The San Diego Padres visit the heavily favored Chicago Cubs (-150) at Wrigley Field to start a three-game set Monday, June 29.
My top Padres vs. Cubs predictions and MLB picks call for the Chicago lineup to pull away and take the series opener tonight.
Who will win Padres vs Cubs today: Cubs -1.5 (+129)
The wind is forecast to be blistering out at Wrigley Field, and the Chicago Cubs have paced the majors with 6.6 runs per game during their 12-4 heater while also ranking fourth in wOBA and seventh in xwOBA.
So, with the San Diego Padres sending righty Griffin Canning to the bump tonight, I’m anticipating another big night from the Chicago lineup.
Canning has surrendered a 52.1% hard-hit rate, which is tied for the lowest mark in the majors among pitchers with 40 innings.
Of course, the Padres also rank 29th in baseball against left-handed pitchers, so I’m expecting Chicago southpaw Shota Imanaga to hold the San Diego bats in check enough for the Cubs to pull away tonight.
COVERS INTEL: Chicago Cubs lefty Shota Imanaga boasts a high-end 30.3 whiff percentage and 14.5 swinging-striking percentage, which positions him to both keep the San Diego Padres off balance at the plate while paving the way to Chicago covering the run line and keeping the number Under the inflated total.
Padres vs Cubs Over/Under pick: Under 11.5 (-126)
The wind is forecast to be blistering out at Wrigley Field tonight, so we’re receiving an inflated total.
In addition to the noted struggles the Padres have had against lefties this season, they also rank 24th in overall xwOBA while averaging just 3.9 runs per game in June.
Plus, San Diego has played to the Under in 26 of its past 45 road games (+6.20 Units / 13% ROI), and the Padres have only hit the Over in 21 of their last 50 games (-11.10 Units / -20% ROI).
- ML/RL bets: 29-15, +15.57 units
- Over/Under bets: 16-13, +1.97 units
Padres vs Cubs weather
Padres vs Cubs odds
- Moneyline: Padres +130 | Cubs -150
- Run line: Padres +1.5 (-145) | Cubs -1.5 (+125)
- Over/Under: Over 11 (-110) | Under 11(-110)
Padres vs Cubs trend
The San Diego Padres have hit the Under in 26 of their last 45 away games (+6.20 Units / 13% ROI). Find more MLB betting trends for Padres vs. Cubs.
How to watch Padres vs Cubs and game info
| Location | Wrigley Field, Chicago, IL |
| Date | Monday, June 29, 2026 |
| First pitch | 8:05 p.m. ET |
| TV | SDPA, Marquee |
| Padres starting pitcher | Griffin Canning (1-5, 7.38 ERA) |
| Cubs starting pitcher | Shota Imanaga (5-6, 4.40 ERA) |
Padres vs Cubs latest injuries
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