The Chicago White Sox visit the Seattle Mariners for a midweek series with momentum on their side.
After winning two out of three over the first-place Cubs, the Sox have won their last three series and five of the last six. Meanwhile, the Mariners have lost three in a row and six of the last nine.
That’s why my White Sox vs. Mariners predictions and MLB picks call for a Chicago road win.
Who will win White Sox vs Mariners today: White Sox (+150)
The Chicago White Sox have won seven of eight and are three games better than the Seattle Mariners. While they’re on the road and starting a less experienced pitcher, this is still a lopsided underdog price.
Chicago has scored 5+ runs in the last six games and eight of the last nine, averaging 6.2 runs per game over that stretch, which includes scoring 16 in three games against Seattle.
Seattle starter Bryan Woo’s fastball hasn’t been as effective as it was last season, while Chicago rookie Noah Schultz has better hit and homer per nine rates this season.
COVERS INTEL: Bryan Woo has lost about 40 revolutions of spin on both his four-seamer and sinker, and batters have noticed. They’re hitting more than 50 points higher against each pitch, while swinging and missing far less often.
White Sox vs Mariners Over/Under pick: Over 7.5 (-106)
The Mariners have plated four or fewer in seven of the last nine, and J.P. Crawford left Sunday’s game after getting hit by a pitch. Seattle called up top prospect Colt Emerson, who had an .816 OPS in Triple-A and should add power to the left side of the infield.
Seattle scored 12 runs against Chicago earlier this month and could put up some runs against Schultz, who struggles with control. He’s walking more than six batters per nine, which could be trouble against a Mariners lineup that ranks third in the AL in walks drawn.
- ML/RL bets: 13-18, -4.33 units
- Over/Under bets: 18-17, -0.51 units
White Sox vs Mariners odds
- Moneyline: White Sox +150 | Mariners -165
- Run line: White Sox +1.5 (-160) | Mariners -1.5 (+135)
- Over/Under: Over 7.5 (-106) | Under 7.5 (-118)
White Sox vs Mariners trend
The White Sox have cashed the moneyline in 17 of their last 25 games for +10.75 units and a 41% ROI. Find more MLB betting trends for White Sox vs. Mariners.
How to watch White Sox vs Mariners and game info
| Location | T-Mobile Park, Seattle, WA |
| Date | Monday, May 18, 2026 |
| First pitch | 9:40 p.m. ET |
| TV | CHSN, Mariners.TV |
| White Sox starting pitcher | Noah Schultz (2-2, 4.91 ERA) |
| Mariners starting pitcher | Bryan Woo (3-2, 3.91 ERA) |
White Sox vs Mariners latest injuries
White Sox vs Mariners weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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