The Ohio State Buckeyes will look to run their record to 11-0 on Saturday as they play host to the Rutgers Scarlet Knights.
Expect the Buckeyes to run up the score at home, and that has me targeting the Over in my Ohio State vs. Rutgers predictions.
Let’s dive into this Week 13 matchup with my free college football picks for November 22.
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Rutgers vs Ohio State prediction
Rutgers vs Ohio State best bet: Over 55.5 (-110)
Ohio State is going to have to make sure it’s not looking ahead a week to its marquee matchup with Michigan, but other than that, there’s little worry for the home team on Saturday.
The Buckeyes will blow out Rutgers, and while the Ohio State defense might be the star of the show, the weakness of the Scarlet Knights' defense also means that the No. 1 team in the nation will light up the scoreboard early and often.
Rutgers is allowing 425.5 yards and 30.0 yards per game on the season, and it is among the worst defenses against both the run (6.6 yards per rush) and the pass (8.5 yards per attempt). Bo Jackson, James Peoples, and CJ Donaldson (if available) should run roughshod over the Scarlet Knights, while Julian Sayin and his 80.1% completion percentage will light up Rutgers through the air.
Although the Scarlet Knights are averaging a middling 29.9 ppg, I’m counting on them putting up at least 10 points to help cash the Over.
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Rutgers vs Ohio State same-game parlay
While I’m taking the Over as my best bet, Ohio State is also a great bet to win against the spread, as the Buckeyes have already won by 33+ points on four occasions this year.
That will mean plenty of play for the running game, so I’m taking Bo Jackson to hit his yardage total and James Peoples to add to the two touchdowns he scored last week.
Rutgers vs Ohio State SGP
- Over 55.5
- Ohio State -32.5
- Bo Jackson Over 89.5 rushing yards
- James Peoples anytime touchdown
Our deep-ball SGP: That's What I'm Sayin'
There will also be plenty of offense available for the Buckeyes' passing game on Saturday, and Sayin has eclipsed this yardage total in three of his last four contests.
Rutgers vs Ohio State SGP
- Over 55.5
- Ohio State -32.5
- Bo Jackson Over 89.5 rushing yards
- James Peoples anytime touchdown
- Julian Sayin Over 274.5 passing yards
Rutgers vs Ohio State odds
- Spread: Rutgers +33 (-110) | Ohio State -33 (-110)
- Moneyline: Rutgers +4000 | Ohio State -50000
- Over/Under: Over 57 (-110) | Under 57 (-110)
Rutgers vs Ohio State trend to know
The Over is 5-0 in the last five head-to-head meetings. Find more college football betting trends for Rutgers vs Ohio State.
How to watch Rutgers vs Ohio State
| Location | Ohio Stadium, Columbus, OH |
| Date | Saturday, November 22, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | FOX |
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Odds are correct at the time of publishing and are subject to change.
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