College Football Best Bets & Predictions for Week 13 Early Games

College football best bets for Week 13 early games, including Missouri vs. Oklahoma, Rutgers vs. Ohio State, and Miami vs. Virginia Tech.

Jared Hochman - Content Operations Manager at Covers.com
Jared Hochman • Content Manager
Nov 22, 2025 • 07:59 ET • 3 min read
College football best bets early games Week 13 Damon Wilson II
Photo By - Imagn Images. Missouri Tigers defensive end Damon Wilson II (8) celebrates after recovering a fumble.

The noon slate for this week's college football schedule is highlighted by an SEC matchup between Missouri and Oklahoma, plus No. 1-ranked Ohio State is in action.

Covers' college football experts have a best bet for both of those games and more — read on for our college football picks and analysis!

College football best bets for Week 13 early games

Game Time (ET)
Network
Best bet
Missouri vs Oklahoma 12:00 | ABC Missouri +7.5
-120
Rutgers vs Ohio State 12:00 | FOX Over 55.5
-110
Miami vs Virginia Tech 12:00 | ESPN Miami -18.5
-105
Baylor vs Arizona 1:00 | TNT Arizona -7
-110
Washington State vs James Madison 1:00 | ESPN+ James Madison -19.5
+180
Marshall vs Appalachian State 2:30 | ESPN+ Over 54.5
-114
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CFB Week 13 preview with Andrew Caley and Douglas Farmer


Missouri vs Oklahoma best bet

Missouri +7.5 (-120 at FanDuel)

Looking at the Sooners’ losses, they did not manage a touchdown against Texas and averaged 1.75 points per quality drive against Mississippi. In last week’s upset of Alabama, they again averaged 1.75 points per quality drive. That can be survived when the defense scores, but I'm expecting Missouri to play it safe, protect the ball, and see how Oklahoma reacts.

See our full analysis and Tigers/Sooners SGP in our Missouri vs. Oklahoma predictions.

Rutgers vs Ohio State best bet

Over 55.5 (-110 at FanDuel)

The Buckeyes will blow out Rutgers, and while the Ohio State defense might be the star of the show, the weakness of the Scarlet Knights' defense also means that the No. 1 team in the nation will light up the scoreboard early and often.

See our full analysis and Scarlet Knights/Buckeyes SGP in our Rutgers vs. Ohio State predictions.

Miami vs Virginia Tech best bet

Miami -18.5 (-105 at FanDuel)

The Hurricanes are the vastly superior team, and they need style points to boost their chances of an at-large bid in the College Football Playoff. The Hokies are 2-8 ATS this season and were just blown out 34-14 by Florida State. The going doesn’t get any easier in Week 13.

See our full analysis and Hurricanes/Hokies SGP in our Miami vs. Virginia Tech predictions.

Baylor vs Arizona best bet

Arizona -7.5 (-105 at FanDuel)

Arizona has leaned on its ground game more in recent weeks, particularly when recognizing a matchup edge. It genuinely ran through both Colorado and Cincinnati, and embarrassed Kansas between those two. The Wildcats should run all over the Bears, quite possibly turning the second half into a blowout.

See Douglas' full analysis, plus his other Week 13 best bets, in his college football predictions for Week 13.

Washington State vs James Madison best bet

James Madison -19.5 (+180 at FanDuel)

Betting this alternate spread is betting that the Dukes will not consider giving up a late, meaningless score. The scoreboard optics matter too much to them. Washington State lacks any particular strength, and while the Cougars are still alive for a bowl game, the more important item for them is next week, facing Oregon State for a second time this season.

See Douglas' full analysis, plus his other Week 13 best bets, in his college football predictions for Week 13.

Marshall vs App State best bet

Over 54.5 (-114 at FanDuel)

I made this number 59. Marshall games have gone Over the total by an average of 10 points per game, while Appalachian State is Top 10 in the country in plays run per minute.

See more picks and our college football Week 13 breakdown on the Covers YouTube channel.


Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Jared Hochman Content Operations Manager at Covers.com
Content Manager

Before Jared Hochman joined the Covers team in 2020, he worked for newspaper outlets such as the Chronicle Herald and The Coast, worked in marketing for SkipTheDishes and Vivid Seats, and previously ran a magazine. A journalism graduate from the University of King's College in, Halifax, N.S., "Hoch" brings more than a decade of experience in sports betting, having worked as a freelance handicapper, making appearances on Monumental Sports Network and the Sharp 600 podcast, and now also filling in occasionally as host of Covers' NHL Puck Props. 

Awarded Covers' company MVP for 2023, Jared is an avid bettor of MLB, NFL, NHL, and NBA, while also wagering on some soccer and WNBA. His best advice for sports bettors? Price shop, which is something he does daily across 10 different sportsbook apps.

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