The 2026 Boston Red Sox nightmare rolls on tonight with a trip to the Detroit Tigers, and Tarik Skubal is primed to add to the misery.
At 13-21, Boston is rock bottom in the AL East, and my Red Sox vs Tigers predictions signal home cooking for Detroit here, behind a dominant Skubal start.
Read on for my free MLB picks for Monday, May 4.
Who will win Red Sox vs Tigers today: Tigers (-191)
The Detroit Tigers have issues to resolve on the road, but they’ve been a different animal at Comerica Park through the first six weeks of the season. Boasting a 12-3 mark at home, Detroit is understandably favored here against a Boston Red Sox squad that’s lost four of its past five contests.
The Tigers have a big edge in tonight’s pitching matchup, as Tarik Skubal faces fellow lefty Payton Tolle — and the hosts are 3-1 in their ace’s last four starts.
There’s also the benefit of having seen Skubal rip through this Boston lineup last month, racking up 10 strikeouts.
COVERS INTEL: The Red Sox have lost each of Tolle’s last five outings, and he’s leaked 2+ runs inside the first three innings in three of his past four appearances.
Red Sox vs Tigers Over/Under pick: Under 7 (-120)
With the Under hitting in five of Detroit’s last six games, I’m going back to the well again today and picking a low-scoring battle, especially as Boston has scored just eight runs across its past five contests.
Though Tolle is a bit of a wildcard, having logged five career starts, he’s only allowed six hits in his two 2026 outings. Meanwhile, you know what to expect from Skubal, who enters with a 2.70 ERA and should feast on the Red Sox's struggling lineup.
It's also worth noting that the Under is 5-2 in the last seven meetings between these teams.
- ML/RL bets: 1-5, -4.36 units
- Over/Under bets: 5-1, +3.54 units
Red Sox vs Tigers odds
- Moneyline: Red Sox +200 | Tigers -186
- Run line: Red Sox +1.5 (-140) | Tigers -1.5 (+120)
- Over/Under: Over 7.5 | Under 7.5
Red Sox vs Tigers trend
The Red Sox are 7-11 on the road this season. Find more MLB betting trends for Red Sox vs. Tigers.
How to watch Red Sox vs Tigers and game info
| Location | Comerica Park, Detroit, MI |
| Date | Monday, May 4, 2026 |
| First pitch | 6:40 p.m. ET |
| TV | NESN, DSN |
| Red Sox starting pitcher | Payton Tolle (0-1, 3.38 ERA) |
| Tigers starting pitcher | Tarik Skubal (3-2, 2.70 ERA) |
Red Sox vs Tigers latest injuries
Red Sox vs Tigers weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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