College Football Week 10 Against the Spread Picks for the Biggest Games

While Penn State's 7-0 resume lacks a statement victory, that could certainly change with No. 4 Ohio State coming to town in Week 10. That Big Ten battle highlights our best ATS picks below.

Chris Gregory - Publishing Editor at Covers.com
Chris Gregory • Publishing Editor
Oct 31, 2024 • 11:00 ET • 4 min read
Drew Allar Penn State
Photo By - Imagn Images

The Week 10 college football odds are centered around a massive Big Ten showdown, with No. 4 Ohio State heading to Happy Valley to take on undefeated No. 3 Penn State.

I have college football picks for that matchup and much more below.

College football Week 10 picks against the spread

Matchup Pick
Ohio State Ohio State vs Penn State Penn State Penn State +3.5
Duke Duke vs Miami Miami Duke +21
Mississippi Mississippi vs Arkansas Arkansas Arkansas +7
Oregon Oregon vs Michigan Michigan Oregon -15
Florida Florida vs Georgia Georgia Florida +16.5
Louisville Louisville vs Clemson Clemson Clemson -10.5
Texas A&M Texas A&M vs NFC South Carolina Texas A&M -2.5
Kentucky Kentucky vs Tennessee Tennessee Tennessee -16.5

Lines courtesy of DraftKings as of 10-29.

CFB Week 10 ATS picks

Ohio State (-3.5) vs. Penn State: Penn State +3.5

While Penn State historically comes up short in games like this, nothing about the Buckeyes' performance against Nebraska instills the confidence you need to back them here.

Duke vs. Miami (-21): Duke +21

Not to suggest Duke will shut Miami down, but it's allowed more than 24 points just once in eight games this season. I'll take the points.

Mississippi (-7) vs. Arkansas: Arkansas +7

Give me the touchdown with the home team that beat Tennessee outright and had a fourth-quarter lead over Texas A&M at Kyle Field. 

Oregon (-15) vs. Michigan: Oregon -15

I might need three full touchdowns to consider jumping the fence to Michigan. Oregon rolls and moves to 9-0. 

Florida vs. Georgia (-16.5): Florida +16.5 

You'd think Georgia would start to roll after taking Texas in Austin, but Florida has covered in four straight and won as an outright underdog in two of those games.

Louisville vs. Clemson (-10.5): Clemson -10.5

If not for scheduling Georgia instead of a nobody in Week 1, Clemson would be ranked as high as Miami or even Penn State. Full steam ahead for Cade Clubnik & Co.

Texas A&M (-2.5) vs. South Carolina: Texas A&M -2.5

One of these teams should have beaten LSU, and the other actually did... by 15. Texas A&M gets the win and stays undefeated in SEC play.

Kentucky vs. Tennessee (-16.5): Tennessee +16.5

While acknowledging the concerns I still have for Tennessee's offense, Kentucky has scored 43 total points over its last three games against Vanderbilt, Florida, and Auburn (all losses). 

Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.

Pages related to this topic

Chris Gregory Covers.com
Publishing Editor

In his three years on the Covers editorial team, Chris Gregory has helped bolster the site’s PGA Tour and college football coverage, though his love for Rory McIlroy and the Buckeyes is often met with disappointment. He brings a journalism and marketing background to his work as a Publishing Editor and has appeared on Jason Logan’s Sharp 600 to talk about the Masters and golf’s other majors.

His best betting advice? Stay away from betting your favorite teams; it’ll only make the hurt worse.

Popular Content

Legal Canadian sports betting

Best Canadian betting sites Ontario sports betting
Covers 25 Years Logo Established in 1995,
Covers is the world
leader in sports
betting information.
Covers is verified safe by: Evalon Logo GPWA Logo GDPR Logo GeoTrust Logo Evalon Logo