The Chicago White Sox and Milwaukee Brewers begin their 2026 campaign this afternoon with the series opener of a three-game set at American Family Field.
Jacob Misiorowski gets the baseball for the hosts, and my White Sox vs. Brewers predictions are eyeing him to be lights out on Opening Day.
Read more for my MLB picks for Thursday, March 25.
White Sox vs Brewers predictions
White Sox vs Brewers best bet: Jacob Misioroski Over 5.5 strikeouts (-152)
Milwaukee Brewers right-hander Jacob Misiorowski was solid in a brief 15 appearances in his rookie season in 2025, pitching to a 5-3 record and 4.36 ERA. The youngster has serious swing and miss stuff, and that was clear from his 87 strikeouts in just 66 innings of work.
While the righty has never faced the Chicago White Sox, they were 15th in the majors last season in team strikeouts with nearly nine per game.
Misiorowski cashed the Over in Ks in two of his three starts in spring training, and the adrenaline will be at an all-time high for his first career Opening Day start.
He’ll miss numerous bats in the series opener.
COVERS INTEL: Misiorowski struck out a lot more hitters in Milwaukee last year, racking up 53 Ks in 36 2/3 innings of work compared to just 34 strikeouts in 29 1/3 frames on the road.
White Sox vs Brewers same-game parlay (SGP)
William Contreras is a perfect 2-for-2 lifetime vs. White Sox starter Shane Smith with a pair of singles. That's a small sample size, but he also swung it relatively well in spring training, collecting at least one hit in seven of his eight appearances.
Sal Frelick has faced Smith three times, and his lone hit was a double. He also had a double in two of his final three Cactus League contests. The outfielder also ranked in the 87th percentile in sprint speed, making it easier for him to stretch a single into a double or to ensure he gets into second on a hard-hit ball in the gap.
The Brew Crew is 8-1 in its last nine meetings with Chicago, and the last time the White Sox came to American Family Field, Milwaukee swept them. Misiorowski will throw a gem and set the tone.
White Sox vs Brewers SGP
- William Contreras to hit a single
- Sal Frelick to hit a double
- Brewers moneyline
White Sox vs Brewers home run pick: Christian Yelich (+540)
Christian Yelich had a bounce-back campaign in ‘25, smacking 29 home runs. That was his highest total since 2019, when he went deep 44 times. Twenty-five of his bombs last year were off right-handed pitchers, and Smith surrendered 17 long balls in 2025, with 13 coming off the bat of lefties.
Yelich also went yard 14 times at home. He got some confidence back last year, and I like him to start the campaign with a bang.
White Sox vs Brewers odds
- Moneyline: Chicago +154 | Milwaukee -184
- Run line: Chicago +1.5 (-138) | Milwaukee -1.5 (+116)
- Over/Under: Over 8 (-105) | Under 8 (-115)
White Sox vs Brewers trend
The Milwaukee Brewers have hit the Moneyline in 86 of their last 142 games (+21.35 Units / 11% ROI). Find more MLB betting trends for White Sox vs. Brewers.
How to watch White Sox vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Thursday, March 26, 2026 |
| First pitch | 2:10 p.m. ET |
| TV | Chicago Sports Network, Brewers TV |
| White Sox starting pitcher | Shane Smith (2025: 7-8, 3.81 ERA) |
| Brewers starting pitcher | Jacob Misiorowski (2025: 5-3, 4.36 ERA) |
White Sox vs Brewers latest injuries
White Sox vs Brewers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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