and threw for 27 yards on 3-for-6 passing.
Houston’s pivot problem is more encouraging, as Conner Weigman went into concussion protocol after leaving their 35-11 loss to Texas Tech in the second quarter.
After building a solid 4-0 mark, Weigman’s injury derailed the Cougars’ litmus test against its first ranked opponent on the year. He had thrown for 93 yards and a score before leaving the game, and Houston didn’t score another point.
Assuming he does play, he’ll lead a Houston Cougars offense averaging 27.2 points per game. Oklahoma State is averaging a paltry 16.4 points per contest, and their defense is 130th or worse in total yards and passing yards per game, while ranking 112th against the rush, at 179.4 per contest.
Houston vs Oklahoma State same-game parlay
During this current four-game losing slide, Oklahoma State has trailed by at least seven points in three of them. The only game they came out even was against Baylor, tied 7-7 after the first 15 minutes.
In Houston’s four wins, they came out of the opening quarter with at least a seven-point lead twice, and in a scoreless draw in another.
They should be in position to get ahead in this one on Saturday.
Houston vs Oklahoma State SGP
- Houston -14.5
- Under 46.5
- Houston -3.5 first quarter spread
Houston vs Oklahoma State odds
- Spread: Houston -14.5 (-110) | Oklahoma State +14.5 (-110)
- Moneyline: Houston -620 | Oklahoma State +460
- Over/Under: Over 46.5 (-115) | Under 46.5 (-105)
Houston vs Oklahoma State trend to know
Oklahoma State has failed to cover the spread in nine of its last 10 games. Find more college football betting trends for Houston vs Oklahoma State.
How to watch Houston vs Oklahoma State
| Location | Boone Pickens Stadium, Stillwater, OK |
| Date | Saturday, October 11, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | TNT |
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Odds are correct at the time of publishing and are subject to change.
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