Lakers vs Clippers Prediction, Picks & Odds for Tonight’s NBA Game

Oldfield's prediction: LeBron does the dirty work.

Tom Oldfield - Contributor at Covers.com
Tom Oldfield • Betting Analyst
Jan 22, 2026 • 13:59 ET • 4 min read

NBA

Match starts: 6 hrs
LAC
51 %
LAL
49 %
EXPERT PICK - PROP
LeBron James o12.5  Rebounds and Assists (-112) LeBron James o12.5 Rebounds and Assists (-112)
Read Analysis
Los Angeles Lakers forward LeBron James (23) moves to the basket.
Photo By - Reuters Connect. Los Angeles Lakers forward LeBron James (23) moves to the basket.

As we hit the halfway point in the NBA schedule, the Los Angeles Clippers finally seem to be salvaging their season, but that progress will be tested tonight when they host the Los Angeles Lakers at Intuit Dome.

The Battle of L.A. season series sits at 1-1 heading into this matchup, and my Lakers vs. Clippers predictions expect LeBron James to be one of the swing factors here for the visitors.

Take a closer look at this marquee January 22 showdown with my free NBA picks.

Lakers vs Clippers prediction

Lakers vs Clippers best bet: LeBron James Over 12.5 rebounds + assists (-112 Bet365)

LeBron James' injury issues may point to a 41-year-old in his 23rd season, but his stat lines suggest he’s got something left in the tank. James has been able to keep his sciatica and arthritis at bay while starting 2026 with a bang, so look for his fingerprints to be all over tonight’s clash with the Los Angeles Clippers.

With Luka Doncic doing so much of the scoring for the Los Angeles Lakers, I’m targeting LeBron’s rebounds and assists here, and he’s gone past this combo O/U number in four of his past five outings.

James has been getting the job done in both these categories so far this month, with averages of 7.7 RPG and 7.6 APG in January, and he was closing in on a triple-double in L.A.’s win over the Denver Nuggets earlier this week.

Until Austin Reaves returns, LeBron is going to have a larger share of the playmaking, particularly when Luka is on the bench, and there’s just not a lot of secondary ball-handling in the current rotation. Equally, he’s got a big role to play alongside Deandre Ayton on the boards.

At this stage of his career, James can still do the little things that drive winning, and the Lakers will need all of that veteran savvy to hold off their cross-city rivals tonight.

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Lakers vs Clippers same-game parlay

The Lakers are 7-3 SU in their last 10 meetings with the Clippers, and an impressive 14-8 on the road this season. With Kawhi Leonard still listed as questionable, the burden on James Harden could once again be massive, and the hosts gave up 138 points to the Chicago Bulls this week.

Harden continues to put up big numbers, and I’ll take the Over on his rebounds prop here. He’s grabbed 4+ boards in six of his last seven games, and the Clippers will gladly keep him closer to the rim if it avoids the Luka defensive assignment.

Lakers vs Clippers SGP

  • James Over 12.5 reb+ast
  • Lakers moneyline
  • Harden Over 3.5 rebounds

Our "from downtown" SGP: Brick by brick

Ivica Zubac has had some miserable possessions trying to guard Doncic on switches in the past, but the Clippers will lean on him for big minutes here. Zubac has posted three straight double-doubles, and he’s finished with 11+ rebounds in his last four games. 

Lakers vs Clippers SGP

  • James Over 12.5 reb+ast
  • Lakers moneyline
  • Harden Over 3.5 rebounds
  • Zubac double-double

Lakers vs Clippers odds

  • Spread: Lakers -1.5 (+100) | Clippers +1.5 (-120)
  • Moneyline: Lakers -110 | Clippers -110
  • Over/Under: Over 223.5 (-110) | Under 223.5 (-110)

Lakers vs Clippers betting trend to know

The Lakers are 5-2 ATS in the last seven meetings between these teams. Find more NBA betting trends for Lakers vs. Clippers.

How to watch Lakers vs Clippers

Location Intuit Dome, Inglewood, CA
Date Thursday, January 22, 2026
Tip-off 10:00 p.m. ET
TV Prime Video

Lakers vs Clippers latest injuries

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Tom Oldfield - Covers
Betting Analyst

Tom Oldfield’s sports writing journey over the past 20 years has taken him from the Premier League and Champions League to the NFL, NBA, WNBA and MLB, with a wide range of articles and betting previews. Tom has worked closely with London’s Sportsbeat sports news agency as well as (thrillingly!) covering the Toronto Raptors’ 2019 NBA championship run, and he has appeared on BBC World Service and The Back Page podcast.

A graduate of the University of Nottingham in the UK, he is the author of biographies on Cristiano Ronaldo, Rafael Nadal, Gary Neville and Cesc Fabregas, and he co-authors a long-running series of children’s soccer books with his brother, Matt.

As a regular bettor across the top sports leagues, particularly with FanDuel and bet365, he is well versed on all the major markets and the next big game is rarely far from his thoughts. The best betting advice he has received is to monitor multiple sportsbooks to grab the best possible value.

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