On Tuesday, the San Francisco Giants beat up on the San Diego Padres, earning a 13-2 victory at Oracle Park. These two clubs will now meet again on Wednesday with the winner taking the three-game series.
Will San Francisco show up in a big way for the second game in a row? Check out our Padres vs. Giants MLB picks and predictions to find out.
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Padres vs Giants odds
This odds widget represents the best odds available for each betting market from regulated sportsbooks.
The Giants opened as -119 favorites in this game but the line has moved a decent amount since then. San Francisco’s best number is now -128, with the team being as high as a -141 favorite at one book.
The total in this game opened very low at 7.5 but it might not be low enough. You have to pay a hefty price to take the Under in this one, and there is actually one book that has it at 7.
Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full MLB odds before placing your bets.
Padres vs Giants predictions
Picks made on 4/13/2022 at 10:00 a.m. ET.
Click on each pick to jump to the full analysis.
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Padres vs Giants game info
• Location: Oracle Park, San Francisco, CA
• Date: Wednesday, April 13, 2022
• First pitch: 3:45 p.m. ET
• TV: Bally Sports, NBCS-BAY
Padres vs Giants betting preview
Starting pitchers
Sean Manaea (1-0, 0.00 ERA): Manaea was a big-time acquisition for this Padres team, as the lefty has a ton of talent and can offer a lot to a winning team. The 30-year-old looked very comfortable in his first start with the Padres, as he threw seven innings of shutout ball and didn’t allow a single hit against the Arizona Diamondbacks. He also had seven strikeouts in that brilliant outing.
Logan Webb (0-0, 1.50 ERA): Like Manaea, Webb also turned in a really good performance in his first start of the year. The righty gave up just one earned run in six innings of work against the Miami Marlins, but his team didn’t do enough offensively for him to earn the win — although they did end up winning in extra innings. Webb will be hoping his team can do a little more to get him in the win column here.
Weather
Be sure to monitor the gametime conditions with our MLB weather info.
Key injuries
Padres: Blake Snell P (Out), Fernando Tatis Jr. SS (Out), Mike Clevinger P (Out).
Giants: Evan Longoria 3B (Out).
Find our latest MLB injury reports.
Betting trend to know
The Giants are 37-14 in their last 51 games as favorites. Find more MLB betting trends for Padres vs. Giants.
Padres vs Giants picks and predictions
Our side and total predictions are based upon our analysis of the line and total in this game. Our best bet is our favorite pick across all markets.
Moneyline analysis
For starters, this San Francisco team rarely loses games it's supposed to win. The Giants are 37-14 in their last 51 games as favorites as well as 46-19 in their last 65 as home favorites.
In last night's game, San Francisco put up 13 runs. The Giants' bats were so good the Padres even put in outfielder Wil Myers as a reliever. The team had already burned through four relievers and couldn’t afford to tire out another one.
The fact that the Padres had to use four relievers for at least an inning apiece is pretty significant entering this game. The Padres and Giants are both throwing some excellent starters on the mound in this contest and the low-end total suggests that this should be a very low-scoring game.
With that in mind, this game could end up coming down to the bullpens. San Diego’s, which is already going to be a bit tired with this being an afternoon game, has the fifth-worst team ERA in baseball thus far. The Padres bullpen has already given up five homers (second-most in baseball) and has the fourth-highest collective WHIP.
It wouldn’t be surprising if one of the Padres relievers slips up and ends up letting the Giants turn in one productive inning. And all in all, that could end up being the difference in a game like this.
Manaea, who was stellar in his first start of the year, gave up just three earned runs over 10 innings in two starts against the Giants last year, and he is coming off an impressive season, in general. On the flip side, Webb is always reliable for the Giants, as he hasn’t lost a start since May 5, 2021.
With that considered, you can count on both of these starters to show up in a big way in this game, making this a decision of which bullpen you trust more. The answer should be San Francisco.
Prediction: Giants moneyline (-128 at WynnBet)
Over/Under analysis
In seven career starts against the Giants, Manaea is 2-2 with a 2.68 ERA. He has generally been very good in this matchup and that isn’t too surprising when you consider that the Giants are more so built to beat up on right-handed pitchers. Guys like Brandon Crawford and Brandon Belt — both a huge part of this San Francisco rotation — are much better when facing righties.
The few notable exceptions for the Giants are Austin Slater, Darin Ruf, and Wilmer Flores, who are a combined 5 for 24 with no homers against Manaea in their careers. If the lefty can navigate his way through those guys, he should help Under bettors quite a bit in this one. Manaea will also need to be careful when pitching to Heliot Ramos. The talented Giants youngster will mostly be playing against lefties this year, and he has a really explosive bat.
As for Webb, this matchup could definitely be a bit better for the righty, who gave up 11 earned runs in 17 innings against this Padres team last season. Webb is, however, one of the more promising young pitchers in the game, and he is as reliable as they come.
The 25-year-old should be even better this season after having a full offseason to work on his game, and he likely thought a lot about how to be better against this specific opponent. This Giants squad generally gets the most out of all its talent, and they’ll have a plan in place to help Webb be more successful.
The Under is 5-2 in San Francisco's last seven games against left-handed starters, which isn't surprising given their struggles against them. Back it again today.
Prediction: Under 7.5 (-122 at UniBet)
Best bet
In addition to liking the Under in the full game, it’s also worth taking a shot on these teams combining to score Under 3.5 runs in the first five innings.
This should be an excellent battle on the hill between two pitchers that are capable of turning in gems. The two of them should go out there and look to outduel one another, meaning this could be even more low-scoring in the early going.
In taking the Under for the first five innings, you don’t have to worry about either bullpen coming in and messing up the work of the starter. Overall, this total might seem low, but it’s not as outrageous as it looks.
Pick: First five innings Under 3.5 (-106 at UniBet)
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