The New York Yankees and San Francisco Giants open the 2026 season at Oracle Park on Wednesday, March 25, and I’ve got a trio of MLB picks to cover you for the action.
My top Yankees vs. Giants predictions expect San Francisco ace Logan Webb to have his hands full navigating a tough and talented New York lineup tonight.
Yankees vs Giants props for March 25
| Pick | Odds |
|---|---|
 Logan Webb Under 6.5 strikeouts |
-146 |
 Ben Rice Over 1.5 hits + runs + RBI |
-115 |
| Jazz Chisholm Over 1.5 hits + runs + RBI |
+130 |
Yankees vs Giants player prop picks
Logan Webb Under 6.5 strikeouts (-146)
The New York Yankees paced the majors in wOBA and ISO against right-handed pitchers last season, and San Francisco Giants righty Logan Webb fanned six or fewer batters in 19 of 34 starts.
Additionally, between the World Baseball Classic and Spring Training, Webb has only thrown 18 innings across five starts, so I’m not convinced he’ll pitch deep enough into this game to record seven or more strikeouts.
Ben Rice Over 1.5 hits + runs + RBI (-115)
Yankees first baseman Ben Rice is set to hit in the heart of the lineup after posting a rock-solid .371 wOBA and .860 OPS against right-handed pitchers last season. He also had a productive spring with 11 hits, seven runs, and five RBI across 51 plate appearances.
Jazz Chisholm Over 1.5 hits + runs + RBI
Yankees second baseman Jazz Chisholm posted an impressive .360 wOBA and .267 ISO against righties last season, and he’s set to see plenty of opportunities to score and drive in runs, hitting in the lower-middle half of the lineup.
Chisholm has also been ramping up this spring with three runs, seven hits, and five RBI across just 36 plate appearances, and he posted two runs, four hits, and four RBI through four games in the World Baseball Classic.
How to watch Yankees vs Giants and game info
| Location | Oracle Park, San Francisco, California |
| Date | Wednesday, March 25, 2026 |
| First pitch | 8:05 p.m. ET |
| TV | Netflix |
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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